期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 126, 期 1-3, 页码 129-140出版社
HUMANA PRESS INC
DOI: 10.1007/s12011-008-8207-7
关键词
Chromium picolinate; Pig; Excess; Oxidative damage
资金
- National Natural Science Foundation of People's Republic of China [30571350]
- The Eleventh 5-Year National Key Technology R&D Program of China [2006BAD14B02-8]
Chromium picolinate (CrPic) is a popular nutritional supplement; however, its safety has been questioned as it may be a source of oxidative stress that induces genotoxicity. The current work investigated the effect of excessive CrPic intake on oxidative damage in growing-finishing pigs. Thirty castrated male pigs, weighing approximately 30 kg each, were randomly divided into five groups and fed a diet with 0, 200, 800, 1,600, 3,200 mu g of Cr/kg feed as CrPic for 80 days (approximately the entire growing-finishing period). High CrPic dose significantly decreased superoxide dismutase activity in serum at 80 days as well as the catalase activity in kidney (p < 0.05); however, compared to controls, malondialdehyde in tissue and serum, urinary 8-hydroxydeoxyguanosine level, and DNA strand breaks in liver and kidney had no notable differences (p > 0.05). These results suggested that long-term exposure to different doses of CrPic in feed did not increase the formation of biomarkers of oxidative damage in growing-finishing pigs. However, taking into account the changes of antioxidant enzymes activity, excessive dietary CrPic intake was not recommended in this study.
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