Article
Orthopedics
Maarten C. Koper, Brechtje Hesseling, Wim E. Tuinebreijer, Hans van der Linden, Nina M. C. Mathijssen
Summary: This study followed up 160 patients with primary large head MoM prostheses for 10 years. Results showed that female gender, cup inclination angles over 45 degrees, higher levels of cobalt, and chromium were associated with an increased risk of revision for ARMD. The safe upper limits for cobalt and chromium were determined to be 4.1 ppb and 4.2 ppb, respectively.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Multidisciplinary Sciences
Olli Lainiala, Mari Karsikas, Aleksi Reito, Antti Eskelinen
Summary: The study suggests that blood chromium is rarely elevated independently in MoM hip replacements, and its measurement could be omitted from follow-up protocols without decreasing the quality of follow-up.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Antongiulio Bruschetta, Michelangelo Palco, Domenico Fenga, Gabriele Giuca, Lukas A. Holzer, Angelo Alito, Giorgio Cacciola, Federico De Meo, Pietro Cavaliere
Summary: This study describes a series of patients with painful local adverse tissue reactions due to corrosion at the modular neck-body interface, and investigates the correlation between metallosis and infection. Retrospective analysis showed elevated cobalt and chromium levels, increased erythrocyte sedimentation rate and C-reactive protein, and adverse reactions to metal debris on magnetic resonance imaging.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Orthopedics
Harold I. Salmons, Daniel Karczewski, Cameron K. Ledford, Nicholas A. Bedard, Cody C. Wyles, Matthew P. Abdel
Summary: This study investigated the effect of femoral head length on the risk of revision and reoperation after cobalt chromium-on-highly crosslinked polyethylene THAs. The results showed that altering the femoral head length did not have a significant effect on outcomes, and surgeons should consider other factors such as hip stability and center of rotation when selecting femoral head lengths.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Orthopedics
Hannah Spece, Eric S. Ouellette, Olivia L. Jones, Daniel W. MacDonald, Nicolas S. Piuzzi, Gwo-Chin Lee, Michael A. Mont, Gregg R. Klein, Steven M. Kurtz
Summary: This study evaluated 56 retrieved dual mobility constructs, finding that the most common reasons for revision were infection, loosening, and instability/dislocation. The main polyethylene damage mechanisms included scratching, pitting, burnishing, and embedded debris, with no overall difference in damage found between primary and revision cases.
JOURNAL OF ARTHROPLASTY
(2021)
Review
Polymer Science
Liliana Savin, Tudor Pinteala, Dana Nicoleta Mihai, Dan Mihailescu, Smaranda Stefana Miu, Mihnea Theodor Sirbu, Bogdan Veliceasa, Dragos Cristian Popescu, Paul Dan Sirbu, Norin Forna
Summary: Total hip arthroplasty is a popular and effective surgical intervention for treating hip diseases. The success of the surgery depends on factors such as patient characteristics, surgical technique, and the quality of biomaterials used. Recent studies have assessed the benefits and drawbacks of different biomaterial and friction couples in total hip arthroplasty.
Article
Environmental Sciences
Bahaa Hemdan, Vijay Kumar Garlapati, Swati Sharma, Sudipa Bhadra, Shivani Maddirala, K. M. Varsha, Vineela Motru, Pranab Goswami, Surajbhan Sevda, Tejraj M. Aminabhavi
Summary: Metals in industrial effluents pose a significant threat to the global environment due to their high toxicity, but innovative technologies like bioelectrochemical systems show promise in sustainable metal recovery. These technologies offer a more energy-efficient and environmentally friendly solution compared to traditional physical and chemical methods.
ENVIRONMENTAL RESEARCH
(2022)
Article
Orthopedics
Toshiomi Abe, Takuya Otani, Tetsuo Hayama, Hideki Fujii, Yasuhiko Kawaguchi, Mitsuru Saito
Summary: This study examined the medium-term clinical and radiological outcomes of revision total hip arthroplasty (THA) using the S-ROM-A stem. The results showed that this surgical technique resulted in good medium-term outcomes, but attention should be paid to the potential risk of trunnionosis.
