Representing Diversity in the Dish: Using Patient-Derived in Vitro Models to Recreate the Heterogeneity of Neurological Disease

Stem cell transplantation for Huntington’s diseases

(2018) Kyung-Ah Choi et al.   METHODS

iPS-derived neural progenitor cells from PPMS patients reveal defect in myelin injury response

(2017) Alexandra M. Nicaise et al.   EXPERIMENTAL NEUROLOGY

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

(2017) Jing Zhao et al.   HUMAN MOLECULAR GENETICS

Stem cells for ALS: An overview of possible therapeutic approaches

(2017) Joanna Czarzasta et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Generation of pure GABAergic neurons by transcription factor programming

(2017) Nan Yang et al.   NATURE METHODS

Neural stem cell therapy for neurodegenerative disorders: The role of neurotrophic support

(2017) Samuel E. Marsh et al.   NEUROCHEMISTRY INTERNATIONAL

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases

(2017) Hong Joo Kim et al.   NEURON

Mutant Huntingtin Disrupts the Nuclear Pore Complex

(2017) Jonathan C. Grima et al.   NEURON

The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders

(2017) Derek K. Smith et al.   PROGRESS IN NEUROBIOLOGY

Human induced pluripotent stem cells as a research tool in Alzheimer's disease

(2017) J. P. Robbins et al.   PSYCHOLOGICAL MEDICINE

PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

(2017) Audrey S. Dickey et al.   Science Translational Medicine

CRISPR/Cas9 and piggyBac-mediated footprint-free LRRK2-G2019S knock-in reveals neuronal complexity phenotypes and α-Synuclein modulation in dopaminergic neurons

(2017) Xiaobing Qing et al.   Stem Cell Research

Concise Review: The Use of Stem Cells for Understanding and Treating Huntington's Disease

(2017) Bronwen Connor   STEM CELLS

Aberrant iPSC-derived human astrocytes in Alzheimer's disease

(2017) V C Jones et al.   Cell Death & Disease

Two factor-based reprogramming of rodent and human fibroblasts into Schwann cells

(2017) Pietro Giuseppe Mazzara et al.   Nature Communications

Modeling the phenotype of spinal muscular atrophy by the direct conversion of human fibroblasts to motor neurons

(2017) Qi-Jie Zhang et al.   Oncotarget

Stem cell models of Alzheimer’s disease: progress and challenges

(2017) Charles Arber et al.   Alzheimers Research & Therapy

Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS

(2017) Claire E. Hall et al.   Cell Reports

Huntington’s Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits

(2017) Ryan G. Lim et al.   Cell Reports

Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms

(2017) Martin Madill et al.   Molecular Brain

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

Direct Conversion of Human Fibroblasts into Neural Progenitors Using Transcription Factors Enriched in Human ESC-Derived Neural Progenitors

(2017) Pei-Shan Hou et al.   Stem Cell Reports

Sporadic ALS Astrocytes Induce Neuronal Degeneration In Vivo

(2017) Kun Qian et al.   Stem Cell Reports

Directed Differentiation of Human Pluripotent Stem Cells to Microglia

(2017) Panagiotis Douvaras et al.   Stem Cell Reports

A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

(2017) Walther Haenseler et al.   Stem Cell Reports

Genetic Correction of SOD1 Mutant iPSCs Reveals ERK and JNK Activated AP1 as a Driver of Neurodegeneration in Amyotrophic Lateral Sclerosis

(2017) Akshay Bhinge et al.   Stem Cell Reports

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

(2017) Jonathan Arias-Fuenzalida et al.   Stem Cell Reports

Induced dopaminergic neurons: A new promise for Parkinson’s disease

(2017) Zhimin Xu et al.   Redox Biology

Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

(2017) Walther Haenseler et al.   Scientific Reports

Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism

(2016) Andreas Puschmann et al.   BRAIN

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Use of human stem cells in Huntington disease modeling and translational research

(2016) Monika M. Golas et al.   EXPERIMENTAL NEUROLOGY

How close are we to individualized medicine for Parkinson’s disease?

