Article
Rheumatology
Priyanka Ballal, Christine Peloquin, Cindy Germaine Boer, Tuhina Neogi
Summary: This study suggests that warfarin use is associated with a higher risk of knee and hip replacements compared to DOAC use. Furthermore, longer duration of warfarin use is linked to an increased risk of joint replacement.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Orthopedics
Yasmin D. Hailer, Johan Karrholm, Niclas Eriksson, Lars Holmberg, Nils P. Hailer
Summary: This study suggests that there is no statistically significant overall increased risk of cancer in young patients undergoing total hip arthroplasty (THA). However, there may be a slightly increased risk for specific cancers, which warrants further investigation.
Article
Orthopedics
Rafael Pinedo-Villanueva, Spyros Kolovos, Edward Burn, Antonella Delmestri, Lindsay K. K. Smith, Andrew Judge, Sarah R. R. Kingsbury, Martin H. H. Stone, Philip G. G. Conaghan
Summary: Follow-up visits after primary hip or knee replacement surgery have been recommended, but their benefits have not been specifically examined. This study found that patients attending follow-up visits had a higher risk of revision surgery.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Article
Endocrinology & Metabolism
Jiatian Li, Na Lu, Houchen Lyu, Guanghua Lei, Chao Zeng, Jie Wei, Yilun Wang, Dongxing Xie
Summary: This population-based cohort study suggests an independent association between the use of proton pump inhibitors (PPIs) and an increased risk of hip fracture in individuals with peptic ulcer disease (PUD).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Inna Y. Y. Gong, Kelvin K. W. Chan, Lorraine L. Lipscombe, Matthew C. Cheung, Lee Mozessohn
Summary: Patients with cancer have a higher risk of fractures compared to non-cancer controls.
BRITISH JOURNAL OF CANCER
(2023)
Article
Geriatrics & Gerontology
Warrington W. Q. Hsu, Chor-Wing Sing, Gloria H. Y. Li, Kathryn C. B. Tan, Bernard M. Y. Cheung, Janus S. H. Wong, Ian Chi-Kei Wong, Ching-Lung Cheung
Summary: This study found a higher immediate risk of major adverse cardiovascular events (MACEs) in patients with hip fractures compared to those without. The risk was highest in the first 90 days post-fracture and decreased over time, suggesting the importance of early evaluation and management in older adults with hip fractures to reduce subsequent MACE risk.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Orthopedics
Lars L. Hermansen, Bjarke Viberg, Lars Hansen, Soeren Overgaard
Summary: The true 2-year cumulative incidence of dislocation after primary THAs performed in Denmark between 2010 and 2014 was found to be 3.5%. Age, sex, ASA score, head size and type, fixation method, and surgical approach were identified as independent significant factors for dislocation. Comprehensive search algorithms are needed to accurately report complications in national registers.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2021)
Article
Gastroenterology & Hepatology
Devin Abrahami, Emily Gibson McDonald, Mireille E. Schnitzer, Alan N. Barkun, Samy Suissa, Laurent Azoulay
Summary: The study found that the use of PPIs is associated with an increased risk of gastric cancer compared with the use of H2RAs, although the absolute risk remains low.
Article
Orthopedics
Sonia Rojewski, Marianne Westberg, Lars Nordsletten, Haakon E. Meyer, Kristin Holvik, Ove Furnes, Anne Marie Fenstad, Jesper Dahl
Summary: This study investigated the relationship between individual postvaccination immune responses and the subsequent risk of total hip arthroplasty (THA) due to idiopathic osteoarthritis (OA) or rheumatoid arthritis (RA). The results showed that in men, there was no association between tuberculin skin test (TST) results and the risk of THA due to OA, while in women, a strong positive TST was associated with a reduced risk of THA.
