A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice
出版年份 2014 全文链接
标题
A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice
作者
关键词
-
出版物
JOURNAL OF INFECTIOUS DISEASES
Volume 210, Issue 6, Pages 964-972
出版商
Oxford University Press (OUP)
发表日期
2014-03-29
DOI
10.1093/infdis/jiu196
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Protective Efficacy Induced by Recombinant Clostridium difficile Toxin Fragments
- (2013) Rosanna Leuzzi et al. INFECTION AND IMMUNITY
- A Single VHH-Based Toxin-Neutralizing Agent and an Effector Antibody Protect Mice against Challenge with Shiga Toxins 1 and 2
- (2013) Jacqueline M. Tremblay et al. INFECTION AND IMMUNITY
- Stepwise Engineering of Heterodimeric Single Domain Camelid VHH Antibodies That Passively Protect Mice from Ricin Toxin
- (2013) David J. Vance et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Long-Term Follow-Up of Colonoscopic Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection
- (2012) Lawrence J Brandt et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- MBX-500, a Hybrid Antibiotic withIn VitroandIn VivoEfficacy against Toxigenic Clostridium difficile
- (2012) Michelle M. Butler et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections
- (2012) Jieun Kim et al. BMC INFECTIOUS DISEASES
- A Chimeric Toxin Vaccine Protects against Primary and Recurrent Clostridium difficile Infection
- (2012) Haiying Wang et al. INFECTION AND IMMUNITY
- Protection Against Clostridium difficile Infection With Broadly Neutralizing Antitoxin Monoclonal Antibodies
- (2012) Andre J. Marozsan et al. JOURNAL OF INFECTIOUS DISEASES
- Macro and Micro Diversity of Clostridium difficile Isolates from Diverse Sources and Geographical Locations
- (2012) Richard A. Stabler et al. PLoS One
- A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model
- (2012) Jean Mukherjee et al. PLoS One
- A novel fusion protein containing the receptor binding domains of C. difficile toxin A and toxin B elicits protective immunity against lethal toxin and spore challenge in preclinical efficacy models
- (2012) Jing-Hui Tian et al. VACCINE
- Systematic Review of Intestinal Microbiota Transplantation (Fecal Bacteriotherapy) for Recurrent Clostridium difficile Infection
- (2011) Ethan Gough et al. CLINICAL INFECTIOUS DISEASES
- Immunization with Bacillus Spores Expressing Toxin A Peptide Repeats Protects against Infection with Clostridium difficile Strains Producing Toxins A and B
- (2011) Patima Permpoonpattana et al. INFECTION AND IMMUNITY
- Development and Evaluation of an Ovine Antibody-Based Platform for Treatment of Clostridium difficile Infection
- (2011) April Roberts et al. INFECTION AND IMMUNITY
- Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain
- (2011) Greg Hussack et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Systemic Dissemination of Clostridium difficile Toxins A and B Is Associated With Severe, Fatal Disease in Animal Models
- (2011) Jennifer Steele et al. JOURNAL OF INFECTIOUS DISEASES
- Fidaxomicin versus Vancomycin forClostridium difficileInfection
- (2011) Thomas J. Louie et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Repetitive Oligopeptide Sequences Modulate Cytopathic Potency but Are Not Crucial for Cellular Uptake of Clostridium difficile Toxin A
- (2011) Alexandra Olling et al. PLoS One
- Treatment with Monoclonal Antibodies againstClostridium difficileToxins
- (2010) Israel Lowy et al. NEW ENGLAND JOURNAL OF MEDICINE
- Evolutionary dynamics of Clostridium difficile over short and long time scales
- (2010) M. He et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Camelid single domain antibodies (VHHs) as neuronal cell intrabody binding agents and inhibitors of Clostridium botulinum neurotoxin (BoNT) proteases
- (2010) Jacqueline M. Tremblay et al. TOXICON
- Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile
- (2010) Jordi M. Lanis et al. PLoS Pathogens
- Specific immuno capturing of the Staphylococcal superantigen toxic-shock syndrome toxin-1 in plasma
- (2009) Hendrik Adams et al. BIOTECHNOLOGY AND BIOENGINEERING
- Distinct ribotypes and rates of antimicrobial drug resistance in Clostridium difficile from Shanghai and Stockholm
- (2009) H. Huang et al. CLINICAL MICROBIOLOGY AND INFECTION
- Antibody-Enhanced, Fc Gamma Receptor-Mediated Endocytosis of Clostridium difficile Toxin A
- (2009) X. He et al. INFECTION AND IMMUNITY
- Recurrent Clostridium difficile infection: A review of risk factors, treatments, and outcomes
- (2009) Stuart Johnson JOURNAL OF INFECTION
- Piglet Models of Acute or ChronicClostridium difficileIllness
- (2009) Jennifer Steele et al. JOURNAL OF INFECTIOUS DISEASES
- An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins
- (2009) Xiangyun He et al. JOURNAL OF MICROBIOLOGICAL METHODS
- Single domain antibodies: promising experimental and therapeutic tools in infection and immunity
- (2009) Janusz Wesolowski et al. MEDICAL MICROBIOLOGY AND IMMUNOLOGY
- Clostridium difficile infection: new developments in epidemiology and pathogenesis
- (2009) Maja Rupnik et al. NATURE REVIEWS MICROBIOLOGY
- Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium
- (2009) Richard A Stabler et al. GENOME BIOLOGY
- Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium
- (2008) Guilin Yang et al. BMC MICROBIOLOGY
- General Strategy to Humanize a Camelid Single-domain Antibody and Identification of a Universal Humanized Nanobody Scaffold
- (2008) Cécile Vincke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology
- (2008) B. M. Tijink et al. MOLECULAR CANCER THERAPEUTICS
- Clostridium difficile— More Difficult Than Ever
- (2008) Ciarán P. Kelly et al. NEW ENGLAND JOURNAL OF MEDICINE
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started