A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
出版年份 2011 全文链接
标题
A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
作者
关键词
-
出版物
mAbs
Volume 3, Issue 3, Pages 273-288
出版商
Informa UK Limited
发表日期
2011-07-07
DOI
10.4161/mabs.3.3.15188
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- (2011) Stuart L. Emanuel et al. mAbs
- The insulin-like growth factor-I receptor as an oncogene
- (2011) Haim Werner et al. ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
- CETUXIMAB: From Bench to Bedside
- (2010) B. Vincenzi et al. CURRENT CANCER DRUG TARGETS
- A review of erlotinib – an oral, selective epidermal growth factor receptor tyrosine kinase inhibitor
- (2010) Renuka Iyer et al. EXPERT OPINION ON PHARMACOTHERAPY
- Gefitinib for the treatment of non-small-cell lung cancer
- (2010) Lynn Campbell et al. EXPERT OPINION ON PHARMACOTHERAPY
- The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
- (2010) Markus M. Heiss et al. INTERNATIONAL JOURNAL OF CANCER
- Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity
- (2010) Jianying Dong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Comparative In Vitro Cellular Data Alone Are Insufficient to Predict Clinical Responses and Guide the Choice of BCR-ABL Inhibitor for Treating Imatinib-Resistant Chronic Myeloid Leukemia
- (2010) Pierre Laneuville et al. JOURNAL OF CLINICAL ONCOLOGY
- Gemcitabine Plus Bevacizumab Compared With Gemcitabine Plus Placebo in Patients With Advanced Pancreatic Cancer: Phase III Trial of the Cancer and Leukemia Group B (CALGB 80303)
- (2010) Hedy Lee Kindler et al. JOURNAL OF CLINICAL ONCOLOGY
- Genetic Testing in Li-Fraumeni Syndrome: Uptake and Psychosocial Consequences
- (2010) Chantal R.M. Lammens et al. JOURNAL OF CLINICAL ONCOLOGY
- Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR
- (2010) Jennifer S. Michaelson et al. mAbs
- Bispecific antibodies for cancer therapy
- (2010) Patrick Chames et al. mAbs
- Stability engineering of scFvs for the development of bispecific and multivalent antibodies
- (2010) Brian R. Miller et al. PROTEIN ENGINEERING DESIGN & SELECTION
- High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients
- (2009) V. Ludovini et al. ANNALS OF ONCOLOGY
- Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma
- (2009) C. Desbois-Mouthon et al. CLINICAL CANCER RESEARCH
- Integration of panitumumab into the treatment of colorectal cancer
- (2009) Cristina Gravalos et al. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
- Crosstalk Between Epidermal Growth Factor Receptor- and Insulin-Like Growth Factor-1 Receptor Signaling: Implications for Cancer Therapy
- (2009) J. Veeken et al. CURRENT CANCER DRUG TARGETS
- ErbB receptors and signaling pathways in cancer
- (2009) Nancy E Hynes et al. CURRENT OPINION IN CELL BIOLOGY
- Bispecific antibodies for cancer therapy
- (2009) Nurit Hollander Immunotherapy
- Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties
- (2009) Adam Doern et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Population Pharmacokinetic Analysis of Panitumumab in Patients With Advanced Solid Tumors
- (2009) Peiming Ma et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis
- (2009) S. Kaulfuss et al. MOLECULAR CANCER THERAPEUTICS
- Emerging role of insulin-like growth factor receptor inhibitors in oncology: early clinical trial results and future directions
- (2009) A Gualberto et al. ONCOGENE
- Feedback Mechanisms Promote Cooperativity for Small Molecule Inhibitors of Epidermal and Insulin-Like Growth Factor Receptors
- (2008) E. Buck et al. CANCER RESEARCH
- Autocrine Production of Amphiregulin Predicts Sensitivity to Both Gefitinib and Cetuximab in EGFR Wild-type Cancers
- (2008) K. Yonesaka et al. CLINICAL CANCER RESEARCH
- Association of K-ras Mutational Status and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Receiving Panitumumab Alone
- (2008) Daniel J. Freeman et al. Clinical Colorectal Cancer
- KRASMutations As an Independent Prognostic Factor in Patients With Advanced Colorectal Cancer Treated With Cetuximab
- (2008) Astrid Lièvre et al. JOURNAL OF CLINICAL ONCOLOGY
- Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials
- (2008) J. Rodon et al. MOLECULAR CANCER THERAPEUTICS
- HER receptor signaling confers resistance to the insulin-like growth factor-I receptor inhibitor, BMS-536924
- (2008) P. Haluska et al. MOLECULAR CANCER THERAPEUTICS
- Relationships of Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor Expression to Clinical Outcomes in Patients with Colorectal Cancer
- (2008) Daisuke Takahari et al. ONCOLOGY
- EGFR-targeted therapies in lung cancer: predictors of response and toxicity
- (2008) Rebecca Suk Heist et al. PHARMACOGENOMICS
- Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody
- (2008) R. Bargou et al. SCIENCE
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