Article
Clinical Neurology
Serena Zampino, Farooq H. Sheikh, Joban Vaishnav, Daniel Judge, Baohan Pan, Amrita Daniel, Emily Brown, Gigi Ebenezer, Michael Polydefkis
Summary: This study describes the neurological and cardiac characteristics of common US ATTR mutations V122I, L58H, and late-onset V30M in patients with hereditary transthyretin amyloidosis. The results indicate that there are clinical differences among these mutations, including age of onset, sex distribution, neurological impairment scores, and cardiac indicators. These findings have important implications for the diagnosis and clinical management of ATTR mutations.
Article
Clinical Neurology
Luca Leonardi, Eleonora Galosi, Fiammetta Vanoli, Alessandra Fasolino, Giuseppe Di Pietro, Marco Luigetti, Mario Sabatelli, Laura Fionda, Matteo Garibaldi, Girolamo Alfieri, Antonio Lauletta, Stefania Morino, Marco Salvetti, Andrea Truini, Giovanni Antonini
Summary: The study found that patients with ATTRv-PN and asymptomatic carriers show early nerve pathological and functional changes, with skin biopsy and QST providing valuable insights into disease onset and progression.
NEUROLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Qiaoyuan Deng, Qingguo Feng, Peipei Jing, Donglin Ma, Mengting Li, Yanli Gong, Yantao Li, Feng Wen, Yongxiang Leng
Summary: To extend the lifespan of artificial hip joints, a Cu-doped titanium nitride (TiNX-Cu) film with autoantifriction properties is deposited on a CoCrMo alloy. The Cu in TiNX-Cu quickly binds to protein molecules, forming a stable protein layer. Under shear stress, the proteins decompose into hydrocarbon fragments, which are transformed into graphite-like carbon tribofilms with antifriction property. This film can lubricate and increase the wear resistance of prosthetic devices, thus prolonging their lifespan.
Article
Clinical Neurology
Sandra S. S. Gylfadottir, Mustapha Itani, Alexander G. G. Kristensen, Jens R. R. Nyengaard, Soren Hein Sindrup, Troels S. S. Jensen, Nanna B. B. Finnerup, Pall Karlsson
Summary: This study assessed and compared the use of corneal confocal microscopy (CCM), intraepidermal nerve fiber density (IENFD), cold detection threshold (CDT), and warm detection threshold (WDT) in the diagnosis of diabetic polyneuropathy (DPN) in patients with type 2 diabetes. It was found that CCM had the lowest sensitivity compared with other small fiber measures.
Article
Multidisciplinary Sciences
Jia-Ruei Yu, Yi-Chou Hou, Jen-Fen Fu, I-Kuan Wang, Ming-Jen Chan, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Huang-Yu Yang, Ching-Wei Hsu, Tzung-Hai Yen
Summary: This study analyzed the clinical patterns and outcomes of elderly patients with organophosphate intoxication over a period of 9 years. The most common organophosphates involved were chlorpyrifos and methamidophos. Treatment included atropine and pralidoxime therapies, with all cases developing acute cholinergic crisis. Complications such as respiratory failure, aspiration pneumonia, and shock were more common in nonsurvivors, with shock identified as a significant predictor of mortality. The mortality rate was 19.7%, with complications including acute cholinergic crisis, intermediate syndrome, and delayed neuropathy.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
Oystein Dunker, Margreth Grotle, Marie Bu Kvaloy, Martin Uglem, Sissel Loseth, Ina Elen Hjelland, Inge Petter Kleggetveit, Sara Maria Allen, Maria Dehli Vigeland, Rikke Munk Killingmo, Trond Sand, Kristian Bernhard Nilsen
Summary: This study aimed to investigate the diagnostic accuracy of 3 tools commonly used to differentiate between neuropathic and nonneuropathic pain. The results showed that neither DN4, painDETECT, nor S-LANSS can be confidently used to assess neuropathic pain.