(2016) Hee Jin Kim et al.   Expert Review of Neurotherapeutics

Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin

(2016) Zixiao Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Directly converted patient-specific induced neurons mirror the neuropathology of FUS with disrupted nuclear localization in amyotrophic lateral sclerosis

(2016) Su Min Lim et al.   Molecular Neurodegeneration

3D culture models of Alzheimer’s disease: a road map to a “cure-in-a-dish”

(2016) Se Hoon Choi et al.   Molecular Neurodegeneration

Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons

(2016) Evgeny D. Nekrasov et al.   Molecular Neurodegeneration

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

(2016) Rodrigo Lopez-Gonzalez et al.   NEURON

Oligodendrocytes contribute to motor neuron death in ALS via SOD1-dependent mechanism

(2016) Laura Ferraiuolo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

α-Synuclein–induced lysosomal dysfunction occurs through disruptions in protein trafficking in human midbrain synucleinopathy models

(2016) Joseph R. Mazzulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes

(2016) Matthew R. Livesey et al.   STEM CELLS

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72 -ALS/FTD

(2016) Thomas Westergard et al.   Cell Reports

Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients

(2016) Meng-Lu Liu et al.   Cell Reports

Rapid Induction of Cerebral Organoids From Human Induced Pluripotent Stem Cells Using a Chemically Defined Hydrogel and Defined Cell Culture Medium

(2016) Beth A. Lindborg et al.   Stem Cells Translational Medicine

Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts

(2016) Christine J Huh et al.   eLife

How close are we to individualized medicine for Parkinson’s disease?

(2016) Hee Jin Kim et al.   Expert Review of Neurotherapeutics

Modeling Neurological Disease by Rapid Conversion of Human Urine Cells into Functional Neurons

(2016) Shu-Zhen Zhang et al.   Stem Cells International

Marked Differences in C9orf72 Methylation Status and Isoform Expression between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells

(2016) Yaara Cohen-Hadad et al.   Stem Cell Reports

ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

(2016) Hugo J.R. Fernandes et al.   Stem Cell Reports

Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury

(2016) Soya Kawabata et al.   Stem Cell Reports

Three Dimensional Human Neuro-Spheroid Model of Alzheimer’s Disease Based on Differentiated Induced Pluripotent Stem Cells

(2016) Han-Kyu Lee et al.   PLoS One

Self-Organizing 3D Human Neural Tissue Derived from Induced Pluripotent Stem Cells Recapitulate Alzheimer’s Disease Phenotypes

(2016) Waseem K. Raja et al.   PLoS One

Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease

(2016) Rachelle Balez et al.   Scientific Reports

Aberrant astrocytes impair vascular reactivity in Huntington disease

(2015) Han-Yun Hsiao et al.   ANNALS OF NEUROLOGY

Direct Conversion of Normal and Alzheimer’s Disease Human Fibroblasts into Neuronal Cells by Small Molecules

(2015) Wenxiang Hu et al.   Cell Stem Cell

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons

(2015) Xiang Li et al.   Cell Stem Cell

Huntington disease iPSCs show early molecular changes in intracellular signaling, the expression of oxidative stress proteins and the p53 pathway

(2015) Wojciech J. Szlachcic et al.   Disease Models & Mechanisms

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology

(2015) Ping-Wu Zhang et al.   GLIA

HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity

(2015) Virginia B. Mattis et al.   HUMAN MOLECULAR GENETICS

Elucidating the role of the A2Aadenosine receptor in neurodegeneration using neurons derived from Huntington's disease iPSCs

(2015) Feng-Lan Chiu et al.   HUMAN MOLECULAR GENETICS

MicroRNA-199a induces differentiation of induced pluripotent stem cells into endothelial cells by targeting sirtuin 1

(2015) ZHOUBIN LI et al.   Molecular Medicine Reports

Generation of functional human serotonergic neurons from fibroblasts

(2015) K C Vadodaria et al.   MOLECULAR PSYCHIATRY

Direct conversion of human fibroblasts to induced serotonergic neurons

(2015) Z Xu et al.   MOLECULAR PSYCHIATRY

The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

(2015) Ke Zhang et al.   NATURE

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

(2015) Brian D. Freibaum et al.   NATURE

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

(2015) Audrey S Dickey et al.   NATURE MEDICINE

MicroRNA-based conversion of human fibroblasts into striatal medium spiny neurons

(2015) Michelle Richner et al.   Nature Protocols

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Formation and characterisation of neuromuscular junctions between hiPSC derived motoneurons and myotubes

(2015) M. Demestre et al.   Stem Cell Research

Dysregulated expression of death, stress and mitochondrion related genes in the sciatic nerve of presymptomatic SOD1G93A mouse model of Amyotrophic Lateral Sclerosis