OSTEOARTHRITIS AND CARTILAGE
(2023)
Article
Endocrinology & Metabolism
N. R. Gadgaard, C. Varnum, R. G. H. H. Nelissen, C. Vandenbroucke-Grauls, H. T. Sorensen, A. B. Pedersen
Summary: The impact of comorbidity on infection risk among hip fracture patients is not clear, but a high incidence of infection was found. Comorbidity was identified as an important risk factor for infection up to 1 year after surgery. The results indicate a need for increased investment and support for patients with high comorbidity in pre- and postoperative programs.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Orthopedics
Seper Ekhtiari, Daniel Pincus, Ruth Croxford, Jodi M. Gatley, Amir Khoshbin, Amit Atrey, J. Michael Paterson, Bheeshma Ravi
Summary: This study assessed the impact of the COVID-19 pandemic and the shift towards outpatient surgery on access to joint replacement for marginalized patients. The findings showed that fewer marginalized patients have undergone joint replacement surgery since the pandemic.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Endocrinology & Metabolism
Houyu Zhao, Zhike Liu, Lin Zhuo, Peng Shen, Hongbo Lin, Yexiang Sun, Siyan Zhan
Summary: This study found no association between the use of sulfonylurea and cancer risk in patients with type 2 diabetes mellitus. Further studies using data from the Chinese population are needed to evaluate the association between sulfonylurea use and cancer risk.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Health Care Sciences & Services
Ji Eun Lee, Kyungdo Han, Juhwan Yoo, Yohwan Yeo, In Young Cho, Belong Cho, Hyuktae Kwon, Dong Wook Shin, Jong Ho Cho, Yong-Moon Park
Summary: This study investigated the association between variability in metabolic parameters and esophageal cancer incidence using large nationally representative data. The results showed that a high variability of metabolic parameters was associated with an increased risk of esophageal cancer, and further studies are needed to replicate these findings in other populations.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Lina Zabuliene, Auguste Kaceniene, Laura Steponaviciene, Donata Linkeviciute-Ulinskiene, Rimantas Stukas, Rokas Arlauskas, Rasa Vanseviciute-Petkeviciene, Giedre Smailyte
Summary: This study found a significantly increased risk of EC in diabetic women compared to the general population, especially in younger patients at T2DM diagnosis and those with longer duration of diabetes. The use of glucose-lowering medication combinations, except for insulin only, was associated with a higher EC risk in diabetic women.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Youhyun Song, Hye Sun Lee, Goeun Park, Sang-Wook Kang, Ji Won Lee
Summary: This study aimed to investigate the risk of dyslipidemia in patients with thyroid cancer (TC) compared to the general population without TC. The results showed no significant difference in dyslipidemia risk between TC patients and the general population, both in prospective and retrospective analyses.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Sakari Pietilainen, Erno Smedberg, Inari Laaksonen, Mikko S. Venalainen, Petteri Lankinen, Keijo T. Makela
Summary: The study found that metal ion levels in the blood of metal-on-metal total hip arthroplasty patients may change over time, but the clinical outcomes remain relatively stable. Despite this, continued follow-up of these devices is recommended due to the relatively low implant survival rates.
Article
Surgery
Sakari Pietilainen, Miro Lindstrom, Inari Laaksonen, Mikko S. Venalainen, Petteri Lankinen, Keijo T. Makela
Summary: This study aimed to assess the long-term changes in metal ion levels and clinical outcomes in patients with a Birmingham hip arthroplasty. The results showed that frequent metal ion measurements were not beneficial for patients. Although the occurrence of metal-related adverse events was relatively high, most of them did not require surgery.
SCANDINAVIAN JOURNAL OF SURGERY
(2022)
Article
Orthopedics
O. K. Leino, K. K. Lehtimaki, K. Makela, V. Aarimaa, E. Ekman
Summary: This study aimed to identify the trends in the incidence and methods of treatment of proximal humeral fractures (PHFs) in Finland. The results showed that the incidence of PHFs is steadily increasing, particularly in elderly females, while the incidence of operative treatment is now decreasing.
BONE & JOINT JOURNAL
(2022)
Article
Orthopedics
Sakari Pietilainen, Axel Linnovaara, Mikko S. Venalainen, Heikki Mantymaki, Inari Laaksonen, Petteri Lankinen, Keijo T. Makela
Summary: This study reports long-term metal ion levels and clinical outcomes after ReCap-Magnum THA. The results showed a continuous decrease in whole blood Cr and Co levels, with a relatively high occurrence of metal-related adverse events but a low need for revision surgery.
Article
Cell Biology
Arjen Gebraad, Roope Ohlsbom, Juho J. Miettinen, Promise Emeh, Toni-Karri Pakarinen, Mikko Manninen, Antti Eskelinen, Kirsi Kuismanen, Ana Slipicevic, Fredrik Lehmann, Nina N. Nupponen, Caroline A. Heckman, Susanna Miettinen
Summary: This study investigated the cytotoxicity of Melflufen on BMSCs and its effects on BMSC differentiation and the formation of vascular networks. The results showed that Melflufen has significant cytotoxic effects on BMSCs and affects their differentiation, which could potentially impact therapy outcomes.
Article
Orthopedics
Anssi Arimaa, Jani Knifsund, Heli Keskinen, Mika Kivimaki, Ville Aalto, Tuula Oksanen, Keijo Makela, Jussi Vahtera, Petteri Lankinen
Summary: This study identified factors associated with the timing of return to work after anterior cruciate ligament reconstruction and found that older age, lower occupational status, and preoperative sick leaves were correlated with a longer duration of sick leave.
