Article
Environmental Sciences
Sardar Khan, Zahir Qamar, Ajmal Khan, Muhammad Waqas, Javed Nawab, Muhmmmad Khisroon, Ajmal Khan
Summary: This study investigated the genotoxic effects of polycyclic aromatic hydrocarbons (PAHs) present in vehicle-wash wastewater (VWW) on fish and freshwater mussels. The results showed that the genotoxicity of VWW on both fish and mussels increased with the duration of exposure, indicating the high genotoxicity of VWW and the need for treatment before discharge into aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Felipe de Araujo Nascimento, Daniela de Melo e Silva, Thays Millena Alves Pedroso, Jheneffer Sonara Aguiar Ramos, Michelle Rocha Parise
Summary: Occupational exposure to pesticides in farmers results in significant DNA damage, showing a notable impact and variability in the studies. Smokers who are occupationally exposed to pesticides have slightly reduced DNA damage compared to non-smokers, indicating some genetic toxicity. The study demonstrates a higher risk of occupationally exposed rural workers developing related diseases due to the genotoxic effect of pesticides.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Sergey Petrovich Kukla, Victor Pavlovich Chelomin, Andrey Alexandrovich Mazur, Valentina Vladimirovna Slobodskova
Summary: This study compared the effects of zinc ions and zinc oxide nanoparticles on the sperm of marine organisms. The results showed that both pollutants caused an increase in DNA damage, and the increase in DNA damage varied with the concentration of pollutants in different experimental groups.
Article
Pharmacology & Pharmacy
Giselle S. Meireles, Rafaela Aires, Larissa Z. Coco, Edgar H. Kampke, Maria E. S. Barroso, Elisardo C. Vasquez, Thiago M. C. Pereira, Silvana S. Meyrelles, Bianca P. Campagnaro
Summary: This study found that renovascular hypertension can cause oxidative damage and impaired DNA repair in bone marrow cells, leading to compromised hematopoiesis. It provides new insights into the influence of hypertension on bone marrow homeostasis.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Chemistry, Medicinal
Zeineb Marzougui, Sylvie Huet, Anne-Louise Blier, Ludovic Le Hegarat, Haifa Tounsi-Kettiti, Riadh Kharrat, Riadh Marrouchi, Valerie Fessard
Summary: In this study, the in vivo genotoxic effects of C17-sphinganine analog mycotoxin (C17-SAMT) were evaluated using comet assays and micronucleus assay. The results showed that C17-SAMT induced DNA damage in the duodenum and spleen, but had no significant effect on chromosome and genome damage in the bone marrow. Microscopic observations of the liver revealed increased mitosis and hepatocytes' cytoplasm clarification.
Article
Environmental Sciences
Claudia Castro, Ana Carvalho, Isabel Gaivao, Jose Lima-Brito
Summary: The study evaluated the tolerance of four wine-producing varieties to different concentrations of Cu by treating V. vinifera cuttings with Cu-rich hydroponic solutions. It was found that 50μM Cu treatment increased DNA damage, with 'Tinto Cao' being the most sensitive variety. Comet-FISH analysis revealed partial damage on rDNA and telomeric DNA in response to Cu treatment.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Cell Biology
Nasrin Ghassemi-Barghi, Zeynab Ehsanfar, Omid Mohammadrezakhani, Sorour Ashari, Shamim Ghiabi, Zahra Bayrami
Summary: ARA290 has been found to exert a protective effect against cisplatin-induced nephrotoxicity by anti-apoptotic, anti-inflammatory, and antioxidant mechanisms, suggesting its potential as a new therapeutic approach for acute kidney injury patients.
Article
Environmental Sciences
Ronan Adler Tavella, Caroline Lopes Feijo Fernandes, Lucia Emanueli Schimith, Lisiane Martins Volcao, Marina dos Santos, Flavio Manoel Rodrigues da Silva Junior
Summary: Socioeconomic and demographic factors, lifestyle, and cultural characteristics may have an important impact on genetic damage. This study analyzed the association between a set of factors and genetic damage by studying populations in southern Brazil. The results showed that age had a weak association with genetic damage, while factors such as skin color, occupational exposure, drug use, exposure to radiation, and the cultural habit of consuming chimarrao were found to be associated with genetic damage. Yerba mate consumption was identified as a confounding factor in cytogenetic studies in the southern region of South America.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Food Science & Technology
Concepcion Medrano-Padial, Maria Puerto, Ana Isabel Prieto, Nahum Ayala, Pauline Beaumont, Caroline Rouger, Stephanie Krisa, Silvia Pichardo
Summary: This study investigated the in vivo genotoxic effects of rats orally exposed to different doses of ST-99 and found no genotoxicity in the cells isolated from stomach, liver, and blood. Analytical studies confirmed the presence of stilbenes and their metabolites in plasma and tissues, supporting the safety profile of ST-99 for potential application as a preservative in the wine industry.
