Toxicology-based cancer causation analysis of CoCr-containing hip implants: a quantitative assessment of genotoxicity and tumorigenicity studies

Metal-on-metal Bearing Surfaces

(2016) Joshua J. Jacobs et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Cancer incidence and cause-specific mortality in patients with metal-on-metal hip replacements in Finland

(2014) Keijo T Mäkelä et al.   Acta Orthopaedica

Correlation of blood Cr(III) and adverse health effects: Application of PBPK modeling to determine non-toxic blood concentrations

(2014) Andrew D. Monnot et al.   CRITICAL REVIEWS IN TOXICOLOGY

Quantification of metal ion induced DNA damage with single cell array based assay

(2013) Yong Qiao et al.   ANALYST

Consequences of exposure to peri-articular injections of micro- and nano-particulate cobalt–chromium alloy

(2013) Christopher Brown et al.   BIOMATERIALS

Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity

(2013) Vijay Krishna Raghunathan et al.   BIOMATERIALS

Physiologically based pharmacokinetic model for humans orally exposed to chromium

(2013) C.R. Kirman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Interpreting cobalt blood concentrations in hip implant patients

(2013) Dennis J. Paustenbach et al.   CLINICAL TOXICOLOGY

Hip replacement: Landmark surgery in modern medical history

(2013) Stephen J. Mellon et al.   MATURITAS

Patterns of Risk of Cancer in Patients with Metal-on-Metal Hip Replacements versus Other Bearing Surface Types: A Record Linkage Study between a Prospective Joint Registry and General Practice Electronic Health Records in England

(2013) Arief Lalmohamed et al.   PLoS One

Tea and human health: The dark shadows

(2013) Aditi Jain et al.   TOXICOLOGY LETTERS

Induction of Micronuclei in Mice Bone Marrow Cells by Cobalt and Copper Chlorides

(2013) Pinar Goc Rasgele et al.   Archives of Environmental Protection

Fatal cardiomyopathy after revision total hip replacement for fracture of a ceramic liner

(2013) M. G. Zywiel et al.   Bone & Joint Journal

A prospective study of a ceramic-on-metal bearing in total hip arthroplasty

(2013) H. A. Kazi et al.   Bone & Joint Journal

Blood metal ion testing is an effective screening tool to identify poorly performing metal-on-metal bearing surfaces

(2013) R. P. Sidaginamale et al.   Bone & Joint Research

Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation

(2012) Haiyuan Zhang et al.   ACS Nano

Inorganic cobalt supplementation: Prediction of cobalt levels in whole blood and urine using a biokinetic model

(2012) Kenneth M. Unice et al.   FOOD AND CHEMICAL TOXICOLOGY

Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli

(2012) Celina Janion   International Journal of Biological Sciences

Local and systemic toxicity of nanoscale debris particles in total hip arthroplasty

(2012) Ioannis Polyzois et al.   JOURNAL OF APPLIED TOXICOLOGY

Distribution of metal released from cobalt-chromium alloy orthopaedic wear particles implanted into air pouches in mice

(2012) Grace A. Afolaranmi et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Dose-Response Relationships For Blood Cobalt Concentrations and Health Effects: A Review of the Literature and Application of a Biokinetic Model

(2012) Brent L. Finley et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Measurement of Single Cell Refractive Index, Dry Mass, Volume, and Density Using a Transillumination Microscope

(2012) Kevin G. Phillips et al.   PHYSICAL REVIEW LETTERS

Molecular and immune toxicity of CoCr nanoparticles in MoM hip arthroplasty

(2012) Harinderjit S. Gill et al.   TRENDS IN MOLECULAR MEDICINE

Risk of cancer with metal-on-metal hip replacements: population based study

(2012) K. T. Makela et al.   BMJ-British Medical Journal

Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statistics

(2012) A. J. Smith et al.   BMJ-British Medical Journal

Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells

(2011) Masanori Horie et al.   ENVIRONMENTAL TOXICOLOGY

Malignant Fibrous Histiocytoma at the Site of an Alumina-on-Alumina-Bearing Total Hip Arthroplasty Mimicking Infected Trochanteric Bursitis

(2011) Pil Whan Yoon et al.   JOURNAL OF ARTHROPLASTY

Chromium-Induced Genotoxicity and Interference in Human Lymphoblastoid Cell (TK6) Repair Processes