Article
Multidisciplinary Sciences
Oskari Pakarinen, Mari Karsikas, Aleksi Reito, Olli Lainiala, Perttu Neuvonen, Antti Eskelinen
Summary: This study aimed to build a prediction model for early revision for dislocation after primary total hip arthroplasty (THA) using two different statistical methods. The results showed that both models had low predictive capability and modest discrimination. Therefore, the risk of dislocation should be kept in mind in every primary THA, regardless of the presence of predisposing factors.
Article
Orthopedics
Antton Palomaki, Matias Hemmila, Markus Matilainen, Antti Eskelinen, Jaason Haapakoski, Ari-Pekka Puhto, Jukka Kettunen, Konsta Pamilo, Mikko Manninen, Anna Vasara, Keijo T. Makela
Summary: In comparing the long-term outcomes of 28-mm head M2a RingLoc MoM THA and 28-mm MoP THA, the study found no significant differences in survivorship rates. Further research is needed to assess the long-term effects of metal ion levels and radiological data before formal recommendations can be made.
Article
Orthopedics
Tero Irmola, Ville Ponkilainen, Keijo T. Makela, Otto Robertsson, Annette W-Dahl, Ove Furnes, Anne M. Fenstad, Alma B. Pedersen, Henrik M. Schroder, Mika J. Niemelainen, Antti Eskelinen
Summary: This study aimed to compare patient demographics, methods, and revision rates in primary knee arthroplasties among the 4 Nordic countries, and evaluate the impact of Nordic collaboration. The study found a slowing growth of knee arthroplasty incidence in the Nordic countries after 2010, with Finland having the highest incidence. There were substantial differences among the countries in surgical methods and revision risks.
Article
Orthopedics
Oskari Leino, Heli Keskinen, Inari Laaksonen, Keijo Makela, Eliisa Loyttyniemi, Elina Ekman
Summary: This study investigates the incidence and treatment of Achilles tendon ruptures in Finland and finds that the incidence has increased while the use of operative treatment has decreased.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Article
Orthopedics
Rasmus Tyrsted Mikkelsen, Soren Overgaard, Alma B. Pedersen, Johan Karrholm, Ola Rolfson, Anne Marie Fenstad, Ove Furnes, Geir Hallan, Keijo Makela, Antti Eskelinen, Claus Varnum
Summary: This study compared the survivorship of different bearing materials (metal-on-metal, ceramic-on-ceramic, ceramic-on-highly-crosslinked-polyethylene, and metal-on-highly-crosslinked-polyethylene) in young patients undergoing total hip arthroplasty. The results showed that metal-on-metal bearings had a higher risk of revision, while metal-on-highly-crosslinked-polyethylene had better revision-free survival.
Article
Orthopedics
Hannes Keemu, Kasperi J. Alakyla, Riku Klen, Valtteri J. Panula, Mikko S. Venalainen, Jaason J. Haapakoski, Antti P. Eskelinen, Konsta Pamilo, Jukka S. Kettunen, Ari-Pekka Puhto, Anna Vasara, Laura L. Elo, Keijo Makela
Summary: This study assessed the risk factors for revision due to periprosthetic joint infection (PJI) after total knee arthroplasty (TKA) using data from the Finnish Arthroplasty Register. The analysis showed that not using an antimicrobial incise drape and using a drainage increased the risk of revision surgery. Specializing in TKA reduced operative time and the rate of PJI.
Article
Orthopedics
Havard Dale, Anne Marie Fenstad, Geir Hallan, Soren Overgaard, Alma B. Pedersen, Nils P. Hailer, Johan Karrholm, Ola Rolfson, Antti Eskelinen, Keijo T. Makela, Ove Furnes
Summary: This study analyzed the risk, rates, and timing of revision due to infection after primary total hip arthroplasty (THA) in the Nordic countries from 2004 to 2018. The findings showed an increasing trend in the risk of revision due to infection, with a significant increase within 90 days after surgery. Further research is needed to determine the reasons behind this increase and its implications.
Editorial Material
Orthopedics
Nils P. Hailer, Ove Furnes, Keijo Makela, Soren Overgaard
Article
Sport Sciences
Maarit Janhunen, Niina Katajapuu, Juha Paloneva, Konsta Pamilo, Airi Oksanen, Hannes Keemu, Mikko Karvonen, Mika Luimula, Raija Korpelainen, Timo Jämsä, Hannu Kautiainen, Keijo Makela, Ari Heinonen, Eeva Aartolahti
Summary: This study aimed to investigate the effects of 4 months of customised, home-based exergaming on physical function and pain after total knee replacement (TKR) compared with standard exercise protocol. The results showed that training at home with customised exergames was more effective in mobility and early satisfaction as well as equally effective in pain and other physical functions compared to standard exercise.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2023)