Review
Endocrinology & Metabolism
Sanjeev Sharma, Gerry Rayman
Summary: Diabetes sensory polyneuropathy (DSPN), a complication of diabetes, affects up to 50% of patients in their lifetime, with approximately 20% suffering from painful neuropathic pain. DSPN, regardless of pain, causes significant morbidity, reducing quality of life and increasing lower limb amputations, and is associated with increased mortality. This article discusses the varied clinical presentation of DSPN, the importance of excluding key differential diagnoses, current diagnostic techniques for large and small neural fibers along with their limitations and advantages, and the management of DSPN including newer pharmacotherapies.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Mechanical
Zhiyuan Yu, Liangchi Zhang
Summary: Wear of the bearing surfaces of an artificial hip joint (AHJ) is a major cause of premature prosthesis failure. This study aims to develop an effective mechanism model to investigate the wear at the bearing surfaces of a hip joint prosthesis under three-dimensional motion and loading conditions during patient's walking activities. Finite element method was used to construct femoral heads and acetabular cups of various dimensions and explore the effect of design parameters on the contact wear of their bearing surfaces. Analysis of the contact area trajectory revealed that the sliding trajectory mainly concentrated in specific regions of the acetabular cup. After 106 cycles of gait walking, an AHJ with thicker cup thickness or smaller femoral head radius had less volumetric wear, while that with thinner cup thickness or larger femoral head radius had less linear wear.
Article
Materials Science, Multidisciplinary
Renquan Ji, Fei Chen, Rongmin Ying, Li Zhang
Summary: This study examines the impact of different contact surface parameters on the wear of ceramic-titanium alloy artificial hip joints through simulations and experimental testing. The results show that the contacting surfaces exhibit a crescent-shaped composition and the initial variation in friction coefficient has minimal influence on wear rate. A surface roughness of 150 nm shows the least wear and the best anti-wear performance. The study also provides valuable insights into the influence of friction coefficients on the wear of artificial joint surfaces.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ming Ni, Xiaoyi Wen, Wen Chen, Yuqing Zhao, Yuan Yuan, Piaoe Zeng, Qizheng Wang, Yong Wang, Huishu Yuan
Summary: This study investigates the feasibility of using deep learning to diagnose and classify labral injuries on MRI. The results show that deep learning can assist radiologists in diagnosing and classifying labral injuries.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Endocrinology & Metabolism
Chenxi Li, Weimin Wang, Wenyu Ni, Yu Jin, Simin Guo, Jiewen Jin, Chuhui Chen, Wei Chen, Yan Bi, Dalong Zhu
Summary: The clinical characteristics and outcomes of small fiber neuropathy (SFN) in Chinese patients with type 2 diabetes mellitus (T2DM) were investigated in this study. Better islet function and cardiovascular autonomic function were observed in patients with pure SFN compared with mixed DPN, and the metabolic and neurological indexes remained relatively stable in the patients with pure SFN during the follow-up.
Article
Clinical Neurology
Gary R. Zirpoli, Khosro Farhad, Madeleine C. Klein, Sean Downs, Max M. Klein, Anne Louise Oaklander
Summary: The diagnosis of small-fiber neuropathy (SFN) is challenging due to its subjective symptoms and lack of confirmatory testing. The Massachusetts General Hospital Neuropathy Exam Tool (MAGNET) was developed as a predictive examination to assist in the diagnosis of SFN.
Article
Thermodynamics
C. H. Hor, C. P. Tso, G. M. Chen
Summary: This study numerically investigates the temperature rise induced exclusively by viscous dissipation effect in synovial fluid, reaching a maximum of 2.8 degrees Celsius within 1 hour. It recommends inclusion of viscous dissipation effect in artificial hip joint model studies.
CASE STUDIES IN THERMAL ENGINEERING
(2021)
Article
Clinical Neurology
Noor E. Taams, Maria J. Knol, Rens Hanewinckel, Judith Drenthen, Hieab H. H. Adams, Pieter A. van Doorn, Mohammad Arfan Ikram
Summary: This study found genetic associations between diabetes, BMI, vitamin B12 levels, alcohol intake, and chronic axonal polyneuropathy, providing evidence for causal relationships between these well-known clinical risk factors and polyneuropathy.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Sun Woong Kim, Young Cheol Yoon, Duk Hyun Sung
Summary: This study described and analyzed intraneural ganglion cysts (INGCs) originating from the hip joint. The results showed generally favorable treatment outcomes regardless of the treatment method. Physicians should pay attention to the possibility of INGCs originating from the hip joint as a cause of nontraumatic pain.
