Article
Environmental Sciences
Jeremy Gingrich, David Filipovic, Rory Conolly, Sudin Bhattacharya, Almudena Veiga-Lopez
Summary: The study developed pregnancy-specific PBTK models for BPA and BPS, demonstrating robustness by simulating maternal and fetal experimental data within one standard deviation. Predictive simulations showed fetal accumulation of both bisphenols over time, with steady-state approximation achieving levels of unconjugated BPA comparable to cord blood in human biomonitoring studies.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
James M. Armitage, Lauren Hughes, Alessandro Sangion, Jon A. Arnot
Summary: This study presents the development and comparison of generic PBTK models for humans, which showed consistent results for key toxicokinetic parameters between one-compartment and multi-compartment models, but discrepancies may arise in cases of rapid biotransformation. Differences are most pronounced for neutral organics and least for acidic IOCs.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Rebeka Jereb, Jerneja Opara, Aleksander Bajc, Bostjan Petek
Summary: This study investigates the impact of gastrointestinal physiology on drug bioperformance, showing that variations in pH, fluid volume, bile salt concentration, and transit time can affect drug dissolution and absorption. By developing physiologically based absorption models and conducting virtual clinical trials, the study explores the reasons for variability in drug bioperformance between subjects and proposes ways to optimize drug design and efficacy based on these findings.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Environmental Sciences
Paul Quindroit, Amelie Crepet, Celine Brochot
Summary: Human biomonitoring data provide evidence of exposure to environmental chemicals, and PBPK modelling can help estimate exposure levels. In a study in France, exposure to pyrethroids was estimated based on urinary concentrations of specific metabolites. The study found no significant risks associated with the exposure levels of pyrethroids in the French cohort.
ENVIRONMENTAL RESEARCH
(2021)
Review
Food Science & Technology
Yiwen Li, Fanbin Kong
Summary: This review summarizes the characteristics of gastric and small intestinal motility in humans, as well as the biomechanical and hydrodynamic events related to gut motility. The performance of various dynamic in vitro models in simulating gastrointestinal motility is evaluated.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2022)
Article
Environmental Sciences
Deepika Deepika, Raju Prasad Sharma, Marta Schuhmacher, Vikas Kumar
Summary: The research highlights the adverse effects of PFOS on humans, with variation in accumulation across different age groups. The development of a dynamic age-dependent PBPK model improves the risk assessment of PFOS and its prevention in susceptible age groups.
ENVIRONMENTAL RESEARCH
(2021)
Review
Medicine, Research & Experimental
Hinke Siebinga, Berlinda J. de Wit-van der Veen, Marcel D. M. Stokkel, Alwin D. R. Huitema, Jeroen J. M. A. Hendrikx
Summary: Physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PK) modelling approaches are not widely used in radiopharmaceutical development. However, these methods have great potential for understanding the pharmacokinetics and whole-body distribution of radiopharmaceuticals.
Article
Pharmacology & Pharmacy
Zhongxia Tan, Youxi Zhang, Chao Wang, Le Sun
Summary: This study aimed to develop PBPK models for simulating cefadroxil concentrations in plasma and tissues in mouse, rat, and human, which were validated and demonstrated to be rational and accurate. The models suggest that hPEPT1 is the major transporter responsible for oral absorption of cefadroxil in humans and that plasma concentration-time profiles of cefadroxil are not sensitive to dissolution rates faster than 2 hours.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Elissa Elia, David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: This passage discusses the similarities between the gastrointestinal and genitourinary tracts, which both consist of hollow structures that rely on muscle contractions to facilitate the flow of materials. It describes the anatomy, pathologies, and treatments of these organs, with a particular emphasis on tissue engineering strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Mengting Chen, Ruihu Du, Tao Zhang, Chutao Li, Wenqiang Bao, Fan Xin, Shaozhang Hou, Qiaomei Yang, Li Chen, Qi Wang, An Zhu
Summary: Toxicokinetics plays a crucial role in health risk assessments, and physiologically based toxicokinetic (PBTK) models are powerful tools that quantitatively describe the absorption, distribution, metabolism, and excretion of chemicals in organisms and establish correlations with toxic effects.
