Article
Endocrinology & Metabolism
Qinghe Meng, Derek M. Culnan, Tamer Ahmed, Mingjie Sun, Robert N. Cooney
Summary: Roux-en-Y gastric bypass (RYGB) has significant effects on intestinal GLP-1 release and glucose transport in obese rats, potentially improving glycemic control by increasing GRP119 and FFAR2/3.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Chemical
Xiande Xie, Jingxia Li, Jing Liu, Zhuo Chen, Xiaoqing Yuan, Tao Chen, Lin Luo
Summary: Chromium picolinate (Cr(pic)3), widely used in animal feeding, can be introduced to the environment through animal waste, leading to chromium contamination risk. Direct adsorption and precipitation methods for removing chromium in Cr(pic)3 form are difficult. This study investigated the treatment of Cr(pic)3 using the Fenton process and found that it can effectively degrade Cr(pic)3 and remove chromium simultaneously, making it promising for treating Cr(pic)3-containing wastewater.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ruben Moreira, Ana D. Martins, Marco G. Alves, Maria de Lourdes Pereira, Pedro F. Oliveira
Summary: Low testosterone levels are a major cause of male infertility, and endocrine-disrupting chemicals such as chromium (Cr) can affect testicular steroidogenesis and male fertility. In particular, Cr(III) picolinate (CrPic(3)) has been found to inhibit enzymes involved in steroidogenesis and impact reactive oxygen species (ROS) levels, testosterone levels, and sperm motility and count. However, further research is needed to fully understand the effects of CrPic(3) on male fertility and ensure its safety for use by men.
Article
Agriculture, Dairy & Animal Science
Guangju Wang, Xiumei Li, Ying Zhou, Jinghai Feng, Minhong Zhang
Summary: High ambient temperature negatively affects the growth and gut microbiota, gastrointestinal peptides, and glucose homeostasis in broilers. This research found that supplementation of 0.4 mg/kg chromium can improve the growth performance, insulin resistance, and sodium-glucose transporter 1 expression in broilers, as well as alter the gut microbiota structure and secretion of gastrointestinal peptides.
Article
Chemistry, Medicinal
Samira Aouichat, Miguel Navarro-Alarcon, Pablo Alarcon-Guijo, Diego Salagre, Marwa Ncir, Lazhar Zourgui, Ahmad Agil
Summary: The study demonstrated that melatonin can play a renoprotective role by suppressing ER stress and the pro-apoptotic IRE1α/JNK signaling pathway.
Article
Microbiology
Michael S. Robeson, Kanishka Manna, Christopher Randolph, Stephanie Byrum, Reza Hakkak
Summary: Obesity is the leading cause of health-related diseases globally. This study investigated the effects of short-term metformin treatment on the gut microbiota profile in an obese rat model. The results showed that short-term metformin treatment altered the composition of the gut microbiota, particularly the Bacteroides species, in obese rats.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Analytical
Missael Antonio Arroyo Negrete, Kazimierz Wrobel, Eunice Yanez Barrientos, Alma Rosa Corrales Escobosa, Israel Enciso Donis, Katarzyna Wrobel
Summary: In this study, flow injection analysis (FIA) was used as a sample introduction method for an electrospray ionization - ion trap mass spectrometer (ESI-ITMS) to quantify CrPic(3) in commercial supplements. The FIA system operated with ammonium formate as a carrier solution, and cobalt picolinate was used as an internal standard (IS). The results showed that the proposed FIA-ESI-ITMS/MS procedure is a suitable method for the determination of CrPic(3) in such products.
Article
Biochemistry & Molecular Biology
Lionel Carneiro, Claire Fenech, Fabienne Lienard, Sylvie Grall, Besma Abed, Joulia Haydar, Camille Allard, Lucie Desmoulins, Romain Paccoud, Marie-Claude Brindisi, Thomas Mouillot, Laurent Brondel, Xavier Fioramonti, Luc Penicaud, Agnes Jacquin-Piques, Corinne Leloup
Summary: This study found that obese and insulin-resistant rats lacking ghrelin exhibited hypersensitivity to glucose and excessive insulin secretion, which could be reversed by ghrelin treatment. These findings suggest that ghrelin modulates glucose hypersensitivity and insulin secretion through regulating mitochondrial metabolism and reactive oxygen species signaling.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Nutrition & Dietetics
Aslaug Drotningsvik, Age Oterhals, Svein Are Mjos, Linn Anja Vikoren, Ola Flesland, Oddrun Anita Gudbrandsen
Summary: The study found that diets containing blue whiting protein can attenuate the increase in blood pressure in obese rats prone to hypertension and renal failure, possibly mediated through the renin-angiotensin system, without affecting markers of kidney function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Ahmed Sultan, Muhammad Anwar Qureshi, Frank Christopher Howarth
Summary: Obesity is a major risk factor for diabetes, which can lead to cardiovascular complications including electromechanical dysfunction in the heart. This study found that the effects of Isoprenaline, a medication used to treat certain heart conditions, on ventricular myocyte shortening were diminished in obese and diabetic obese rats compared to lean rats. These findings suggest that abnormalities in Ca2+ signaling and SR Ca2+ transport may contribute to the decreased effectiveness of Isoprenaline in obesity and diabesity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stepan Melnyk, Reza Hakkak
Summary: Excessive weight and obesity are major risk factors for chronic diseases, including diabetes. Metformin, a medication commonly used for diabetes, has been found to significantly improve complications associated with the disease. In this study, metabolomics was used to analyze the effects of metformin on lean and obese Zucker rats, revealing both positive and negative impacts on different rat groups.