(2015) Chrystian J. Alves et al.   Frontiers in Cellular Neuroscience

The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells

(2015) Erin M. Boisvert et al.   Scientific Reports

Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and PNS Developmental Capacity

(2015) Jong-Hee Lee et al.   Cell Reports

Direct Conversion of Fibroblasts into Functional Astrocytes by Defined Transcription Factors

(2015) Massimiliano Caiazzo et al.   Stem Cell Reports

Generation of neural progenitor cells by chemical cocktails and hypoxia

(2014) Lin Cheng et al.   CELL RESEARCH

Inhibition of soluble tumor necrosis factor is therapeutic in Huntington's disease

(2014) Han-Yun Hsiao et al.   HUMAN MOLECULAR GENETICS

The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons

(2014) Christina R. Muratore et al.   HUMAN MOLECULAR GENETICS

Remote control of induced dopaminergic neurons in parkinsonian rats

(2014) Maria Teresa Dell’Anno et al.   JOURNAL OF CLINICAL INVESTIGATION

Stem cell derived basal forebrain cholinergic neurons from Alzheimer’s disease patients are more susceptible to cell death

(2014) Lishu Duan et al.   Molecular Neurodegeneration

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

Selective conversion of fibroblasts into peripheral sensory neurons

(2014) Joel W Blanchard et al.   NATURE NEUROSCIENCE

Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts

(2014) Brian J Wainger et al.   NATURE NEUROSCIENCE

Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

(2014) Zhaoming Su et al.   NEURON

Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death

(2014) Xinmei Wen et al.   NEURON

Generation of Human Striatal Neurons by MicroRNA-Dependent Direct Conversion of Fibroblasts

(2014) Matheus B. Victor et al.   NEURON

Characterization and Molecular Profiling of PSEN1 Familial Alzheimer's Disease iPSC-Derived Neural Progenitors

(2014) Andrew A. Sproul et al.   PLoS One

Direct Reprogramming of Huntington’s Disease Patient Fibroblasts into Neuron-Like Cells Leads to Abnormal Neurite Outgrowth, Increased Cell Death, and Aggregate Formation

(2014) Yanying Liu et al.   PLoS One

Activation of Neural Cell Fate Programs Toward Direct Conversion of Adult Human Fibroblasts into Tri-Potent Neural Progenitors Using OCT-4

(2014) Ryan R. Mitchell et al.   STEM CELLS AND DEVELOPMENT

Induced Pluripotent Stem Cells from Familial Alzheimer's Disease Patients Differentiate into Mature Neurons with Amyloidogenic Properties

(2014) Vasiliki Mahairaki et al.   STEM CELLS AND DEVELOPMENT

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons

(2014) Brian J. Wainger et al.   Cell Reports

Direct Neural Conversion from Human Fibroblasts Using Self-Regulating and Nonintegrating Viral Vectors

(2014) Shong Lau et al.   Cell Reports

Conversion of Fibroblasts to Neural Cells by p53 Depletion

(2014) Di Zhou et al.   Cell Reports

Efficient Generation of Myelinating Oligodendrocytes from Primary Progressive Multiple Sclerosis Patients by Induced Pluripotent Stem Cells

(2014) Panagiotis Douvaras et al.   Stem Cell Reports

Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

(2013) Sandra Almeida et al.   ACTA NEUROPATHOLOGICA

miR-196a Ameliorates Phenotypes of Huntington Disease in Cell, Transgenic Mouse, and Induced Pluripotent Stem Cell Models

(2013) Pei-Hsun Cheng et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A 3D Alzheimer's disease culture model and the induction of P21-activated kinase mediated sensing in iPSC derived neurons

(2013) Dawei Zhang et al.   BIOMATERIALS

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Direct Conversion of Adipocyte Progenitors into Functional Neurons

(2013) Yuanyuan Yang et al.   Cellular Reprogramming

A cellular model for sporadic ALS using patient-derived induced pluripotent stem cells

(2013) Matthew F. Burkhardt et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Generation of oligodendroglial cells by direct lineage conversion

(2013) Nan Yang et al.   NATURE BIOTECHNOLOGY

Transcription factor–mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells

(2013) Fadi J Najm et al.   NATURE BIOTECHNOLOGY

RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

(2013) Christopher J. Donnelly et al.   NEURON

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

(2013) Peter Reinhardt et al.   PLoS One

Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS

(2013) K. Meyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

(2013) A. Serio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration

(2013) C. Lagier-Tourenne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of induced neurons via direct conversion in vivo