JOURNAL OF ARTHROPLASTY
(2022)
Article
Chemistry, Multidisciplinary
Mette Holm Hjorth, Inger Mechlenburg, Frederik Nicolai Foldager, Marianne Tjur, Maiken Stilling
Summary: The study compared muscle mass, power, step test asymmetry, and patient-reported outcomes between MoM THA/HRA and MoP THA, finding no significant differences in functional outcomes.
APPLIED SCIENCES-BASEL
(2022)
Article
Engineering, Biomedical
Therese Bormann, Laura Nebel, Ulrike Mueller, Phuong Thao Mai, Jens Gibmeier, Tobias Renkawitz, J. Philippe Kretzer
Summary: Corrosion at the modular taper junctions in total hip arthroplasty is clinically relevant. In vitro tribo-corrosion tests using FeCl3 and H2O2 can provide more severe and realistic testing conditions compared to pure saline or calf serum.
ACTA BIOMATERIALIA
(2022)
Review
Biochemistry & Molecular Biology
Joanna Izabela Lachowicz, Luigi Isaia Lecca, Federico Meloni, Marcello Campagna
Summary: An increasing number of pathologies are related to the imbalance of toxic and essential metal ions, affecting conditions like neurodegeneration and diabetes. Metal intoxication lacks characteristic symptoms, making diagnosis challenging. There have been recent advances in the treatment of metal-related diseases.
Review
Toxicology
Lin Liu, Lu Kong
Summary: Metal nanomaterials, with their potential applications, have raised concerns about their potential toxicity and carcinogenicity. Their ability to cause DNA damage and mutations may lead to genotoxicity and cancer, highlighting the importance of their rational use in modern industries and biomedicine.
JOURNAL OF APPLIED TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Arjunan Karuppaiah, Divakar Selvaraj, Mohan Sellappan, Arumugam Nagarajan, Dinesh Babu, Habibur Rahman, Thiagarajan Madheswaran, Bharadhan Bose, Tamilselvan Natrajan
Summary: Metallic nanoparticles (MNPs) have been widely used in clinical practice for diagnostic and therapeutic purposes, but their potential toxicity is a concern. Numerous research studies are being conducted to explore strategies to reduce the toxicity of MNPs, including modifying their size, dose, agglomeration, release, and excretion rates. In addition, managing the toxicity of MNPs can be achieved through purification, surface functionalization, synergistic effects, and targeted therapy approaches. These strategies can decrease the dose of MNPs without compromising their therapeutic benefits, thus reducing their toxicity.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Article
Orthopedics
Samir Meriem, Alexander Antoniadis, Michele Palazzuolo, Julien Wegrzyn
Summary: The use of dual mobility cup (DMC) in revision total hip arthroplasty (THA) for failed large head metal-on-metal (MoM) bearings provides a reliable option to prevent instability and ensure a stable acetabular reconstruction. However, dislocation remains a concern, particularly in cases with severe soft tissue damage related to adverse reaction to metal debris (ARMD).
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Materials Science, Biomaterials
Estefania Echeverri, Charlotte Skjoldebrand, Paul O'Callaghan, Anders Palmquist, Johan Kreuger, Gry Hulsart-Billstrom, Cecilia Persson
Summary: Silicon nitride (SiN) coatings with added iron (Fe) and carbon (C) have the potential to reduce metal ion release from metallic implants. This study investigated the effect of Fe and C on the dissolution rate of SiN coatings and their impact on the viability of microglia cells expected at the implant site. The results showed that Fe and C additives reduced ion release and did not compromise cell viability, suggesting their potential for increasing the lifetime and functionality of SiN-coated metallic implants.
BIOMATERIALS SCIENCE
(2023)