Article
Agriculture, Dairy & Animal Science
Alex T. Hung, Brian J. Leury, Matthew A. Sabin, Fahri Fahri, Kristy DiGiacomo, Tu-Fa Lien, Frank R. Dunshea
Summary: Two studies evaluated the effect of nano chromium picolinate (nCrPic) on sheep during heat stress. The results showed that dietary nCrPic can increase feed intake and weight gain, as well as alleviate the negative effects of heat stress on sheep.
Article
Urology & Nephrology
Sjoukje van der Hoek, Niels Jongs, Megumi Oshima, Brendon L. L. Neuen, Jasper Stevens, Vlado Perkovic, Adeera Levin, Kenneth W. W. Mahaffey, Carol Pollock, Tom Greene, David C. C. Wheeler, Meg J. J. Jardine, Hiddo J. L. Heerspink
Summary: In the CREDENCE trial, canagliflozin was found to have a greater impact on eGFR slope in patients with higher baseline HbA1c levels, indicating that patients with poorer glycemic control may benefit more from the drug.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Pediatrics
Chonnikant Visuthranukul, Cameron Hurst, Sirinuch Chomtho
Summary: The low-glycemic index diet did not have a significant effect on plasma adipokines, but higher baseline leptin levels were associated with lower reductions in fat mass. Leptin resistance may hinder the reduction of adiposity in obese children, and baseline leptin could serve as a useful predictor for changes in body composition during obesity intervention.
PEDIATRIC RESEARCH
(2021)
Article
Medicine, General & Internal
Stinne Byrholdt Sogaard, Sofie Bech Andersen, Iman Taghavi, Carlos Armando Villagomez Hoyos, Christina Christoffersen, Kristoffer Lindskov Hansen, Jorgen Arendt Jensen, Michael Bachmann Nielsen, Charlotte Mehlin Sorensen
Summary: This study utilized super-resolution ultrasound imaging to quantify renal vascular density and tortuosity in obese rats. The results showed increased vascular density in obese rats and a decrease in glomerular filtration rate and increase in albumin/creatinine ratio. Further research is needed to confirm these findings.
Retraction
Biochemistry & Molecular Biology
A. B. El-Remessy, M. Al-Shabrawey, D. H. Platt, M. Bartoli, M. A. Behzadian, N. Ghaly, N. Tsai, K. Motamed, R. B. Caldwell
Article
Cell Biology
Islam N. Mohamed, Nahla Reda Sarhan, Mohamed Ahmed Eladl, Azza B. El-Remessy, Mohamed El-Sherbiny
Article
Biochemistry & Molecular Biology
Riyaz Mohamed, Maha Concha, Sally L. Elshaer, Sandeep Artham, Tahira Lemtalsi, Azza B. El-Remessy
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Correction
Multidisciplinary Sciences
Azza B. El-Remessy, Telina Franklin, Nagla Ghaley, Jinling Yang, Michael W. Brands, Ruth B. Caldwell, Mohamed Ali Behzadian
Article
Multidisciplinary Sciences
Sally L. Elshaer, Azza B. El-Remessy
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Sally L. Elshaer, Abdulrahman Alwhaibi, Riyaz Mohamed, Tahira Lemtalsi, Maha Coucha, Frank M. Longo, Azza B. El-Remessy
Article
Biochemistry & Molecular Biology
Maha Coucha, Ahmed Y. Shanab, Mohamed Sayed, Almira Vazdarjanova, Azza B. El-Remessy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Islam N. Mohamed, Nader Sheibani, Azza B. El-Remessy
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Sally L. Elshaer, Hang-soo Park, Laura Pearson, William D. Hill, Frank M. Longo, Azza B. El-Remessy
Summary: The study found that modulating the neurotrophin receptor p75(NTR) can enhance the vascular protection of MSCs in an acute model of retinal ischemia/reperfusion, reducing the formation of acellular capillaries and promoting angiogenic response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Sally L. Elshaer, Salma H. Bahram, Pranav Rajashekar, Rajashekhar Gangaraju, Azza B. El-Remessy
Summary: Mesenchymal stem cells (MSCs) have regenerative effects primarily through paracrine effects mediated by the secretion of bioactive molecules. However, the restoration of MSCs' functional capabilities and the utilization of secretome therapies face challenges such as the heterogeneity of MSCs and the complexity of the secretome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Meeting Abstract
Ophthalmology
Azza B. El-Remessy, Sally L. Elshaer
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Meeting Abstract
Ophthalmology
Sally L. Elshaer, William Dave Hill, Rajashekhar Gangaraju, Azza B. El-Remessy
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2017)
Review
Ophthalmology
Sally L. Elshaer, Azza B. El-Remessy
EXPERT REVIEW OF OPHTHALMOLOGY
(2017)
Article
Endocrinology & Metabolism
Maha Coucha, Islam N. Mohamed, Sally L. Elshaer, Osinakachuk Mbata, Megan L. Bartasis, Azza B. El-Remessy
WORLD JOURNAL OF DIABETES
(2017)
Article
Biochemistry & Molecular Biology
Sally L. Elshaer, Tahira Lemtalsi, Azza B. El-Remessy