(2011) Naouale El-Yamani et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Volumetric wear assessment of failed metal-on-metal hip resurfacing prostheses

(2011) J.K. Lord et al.   WEAR

Hierarchies in eukaryotic genome organization: Insights from polymer theory and simulations

(2011) Balaji VS Iyer et al.   BMC Biophysics

The chemical form of metallic debris in tissues surrounding metal-on-metal hips with unexplained failure

(2010) Alister J. Hart et al.   Acta Biomaterialia

Thresholds for indirect DNA damage across cellular barriers for orthopaedic biomaterials

(2010) Michael C. Parry et al.   BIOMATERIALS

A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up

(2010) Tuomo Visuri et al.   BMC MUSCULOSKELETAL DISORDERS

Survival of Hard-on-Hard Bearings in Total Hip Arthroplasty: A Systematic Review

(2010) Michael G. Zywiel et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Polyneuropathy caused by cobalt-chromium metallosis after total hip replacement

(2010) Tokuhei Ikeda et al.   MUSCLE & NERVE

The genotoxicity of physiological concentrations of chromium (Cr(III) and Cr(VI)) and cobalt (Co(II)): An in vitro study

(2010) Martin Figgitt et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

The in vitro genotoxicity of orthopaedic ceramic (Al2O3) and metal (CoCr alloy) particles

(2010) Aikaterini Tsaousi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Bacterial Chromosome Organization and Segregation

(2010) E. Toro et al.   Cold Spring Harbor Perspectives in Biology

Dose-dependent cytotoxicity of clinically relevant cobalt nanoparticles and ions on macrophagesin vitro

(2009) Young-Min Kwon et al.   Biomedical Materials

Genotoxicity assessment of chromium(III) propionate complex in the rat model using the comet assay

(2009) Halina Staniek et al.   FOOD AND CHEMICAL TOXICOLOGY

Nanoparticles can cause DNA damage across a cellular barrier

(2009) Gevdeep Bhabra et al.   Nature Nanotechnology

Introducing a true internal standard for the Comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair

(2009) M. Zainol et al.   NUCLEIC ACIDS RESEARCH

Effects of chromium picolinate on glycemic control and kidney of the obese Zucker rat

(2009) Mahmood S Mozaffari et al.   Nutrition & Metabolism

Presence of corrosion products and hypersensitivity-associated reactions in periprosthetic tissue after aseptic loosening of total hip replacements with metal bearing surfaces

(2008) M HUBER et al.   Acta Biomaterialia

Study of Oxidative Damage in Growing–Finishing Pigs with Continuous Excess Dietary Chromium Picolinate Intake

(2008) Gao-Yi Tan et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

2008 John Charnley Award: Metal Ion Levels After Metal-on-Metal Total Hip Arthroplasty: A Randomized Trial

(2008) C. Anderson Engh et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

In Vivo Wear Rate of the Birmingham Hip Resurfacing Arthroplasty

(2008) Wolf-Christoph Witzleb et al.   JOURNAL OF ARTHROPLASTY

Severe Cobalt Intoxication Due to Prosthesis Wear in Repeated Total Hip Arthroplasty

(2008) Marcus Oldenburg et al.   JOURNAL OF ARTHROPLASTY

Chromosomal Aberrations in the Peripheral Blood of Patients with Metal-on-Metal Hip Bearings

(2008) E Dunstan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Metal Ion Levels in the Blood of Patients After Hip Resurfacing: A Comparison Between Twenty-eight and Thirty-six-Millimeter-Head Metal-on-Metal Prostheses

(2008) John Antoniou et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Modes of Implant Failure After Hip Resurfacing: Morphological and Wear Analysis of 267 Retrieval Specimens

(2008) Michael M Morlock et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Comparing metabolic effects of six different commercial trivalent chromium compounds

(2008) Harry G. Preuss et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro

(2008) R. Colognato et al.   MUTAGENESIS

Macrophages detoxify the genotoxic and cytotoxic effects of surgical cobalt chrome alloy particles but not quartz particles on human cells in vitro

(2008) I. Papageorgiou et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Analysis of metal ion-induced DNA damage, apoptosis, and necrosis in human (Jurkat) T-cells demonstrates Ni2+and V3+are more toxic than other metals: Al3+, Be2+, Co2+, Cr3+, Cu2+, Fe3+, Mo5+, Nb5+, Zr2+

(2007) Marco Caicedo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A