Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent

Abstract 2774: Complete results from a phase Ia dose-escalation and dose-expansion study of single-agent MetMAb, a monovalent antagonist antibody to the receptor MET, administered intravenously in patients with locally advanced or metastatic solid tumors

(2011) Ravi Salgia et al.   CANCER RESEARCH

Structural insights into Met receptor activation

(2011) Hartmut H. Niemann   EUROPEAN JOURNAL OF CELL BIOLOGY

Effective Use of Thalidomide in the Treatment of Recurrent Metastatic Chordoma

(2011) Wen Yee Chay et al.   JOURNAL OF CLINICAL ONCOLOGY

Validation of a New Risk Assessment Model for Predicting Adverse Events in Children With Fever and Chemotherapy-Induced Neutropenia

(2011) Karin G.E. Miedema et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutic assessment of SEED: a new engineered antibody platform designed to generate mono- and bispecific antibodies

(2011) M. Muda et al.   PROTEIN ENGINEERING DESIGN & SELECTION

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overexpression of TrkB promotes the progression of colon cancer

(2010) YINGJIAO YU et al.   APMIS

Monovalency Unleashes the Full Therapeutic Potential of the DN-30 Anti-Met Antibody

(2010) Giovanni Pacchiana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhancing Antibody Fc Heterodimer Formation through Electrostatic Steering Effects

(2010) Kannan Gunasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development trends for human monoclonal antibody therapeutics

(2010) Aaron L. Nelson et al.   NATURE REVIEWS DRUG DISCOVERY

High-grade glioma mouse models and their applicability for preclinical testing

(2009) Nienke A. de Vries et al.   CANCER TREATMENT REVIEWS

Aglycosylated IgG variants expressed in bacteria that selectively bind Fc RI potentiate tumor cell killing by monocyte-dendritic cells

(2009) S. T. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival

(2008) H. Jin et al.   CANCER RESEARCH

Neonatal Fc Receptor Mediates Internalization of Fc in Transfected Human Endothelial Cells

(2008) Nancy A. Goebl et al.   MOLECULAR BIOLOGY OF THE CELL