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Chemistry, Multidisciplinary
Adriana Rodriguez-Garraus, Maria Alonso-Jauregui, Ana-Gloria Gil, Inigo Navarro-Blasco, Adela Lopez de Cerain, Amaya Azqueta
Summary: A new material composed of kaolin base with silver nanoparticles was developed as an alternative to antibiotics in animal feed. In an in vivo geno-toxicological evaluation in rats, the material showed no adverse effects when administered orally at a dose of 2000 mg/kg b.w. for 28 days. The material did not induce micronuclei or DNA damage in various tissues, and silver content in target organs confirmed the negative results.
Article
Food Science & Technology
Antonio Cascajosa-Lira, Maria Puerto, Ana I. Prieto, Silvia Pichardo, Leticia Diez-Quijada Jimenez, Alberto Banos, Enrique Guillamon, Rosario Moyano, Veronica Molina-Hernandez, Angeles Jos, Ana M. Camean
Summary: This study confirmed the lack of in vivo genotoxicity of PTS at the doses tested, indicating that it is a promising natural alternative in animal feed without adverse effects on genetic material.
Article
Nutrition & Dietetics
Lea Beltzig, Anna Frumkina, Christian Schwarzenbach, Bernd Kaina
Summary: The study compared the cytotoxic and genotoxic activity of native curcumin solubilised in ethanol (Cur-E) with curcumin embedded in micelles (Cur-M) and found that they had the same toxic effects in cells, requiring continuous exposure for inducing cell death. The effective concentration in cells was much higher than achievable in vivo, suggesting that native curcumin and curcumin in a micellar formulation at the ADI level are not cytotoxic/genotoxic, indicating a wide margin of safety.
Article
Environmental Sciences
Francielen Barroso Aragao, Ian Drumond Duarte, Dayana Effgen Fantinato, Iasmini Nicoli Galter, Graciele Lurdes Silveira, Gabriela Barreto dos Reis, Larissa Fonseca Andrade-Vieira, Silvia Tamie Matsumoto
Summary: The study showed that a tebuconazole-based fungicide may have phytotoxic, cytotoxic, and genotoxic effects on the roots and meristematic cells of L. sativa at certain concentrations.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Danielle Mulder, Cornelius Johannes Francois Taute, Mari van Wyk, Pieter J. Pretorius
Summary: The study found that functionalized GNPs caused genotoxicity in HepG2 cells, but the cells were able to initiate repair mechanisms and recover DNA damage, except for two functionalization chemistries.
Article
Biochemistry & Molecular Biology
Ewelina Krol, Zbigniew Krejpcio, Monika Okulicz, Hanna Smigielska
BIOLOGICAL TRACE ELEMENT RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Pandora E. White, Ewelina Krol, Artur Szwengiel, Malgorzata Tubacka, Dawid Szczepankiewicz, Halina Staniek, John B. Vincent, Zbigniew Krejpcio
Summary: The study investigated the combined effects of trivalent chromium and bitter melon in high-fat-fed streptozotocin-induced diabetic rats, revealing a potential nutritional antagonistic effect between the two substances. While bitter melon showed some improvement in body mass gain, blood glucose, and LDL cholesterol values, trivalent chromium did not significantly impact glucose and lipid metabolism in the experimental rats. This suggests that the combination of trivalent chromium and bitter melon may not provide additive benefits in treating insulin resistance and diabetes in this animal model.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Nutrition & Dietetics
Jakub Michal Kurek, Ewelina Krol, Zbigniew Krejpcio
Summary: The study found that dietary supplementation with steviol glycosides can normalize lipid metabolism, alleviate internal organ damage in diabetic rats, and have no significant effect on blood glucose, insulin, and insulin resistance indices.
