Article
Materials Science, Multidisciplinary
Sushil Kumar, Savita Chaudhary, Ganga Ram Chaudhary
Summary: The study focused on investigating the potential aptitude of rare-earth-doped Gadolinium oxide (Gd2O3) nanoparticles with biological entities in aqueous media. By synthesizing a series of Pr@Gd2O3 NPs with different dopant concentrations, the optical, magnetic and thermal properties were analyzed, along with assessing the biocompatibility through in vitro studies. The results demonstrated that Pr@Gd2O3 NPs showed high biocompatibility under various concentrations of Pr doping.
MATERIALS CHEMISTRY AND PHYSICS
(2022)
Article
Obstetrics & Gynecology
Seo-Jin Park, Ji-You Min, Jeom-Soon Kang, Byung-Guk Yang, Seung-Yong Hwang, Sung-Hee Han
Summary: This study investigated the demographic data and karyotypes of 19,000 couples who experienced recurrent spontaneous abortion (RSA). The results showed that 4.44% of the couples had chromosomal aberrations, with females being more likely to have them. The mean age of individuals with chromosomal aberrations was younger, and there were significant correlations between sex and age distribution and the subtypes of chromosomal aberrations.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Zhigang Liu, Qiang Zeng, Bing Xiang
Summary: Bortezomib-based regimens can overcome the poor prognosis derived from del(13q14), amp(1q21), t(4,14), t(14,16) but not del(17q13) in patients with multiple myeloma.
Article
Orthopedics
Dongmei Wu, Rohan M. Bhalekar, Jordan S. Marsh, David J. Langton, Alan J. Stewart
Summary: Implants made of cobalt-chromium alloy in joint replacement surgeries can lead to a complication called ALVAL, characterized by metal debris and metal ions causing hypersensitivity response. Current diagnostic tests and guidelines for ALVAL are not standardized.
EFORT OPEN REVIEWS
(2022)
Article
Hematology
Moritz Fuerstenau, Yvonne J. Thus, Sandra Robrecht, Clemens H. M. Mellink, Anne-Marie van der Kevie-Kersemaekers, Julie Dubois, Julia von Tresckow, Michaela Patz, Michael Gregor, Patrick Thornton, Philipp B. Staber, Tamar Tadmor, Mark-David Levin, Caspar da Cunha-Bang, Christof Schneider, Christian Bjoern Poulsen, Thomas Illmer, Bjoern Schoettker, Ann Janssens, Ilse Christiansen, Thomas Noesslinger, Michael Baumann, Holger Hebart, Tobias Gaska, Josien C. Regelink, Ellen C. Dompeling, Vesa Lindstroem, Gunnar Juliusson, Anouk Widmer, Jeroen Goede, Neta Goldschmidt, Florian Simon, Nisha De Silva, Anna-Maria Fink, Kirsten Fischer, Clemens-Martin Wendtner, Matthias Ritgen, Monika Brueggemann, Eugen Tausch, Marcel Spaargaren, Eric Eldering, Stephan Stilgenbauer, Carsten U. Niemann, Michael Hallek, Barbara Eichhorst, Karl-Anton Kreuzer, Arnon P. Kater
Summary: The impact of karyotype complexity on the treatment outcomes of chronic lymphocytic leukemia (CLL) patients was evaluated in this study. It was found that complex karyotypes were associated with inferior outcomes in patients treated with chemoimmunotherapy (CIT), while highly complex karyotypes and translocations were identified as adverse prognostic factors in patients undergoing venetoclax-based treatments. The findings suggest that karyotyping should be incorporated into the standard diagnostic workup of CLL to improve prognostication.
Article
Obstetrics & Gynecology
Radhia M'kacher, Bruno Colicchio, Valentine Marquet, Claire Borie, Wala Najar, William M. Hempel, Leonhard Heidingsfelder, Noufissa Oudrhiri, Mustafa Al Jawhari, Nadege Wilhelm-Murer, Marguerite Miguet, Alain Dieterlen, Georges Deschenes, Anne-Claude Tabet, Steffen Junker, Michael Grynberg, Michael Fenech, Annelise Bennaceur-Griscelli, Philippe Voisin, Patrice Carde, Eric Jeandidier, Catherine Yardin
Summary: The study found that telomere length of patients with infertility was significantly shorter than healthy donors, and patients with infertility showed more pronounced telomere shortening and abnormalities, especially in patients with structural chromosomal aberrations.