Article
Pharmacology & Pharmacy
Takafumi Kato, Tsuyoshi Mikkaichi, Yasushi Yoshigae, Noriko Okudaira, Takako Shimizu, Takashi Izumi, Shuichi Ando, Yoshiaki Matsumoto
Summary: The study evaluates the impact of P-gp efflux on edoxaban absorption in gastrointestinal tracts quantitatively using a PBPK model. The constructed model successfully demonstrates the significant contribution of P-gp in edoxaban's disposition in gastrointestinal tracts.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medicine, General & Internal
Rosa Vaccaro, Arianna Casini, Carola Severi, Antonietta Lamazza, Annamaria Pronio, Rossella Palma
Summary: This study examined biopsy samples of normal gastrointestinal mucosa and ulcerative colitis (UC) patients, and found a decrease in the concentration of 5-HT+ cells in UC patients and an increase in the expression of melatonin-secreting cells in severe cases of the disease.
Article
Chemistry, Multidisciplinary
Zhoumeng Lin, Santosh Aryal, Yi-Hsien Cheng, Andre J. Gesquiere
Summary: This review article critically evaluates existing studies on in vivo pharmacokinetic properties, in vitro cellular uptake and release kinetics, and whole-body physiologically based pharmacokinetic (PBPK) modeling studies of different nanomaterials (NMs). It discusses methods for simulating in vitro and in vivo dosimetry of NMs and shares perspectives on current challenges and future directions. The article proposes a Nano-IVIVE-PBPK framework for high-throughput screening of target dosimetry and potential toxicity of NMs.
Article
Environmental Sciences
Xiaowei Wu, Xiaoli Zhao, Xia Wang, Rouzheng Chen, Peng Liu, Weigang Liang, Junyu Wang, Di Shi, Shixiang Gao
Summary: This study investigates the bioaccessibility of polypropylene microplastic fiber-associated antibiotics (tetracycline and ciprofloxacin) in human gastrointestinal fluids and identifies the primary factors affecting their bioaccessibility. The results indicate that pepsin in gastric fluid and trypsin in intestinal fluid play a significant role in the release of antibiotics from microplastic surfaces.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Raymond Nepstad, Konstantinos Kotzakoulakis, Tor Nordam, JoLynn Carroll
Summary: We propose a novel approach for assessing environmental risks of discharges of produced water, taking into account explicit impact and probability. Our approach combines transport, fate, and toxicokinetic-toxicodynamic models within a super-individual framework, with a probabilistic element obtained from ensemble simulations. By considering location and species specificity, our approach addresses the dynamic nature of exposure and uptake of produced water components in the sea. Using a case study of early life stages of spawning haddock in the Barents Sea, we demonstrate the feasibility of conducting model-based risk assessments that capture the effects of natural variations in environmental conditions. We also discuss the benefits, limitations, and potential for further improvements of our approach.
MARINE POLLUTION BULLETIN
(2023)
Article
Endocrinology & Metabolism
Harshal Deshmukh, Lesa L. Aylward, Martin Rose, Alwyn Fernandes, Peter Sedman, Natalie J. Thatcher, Stephen L. Atkin, Thozhukat Sathyapalan
CLINICAL ENDOCRINOLOGY
(2020)
Article
Surgery
Andrew Atia, Dimitrios Moris, MacKenzie McRae, Song Mingqing, Linda Stempora, Francis Leopardi, Kyha Williams, Jean Kwun, William Parker, Adela R. Cardones, Allan D. Kirk, Linda C. Cendales
TRANSPLANT INTERNATIONAL
(2020)
Article
Immunology
Jaime Fergie, Mina Suh, Xiaohui Jiang, Jon P. Fryzek, Tara Gonzales
Summary: This study found an increase in the burden and severity of respiratory syncytial virus (RSV) hospitalizations and all-cause bronchiolitis hospitalizations among otherwise healthy 29-34 weeks' gestational age infants aged <6 months after 2014. The American Academy of Pediatrics' recommendation change regarding palivizumab usage may have contributed to this increase.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Uwe Scheuermann, Elisabeth R. Seyferth, Nader Abraham, Samuel J. Kesseli, Samantha E. Halpern, Minghua Zhu, Mingqing Song, Matthew G. Hartwig, William Parker, Jean Kwun, Anne D. Cherry, Jaewoo Lee, Andrew S. Barbas
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Legal
Chad M. Thompson, Douglas A. Donahue, Cheryl Hobbs, Yanina Costecalde, Allison Franzen, Mina Suh, Deborah M. Proctor, Mark A. Harris
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2020)
Article
Surgery
Dimitrios Moris, Jun Wang, Maria Angelica Selim, Mingqing Song, Linda Stempora, William Parker, Allan D. Kirk, Linda C. Cendales
Summary: By transplanting hind limb grafts from C3H donors to different groups of C57BL/6 recipients, researchers found that rejection of grafts was delayed in the absence of lymph nodes or spleen. This study demonstrates the importance of the lymphatic system in the rejection process of vascularized composite allotransplants.
