PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Cdk5-mediated mitochondrial fission: A key player in dopaminergic toxicity in Huntington's disease

(2015) Marta Cherubini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HDAC6 inhibition induces mitochondrial fusion, autophagic flux and reduces diffuse mutant huntingtin in striatal neurons

(2015) Pedro Guedes-Dias et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer’s disease through inhibition of inflammation

(2015) Tarja Malm et al.   Journal of Neuroinflammation

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

(2015) Audrey S Dickey et al.   NATURE MEDICINE

Nuclear Receptors, RXR, and the Big Bang

(2014) Ronald M. Evans et al.   CELL

PPARβ/δ attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells

(2014) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Preclinical research: Make mouse studies work

(2014) Steve Perrin   NATURE

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

(2014) Erin E. Watkin et al.   PLoS One

Ten-year Experience of Bexarotene Therapy for Cutaneous T-cell Lymphoma in Finland

(2013) L Väkevä et al.   ACTA DERMATO-VENEREOLOGICA

S-Nitrosylation of Dynamin-Related Protein 1 Mediates Mutant Huntingtin-Induced Mitochondrial Fragmentation and Neuronal Injury in Huntington's Disease

(2013) Florian Haun et al.   ANTIOXIDANTS & REDOX SIGNALING

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner

(2012) Magdalena Frank et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Metabolic Signatures Uncover Distinct Targets in Molecular Subsets of Diffuse Large B Cell Lymphoma

(2012) Pilar Caro et al.   CANCER CELL

A call for transparent reporting to optimize the predictive value of preclinical research

(2012) Story C. Landis et al.   NATURE

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Nuclear receptors as therapeutic targets for Alzheimer's disease

(2011) Shweta Mandrekar-Colucci et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

PKA/AKAP1 and PP2A/B 2 Regulate Neuronal Morphogenesis via Drp1 Phosphorylation and Mitochondrial Bioenergetics

(2011) A. S. Dickey et al.   JOURNAL OF NEUROSCIENCE

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Repeat expansion disease: progress and puzzles in disease pathogenesis

(2010) Albert R. La Spada et al.   NATURE REVIEWS GENETICS

Impaired PGC-1α function in muscle in Huntington's disease

(2009) Rajnish K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

Polyglutamine-Expanded Androgen Receptor Truncation Fragments Activate a Bax-Dependent Apoptotic Cascade Mediated by DP5/Hrk

(2009) J. E. Young et al.   JOURNAL OF NEUROSCIENCE

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nutrient Deprivation Induces Neuronal Autophagy and Implicates Reduced Insulin Signaling in Neuroprotective Autophagy Activation

(2008) Jessica E. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY