CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery

Comprehensive Interrogation of a Minimalist Synthetic CDR-H3 Library and Its Ability to Generate Antibodies with Therapeutic Potential

(2013) Ciara M. Mahon et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapid optimization and prototyping for therapeutic antibody-like molecules

(2013) Lihui Xu et al.   mAbs

Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL

(2012) M. S. Topp et al.   BLOOD

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

(2011) Amy C. King et al.   PROTEIN SCIENCE

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

(2010) Jennifer S. Michaelson et al.   mAbs

A dual-targeting PDGFRβ/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo

(2010) Robert Mabry et al.   mAbs

Computational analysis of off-rate selection experiments to optimize affinity maturation by directed evolution

(2010) Christian Zahnd et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

(2010) Brian R. Miller et al.   PROTEIN ENGINEERING DESIGN & SELECTION

High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions

(2009) Feng He et al.   ANALYTICAL BIOCHEMISTRY

Treatment of Malignant Pleural Effusion With the Trifunctional Antibody Catumaxomab (Removab) (Anti-EpCAM×Anti-CD3)

(2009) Martin Sebastian et al.   JOURNAL OF IMMUNOTHERAPY

Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

(2009) William J. Finlay et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineering of stable bispecific antibodies targeting IL-17A and IL-23

(2009) Robert Mabry et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A modular IgG-scFv bispecific antibody topology

(2009) Kelly Davis Orcutt et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules

(2009) Jacob L. Jordan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A simple high-throughput purification method for hit identification in protein screening

(2008) Emma Cummins et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody

(2008) R. Bargou et al.   SCIENCE