TRANSPLANT INTERNATIONAL
(2021)
Article
Pediatrics
Zaid Haddadin, Danielle A. Rankin, Loren Lipworth, Mina Suh, Rendie McHenry, Anna Blozinski, Seifein Salib George, Kailee N. Fernandez, Rebekkah Varjabedian, Andrew J. Spieker, Donald S. Shepard, Natasha B. Halasa
Summary: This study aimed to evaluate the distribution, clinical presentations, and severity of common acute respiratory infections viruses in infants across 3 clinical settings. The most commonly detected viruses were rhinovirus/enterovirus, respiratory syncytial virus, and influenza, with RSV causing the highest disease severity.
JOURNAL OF PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Navneet Suda, Jasmine Cendejas Hernandez, John Poulton, John P. Jones, Zacharoula Konsoula, Caroline Smith, William Parker
Summary: The study suggests that early exposure to acetaminophen may have negative effects on neurodevelopment in rat pups, even when antioxidants are used to prevent accumulation of the toxic metabolite NAPQI. Furthermore, the combination of acetaminophen with antioxidants led to increased rearing behavior in rats, indicating that oxidative stress mediators cannot entirely eliminate the effects of acetaminophen on neurodevelopment.
Review
Medicine, Legal
Deborah M. Proctor, Virunya Bhat, Mina Suh, Heidi Reichert, Xiaohui Jiang, Chad M. Thompson
Summary: The study reviewed the concentrations of hexavalent chromium in ambient air, which exceed residential exposure screening levels. However, based on margins of exposure, current environmental exposure to Cr(VI) is considered low risk.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Jared N. Gloria, John Yerxa, Samuel J. Kesseli, Robert P. Davis, Mariya L. Samoylova, Andrew S. Barbas, Matthew G. Hartwig
Summary: Lowering the temperature during ex vivo lung perfusion can reduce the production of inflammatory mediators and decrease graft injury after transplantation.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Aarushi Venkatakrishnan, Zoie E. Holzknecht, Rob Holzknecht, Dawn E. Bowles, Sanet H. Kotze, Jennifer L. Modliszewski, William Parker
Summary: Several factors in Western society, such as antibiotic use, chronic inflammation, and decreased dietary fiber, impact the gut microbiota. These changes lead to rapid Darwinian evolution in microorganisms, resulting in bacteria with potentially pathogenic properties.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Evolutionary Biology
Scott Sauer, Dylan Beinart, Sade M. B. Finn, Sereena L. Kumar, Qing Cheng, Shelley E. Hwang, William Parker, Gayathri R. Devi
Summary: The findings suggest that biota alteration may not be a significant factor in the high rate of breast cancer observed in Western societies.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)
Review
Evolutionary Biology
William Parker, Joshua T. Sarafian, Sherryl A. Broverman, Jon D. Laman
Summary: Suboptimal understanding of hygiene concepts is a persistent issue in health and medicine. Hygiene is crucial for preventing deadly pandemics, but can also lead to a loss of biodiversity and increased susceptibility to certain diseases. Personal hygiene practices and system-wide hygiene measures have different effects on immune function, and finding a balance between the benefits and drawbacks of hygiene is essential.
EVOLUTION MEDICINE AND PUBLIC HEALTH
(2021)
Article
Transplantation
Robert P. Davis, John Yerxa, Qimeng Gao, Jared Gloria, Uwe Scheuermann, Mingqing Song, Min Zhang, William Parker, Jaewoo Lee, Matthew G. Hartwig, Andrew S. Barbas
TRANSPLANTATION DIRECT
(2020)
Article
Psychology, Developmental
Cynthia Nevison, William Parker
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
(2020)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)