(2013) O. Torper et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

(2013) D. Sareen et al.   Science Translational Medicine

Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions

(2013) Atossa Shaltouki et al.   STEM CELLS

Generation of Patient-Specific Induced Neuronal Cells Using a Direct Reprogramming Strategy

(2013) Pu Wang et al.   STEM CELLS AND DEVELOPMENT

Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons

(2013) Meng-Lu Liu et al.   Nature Communications

The Presenilin-1 ΔE9 Mutation Results in Reduced γ-Secretase Activity, but Not Total Loss of PS1 Function, in Isogenic Human Stem Cells

(2013) Grace Woodruff et al.   Cell Reports

Rapid Generation of Functional Dopaminergic Neurons From Human Induced Pluripotent Stem Cells Through a Single-Step Procedure Using Cell Lineage Transcription Factors

(2013) Ilda Theka et al.   Stem Cells Translational Medicine

Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-Repeat-Expansion-Associated Phenotypes

(2012) The HD iPSC Consortium   Cell Stem Cell

Genetic Correction of Huntington's Disease Phenotypes in Induced Pluripotent Stem Cells

(2012) Mahru C. An et al.   Cell Stem Cell

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells

(2012) Mason A. Israel et al.   NATURE

Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells

(2012) Ethan S Lippmann et al.   NATURE BIOTECHNOLOGY

Small molecules enable highly efficient neuronal conversion of human fibroblasts

(2012) Julia Ladewig et al.   NATURE METHODS

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

Induced Pluripotent Stem Cell Models of Progranulin-Deficient Frontotemporal Dementia Uncover Specific Reversible Neuronal Defects

(2012) Sandra Almeida et al.   Cell Reports

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

(2012) Tarja A Juopperi et al.   Molecular Brain

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells

(2011) Xinjian Liu et al.   CELL RESEARCH

Functional Integration of Dopaminergic Neurons Directly Converted from Mouse Fibroblasts

(2011) Jongpil Kim et al.   Cell Stem Cell

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Induced Neuronal Cells: How to Make and Define a Neuron

(2011) Nan Yang et al.   Cell Stem Cell

Direct Reprogramming of Adult Human Fibroblasts to Functional Neurons under Defined Conditions

(2011) Rajesh Ambasudhan et al.   Cell Stem Cell

Direct Lineage Conversion of Terminally Differentiated Hepatocytes to Functional Neurons

(2011) Samuele Marro et al.   Cell Stem Cell

Conversion of Mouse and Human Fibroblasts into Functional Spinal Motor Neurons

(2011) Esther Y. Son et al.   Cell Stem Cell

Differentiation of induced pluripotent stem cells into functional oligodendrocytes

(2011) Marcin Czepiel et al.   GLIA

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

Direct generation of functional dopaminergic neurons from mouse and human fibroblasts

(2011) Massimiliano Caiazzo et al.   NATURE

Induction of human neuronal cells by defined transcription factors

(2011) Zhiping P. Pang et al.   NATURE

Specification of transplantable astroglial subtypes from human pluripotent stem cells

(2011) Robert Krencik et al.   NATURE BIOTECHNOLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

Direct reprogramming of mouse fibroblasts to neural progenitors

(2011) J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct conversion of human fibroblasts to dopaminergic neurons

(2011) U. Pfisterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis

(2011) Bi Song et al.   Stem Cell Research

Efficient Differentiation of Human Embryonic and Induced Pluripotent Stem Cells into Functional Astrocytes

(2011) Luni Emdad et al.   STEM CELLS AND DEVELOPMENT

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Gingival Fibroblasts as a Promising Source of Induced Pluripotent Stem Cells

(2010) Hiroshi Egusa et al.   PLoS One

Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS

(2009) S. Karumbayaram et al.   Disease Models & Mechanisms

Comparison of efficiency of terminal differentiation of oligodendrocytes from induced pluripotent stem cells versus embryonic stem cells in vitro

(2009) Yasuhito Tokumoto et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Differentiation of human oligodendrocytes from pluripotent stem cells

(2009) Bao-Yang Hu et al.   Nature Protocols

Disease-Specific Induced Pluripotent Stem Cells

(2008) In-Hyun Park et al.   CELL

Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage

(2008) Y. Elkabetz et al.   GENES & DEVELOPMENT

Induced Pluripotent Stem Cells Generated from Patients with ALS Can Be Differentiated into Motor Neurons

(2008) J. T. Dimos et al.   SCIENCE