Article
Endocrinology & Metabolism
Ulla Kampmann, Esben S. Lauritzen, Niels Grarup, Niels Jessen, Torben Hansen, Niels Moller, Julie Stoy
Summary: The study found that acute administration of high doses of melatonin may reduce insulin sensitivity, especially in certain genotype carriers.
JOURNAL OF PINEAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
John B. Vincent
Summary: A recent report suggests that the active site of the beta subunit of mitochondrial ATP synthase is likely where Cr(III) acts, independent of insulin signaling. This finding sheds light on the mechanism of Cr(III) at a molecular level in rodents given supra-nutritional levels. However, it also raises questions regarding the relationship to chromium supplementation in rodents and the current understanding of chromium(III) transport and detoxification systems.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mary D. Adu, Catherine P. Bondonno, Benjamin H. Parmenter, Marc Sim, Raymond J. Davey, Kevin Murray, Simone Radavelli-Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: This study examined the association between flavonoid intake and measures of glucose tolerance and insulin sensitivity in adults, as well as the long-term risk of type 2 diabetes. The results suggest that consuming flavonoid-rich foods may protect against type 2 diabetes by improving glucose tolerance and insulin sensitivity.
Article
Nutrition & Dietetics
Karoline T. Fenne, Matthieu Clauss, Daniela Schaefer Olstad, Egil I. Johansen, Jorgen Jensen
Summary: Caffeine impairs glucose tolerance and exercise improves glucose homeostasis. This study investigated the effects of caffeine on glucose tolerance the morning after aerobic exercise. The results showed that caffeine increased glucose AUC regardless of exercise.
Article
Multidisciplinary Sciences
Srdana Dordievski, Elvira L. Vukasinovic, Tatjana V. Celic, Ivan Pihler, Marko Kebert, Danijela Kojic, Jelena Purac
Summary: This study found that dietary supplementation of spermidine improved the health of honey bees by increasing their survival rate and average lifespan, reducing oxidative stress, enhancing antioxidant capacity, and influencing polyamine content and gene expression. It provides important information on possible strategies for improving honey bee health by introducing spermidine into their diet.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Xueyan Hu, Xinyue Wang, Qiqi Liu, Jin Wu, Haoqi Zhang, Anila Khalique, Zhiyuan Sun, Rui Chen, Jing Wei, Hongbo Li, Deling Kong, Jie Zhuang, Xiyun Yan, Xinglu Huang
Summary: The fully synthetic cell system, integrating biomimetic nanozymes into giant unilamellar vesicles, successfully mimics intracellular oxidative stress pathways and induces tumor cell death by sensing and responding to external chemical signals.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Medicinal
Zohre Bateni, Hamid Reza Rahimi, Mehdi Hedayati, Shila Afsharian, Razieh Goudarzi, Golbon Sohrab
Summary: This study demonstrated that supplementation with nano-micelle curcumin significantly reduced serum triglyceride levels and HOMA-beta in MetS patients. However, there were no significant differences in other anthropometric measurements, blood pressure, and lipid profile variables at the end of the study.
PHYTOTHERAPY RESEARCH
(2021)
Article
Agricultural Engineering
Muhammad Ahmad, Ejaz Ahmad Waraich, Usman Zulfiqar, Aman Ullah, Muhammad Farooq
Summary: This study demonstrated that the application of thiourea can improve heat tolerance in camelina, increase seed yield, and protect plants from oxidative damage. Additionally, thiourea application was more effective at the reproductive stage, and genotype 618 showed higher tolerance to heat stress compared to genotype 611.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Emad A. S. Al-Dujaili, Ciara Casey, Angela Stockton
Summary: This study investigated the effects of pomegranate extract on cardiovascular risk factors. The results showed that pomegranate extract intake improved antioxidant and oxidative stress status and attenuated some cardiovascular risk factors.
Article
Biochemistry & Molecular Biology
Takujiro Homma, Sho Kobayashi, Hideyo Sato, Junichi Fujii
Summary: Mitochondrial superoxide plays a key role in ferroptosis induced by cysteine starvation, with suppression of complex III superoxide production effectively protecting cells from lipid peroxidation.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Peripheral Vascular Disease
Madeleine R. Paterson, Kristy L. Jackson, Malathi S. I. Dona, Gabriella E. Farrugia, Bruna Visniauskas, Anna M. D. Watson, Chad Johnson, Minolfa C. Prieto, Roger G. Evans, Fadi J. Charchar, Alexander R. Pinto, Francine Z. Marques, Geoffrey A. Head
Summary: miR-181a is downregulated in the kidneys of hypertensive patients and mice. Deletion of miR-181a/b-1 in mice leads to increased blood pressure and salt sensitivity. Single-nuclei RNA sequencing revealed dysregulation of genes related to immune system, inflammatory response, and nerve development in the kidneys of KO mice.
Article
Biochemistry & Molecular Biology
Yantong Meng, Qingjia Meng, Chang Li, Mengqian Wang, Siqi Li, Jian Ying, Hao Zheng, Shuqun Bai, Yong Xue, Qun Shen
Summary: Both partially peeled hulless barley (PHB) and whole grain hulless barley (WHB) interventions improved glucose metabolism and gut microbiota dysbiosis in obese mice induced by a high-fat diet.
Article
Peripheral Vascular Disease
Theodore W. Kurtz, R. Curtis Morris Jr, Michal Pravenec, Heidi L. Lujan, Stephen E. DiCarlo
Summary: Previous studies suggest that hyperaldosteronism initiates hypertension by increasing sodium retention and blood volume. However, this study found that aldosterone can also promote salt sensitivity and initiation of salt-dependent hypertension by increasing peripheral vascular resistance and decreasing cardiac output.
Review
Infectious Diseases
Qigang Huang, Yingwei Ding, Chao Fang, Hao Wang, Laifa Kong
Summary: Sepsis is a syndrome characterized by multi-organ dysfunction triggered by abnormal immune responses. Recent research has shown that abnormal metabolism of trace nutrients, such as iron, plays a significant role in the pathogenesis of sepsis. Ferroptosis, a form of cell death driven by lipid peroxidation, has been identified as a key mechanism in sepsis and has the potential to reduce inflammation. However, there is a lack of studies investigating the multi-organ dysfunction caused by ferroptosis in sepsis.
INFECTION AND DRUG RESISTANCE
(2023)
Review
Physiology
Lale A. Ertuglu, Fernando Elijovich, Cheryl L. Laffer, Annet Kirabo
Summary: Insulin resistance is closely related to salt sensitivity of blood pressure, affecting nearly 50% of salt sensitive individuals. Immune activation and vascular dysfunction play important roles in the pathogenesis of both conditions.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)