FERTILITY AND STERILITY
(2021)
Article
Engineering, Mechanical
Andrew R. Beadling, Michael G. Bryant, Duncan Dowson, Anne Neville
Summary: The study investigates the failure mechanisms of metal-on-metal total hip replacements, with focus on the effects of acetabular inclination and retroversion on corrosive material loss. It suggests that current ISO standards may not accurately represent degradation mechanisms in devices with metal sliding interfaces.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART J-JOURNAL OF ENGINEERING TRIBOLOGY
(2021)
Article
Genetics & Heredity
Szilvia Ando, Katalin Koczok, Beata Bessenyei, Istvan Balogh, Aniko Ujfalusi
Summary: Chromosome abnormalities are crucial in reproductive failure. A study in infertile patients found higher rates of structural aberrations compared to a control group, suggesting a potential causal relationship between these abnormalities and infertility.
Article
Engineering, Environmental
Sakthi Thesai Annadurai, Chinnasamy Ragavendran, Chinnaperumal Kamaraj, Rajakumar Sundaram, Mohankumar Periyasamy, Manikandan Rajendran, Ayyasamy Pudukadu Munusamy, Leticia Paiva Matos, Guilherme Malafaia
Summary: The present study focuses on the use of dead fungal mycelium as novel adsorbents for defluorination, and the results showed that the isolated fungus Aspergillus niger exhibited high fluoride adsorption capacity. The biosorption behavior followed pseudo-second-order kinetics and the Langmuir isotherm. Additionally, the study also found genotoxic effects of fluoride water contamination on biota through chromosome analysis. Therefore, the research has both theoretical and practical significance in the management of environmental pollution.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Medicine, Research & Experimental
Onat Kadioglu, Mohamed E. M. Saeed, Nuha Mahmoud, Shaymaa Azawi, Kristin Mrasek, Thomas Liehr, Thomas Efferth
Summary: The study characterized U87.MG Delta EGFR glioblastoma cells with constitutively active EGFR and identified novel drug resistance mechanisms related to the expression of mutation-activated EGFR. The cells showed numerous chromosomal aberrations and gene overexpression, including well-known drug resistance genes and novel ones. These findings may have important implications for future treatment strategies.
Article
Obstetrics & Gynecology
Lena Sagi-Dain, Amihood Singer, Reeval Segel, Racheli Berger, Bibi Kanengisser-Pines, Idit Maya
Summary: The study found that the residual risk of clinically significant chromosomal microarray analysis results in pregnancies with fetuses with congenital heart defects following normal noninvasive prenatal screening was higher than those in pregnancies with normal ultrasound. The detection rate of noninvasive prenatal screening varied depending on the type of congenital heart defect, with higher risks in certain subtypes. It is important for obstetricians and genetic counselors to consider this information when deciding on diagnostic testing options.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jovana Tubic Vukajlovic, Ivan Simic, Olivera Milosevic-djordjevic
Summary: The study aimed to assess DNA and chromosomal damage in ACS patients' PBLs and examine the impact of coronary angiographies. Results showed higher levels of DNA and chromosomal damage in ACS patients compared to controls, with significantly increased damage post-CAG. AMI patients exhibited more severe damage than UAP patients, especially post-CAG.
ANATOLIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Biology
Laura E. Ewing, Rupak Pathak, Reid D. Landes, Charles M. Skinner, Regina Binz, Sean G. Young, Sheldon Riklon, Shelbie Stahr, Joseph Su, Marjan Boerma, Pearl A. McElfish, Martin Hauer-Jensen, Igor Koturbash
Summary: The purpose of this study was to investigate the genetic and epigenetic effects of exposure to ionizing radiation in the Marshallese population, with a focus on Northwest Arkansas, and to analyze its role in health disparities experienced by this Pacific Island nation.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Environmental Sciences
M. Alaguprathana, M. Poonkothai, Mysoon M. Al-Ansari, Latifah Al-Humaid, Woong Kim
Summary: This study assessed the cytogenotoxic effect of untreated and methyl orange treated on Allium cepa roots. It was found that roots exposed to treated dye solution had higher root growth, root length, and mitotic index, while roots exposed to untreated dye solution showed higher mitotic inhibition and chromosomal abnormalities. The research can be used as a biomarker to detect the genotoxic effects of textile dyes on biota.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Mette Holm Hjorth, Inger Mechlenburg, Frederik Nicolai Foldager, Marianne Tjur, Maiken Stilling
Summary: The study compared muscle mass, power, step test asymmetry, and patient-reported outcomes between MoM THA/HRA and MoP THA, finding no significant differences in functional outcomes.
APPLIED SCIENCES-BASEL
(2022)