Article
Food Science & Technology
Anna Rogaska, Julita Regula, Joanna Suliburska, Zbigniew Krejpcio
Article
Biochemistry & Molecular Biology
Anna Rogaska, Julita Regula, Joanna Suliburska, Zbigniew Krejpcio
Summary: The study aimed to design gluten-free bread with high mineral bioavailability, with results showing that additives increased the bioavailability of minerals in gluten-free bread, and different types of flour influenced the release of various minerals.
Article
Biochemistry & Molecular Biology
Anna Przybylska-Balcerek, Tomasz Szablewski, Lidia Szwajkowska-Michalek, Dariusz Swierk, Renata Cegielska-Radziejewska, Zbigniew Krejpcio, Elzbieta Suchowilska, Lukasz Tomczyk, Kinga Stuper-Szablewska
Summary: Elderberry fruit extracts are rich in phenolic acids and flavonoids, which determine their antibacterial activity. The extracts showed activity against selected strains of bacteria, with chlorogenic acid, sinapic acid, t-cinnamic acid, rutin, and quercetin being the predominant compounds influencing the high antibacterial activity.
Article
Nutrition & Dietetics
Aleksandra Szlas, Jakub Michal Kurek, Zbigniew Krejpcio
Summary: L-arginine is a safe endogenous amino acid involved in various regulatory functions in the body. It may be helpful in managing disturbed metabolism, regulating blood pressure, and alleviating type 2 diabetes symptoms, but the mechanisms underlying these effects are not fully understood.
Article
Food Science & Technology
Jakub Michal Kurek, Joanna Zielinska-Wasielica, Katarzyna Kowalska, Zbigniew Krejpcio, Anna Olejnik
Summary: This study demonstrates the inhibitory effect of stevioside and steviol on adipogenesis and lipogenesis, leading to decreased lipid accumulation. Additionally, they can enhance glucose uptake in insulin-resistant cells and alleviate symptoms of insulin resistance.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Chemistry, Medicinal
Jakub Kurek, Ewelina Krol, Halina Staniek, Zbigniew Krejpcio
Summary: The study evaluated the effects of stevioside combined with L-arginine and chromium(III) on mild type 2 diabetic rats. The results showed improvements in blood glucose levels, insulin resistance indices, and VLDL-C concentrations with stevioside supplementation. Stevioside was more effective than rebaudioside A in reducing these markers.
Article
Biochemistry & Molecular Biology
Kinga Stuper-Szablewska, Tomasz Szablewski, Anna Przybylska-Balcerek, Lidia Szwajkowska-Michalek, Michal Krzyzaniak, Dariusz Swierk, Renata Cegielska-Radziejewska, Zbigniew Krejpcio
Summary: Plant extracts are valuable sources of bioactive compounds that can be used in various industries. This study investigated the content of selected bioactive compounds in extracts from different plant materials, and found that they have potential antimicrobial activity. The tested plant materials, including bitter melon, elderberry, wild rose, mountain ash, guelder rose, and sea buckthorn, contain various bioactive compounds and exhibit antibacterial effects.
Article
Plant Sciences
Magdalena Zielinska-Dawidziak, Wojciech Bialas, Dorota Piasecka-Kwiatkowska, Halina Staniek, Przemyslaw Niedzielski
Summary: Plant ferritin in legumes can be increased by sprouting in FeSO4 solution. In vitro digestion showed that more ferritin was released in gastric fluid than in intestinal fluid.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Medicine, Research & Experimental
Jakub Michal Kurek, Joanna Mikolajczyk-Stecyna, Zbigniew Krejpcio
Summary: This study reveals the potential of steviol glycosides in regulating lipid metabolism and shows their impact on specific gene expression. However, further research, including human trials, is needed to confirm these effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Environmental Sciences
Ewelina Krol, Zbigniew Krejpcio
Summary: Diabetes mellitus is a metabolic disease that affects carbohydrate and lipid levels, as well as the body's mineral balance. This study found that Cr(III) is a potential hypoglycaemic element. Supplementation with Cr(III) complexes partially normalized the levels of magnesium and phosphorus in the heart, liver, and spleen of diabetic rats. However, these compounds did not influence the antioxidant status.
JOURNAL OF ELEMENTOLOGY
(2023)