How close are we to individualized medicine for Parkinson’s disease?

Systematic Analysis of Candidate Genes for Alzheimer's Disease in a French, Genome-Wide Association Study

(2017) Geoffroy Laumet et al.   JOURNAL OF ALZHEIMERS DISEASE

Precision Medicine

(2016) M Pacanowski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

DRD and GRIN2B polymorphisms and their association with the development of impulse control behaviour among Malaysian Parkinson’s disease patients

(2015) Shahidee Zainal Abidin et al.   BMC Neurology

Polymorphism of the dopamine transporter type 1 gene modifies the treatment response in Parkinson’s disease

(2015) Caroline Moreau et al.   BRAIN

Advancing Pharmacogenomics as a Component of Precision Medicine: How, Where, and Who?

(2015) JA Johnson et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Neuroprotection in Parkinson's disease: a difficult challenge

(2015) Fabrizio Stocchi   LANCET NEUROLOGY

BDNF polymorphism associates with decline in set shifting in Parkinson's disease

(2015) Nicolien M. van der Kolk et al.   NEUROBIOLOGY OF AGING

Time to change the blind men and the elephant approach to Parkinson disease?

(2015) Brad A. Racette et al.   NEUROLOGY

Cognitive, Neuropsychiatric, and Motor Features Associated With Apolipoprotein E ∊4 Allele in a Sample of Bulgarian Patients With Late-Onset Parkinson’s Disease

(2014) Radka Pavlova et al.   American Journal of Alzheimers Disease and Other Dementias

Genetic impact on cognition and brain function in newly diagnosed Parkinson’s disease: ICICLE-PD study

(2014) Cristina Nombela et al.   BRAIN

Sequence Variants in SLC6A3, DRD2, and BDNF Genes and Time to Levodopa-Induced Dyskinesias in Parkinson’s Disease

(2014) Natalie Kaplan et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Impulse control disorder in patients with Parkinson's disease under dopamine agonist therapy: a multicentre study

(2014) P. J. Garcia-Ruiz et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Linking neuroscience with modern concepts of impulse control disorders in Parkinson's disease

(2014) T. Celeste Napier et al.   MOVEMENT DISORDERS

Clinical spectrum of impulse control disorders in Parkinson's disease

(2014) Daniel Weintraub et al.   MOVEMENT DISORDERS

The neurobiological basis of cognitive impairment in Parkinson's disease

(2014) Glenda M. Halliday et al.   MOVEMENT DISORDERS

GBA-associated Parkinson's disease: Reduced survival and more rapid progression in a prospective longitudinal study

(2014) Kathrin Brockmann et al.   MOVEMENT DISORDERS

BDNF G196A (Val66Met) polymorphism associated with cognitive impairment in Parkinson's disease

(2014) Monika Białecka et al.   NEUROSCIENCE LETTERS

Association of Catechol-O-Methyltransferase and monoamine oxidase B gene polymorphisms with motor complications in parkinson's disease in a Chinese population

(2014) Hongying Hao et al.   PARKINSONISM & RELATED DISORDERS

Catechol-O-methyltransferase Val158Met polymorphism: Modulation of wearing-off susceptibility in a Chinese cohort of Parkinson's disease

(2014) Hui Wu et al.   PARKINSONISM & RELATED DISORDERS

APOE,MAPT, andSNCAGenes and Cognitive Performance in Parkinson Disease

(2014) Ignacio F. Mata et al.   JAMA Neurology

Predicting Cognitive Decline in Parkinson’s Disease: Can We Ask the Genes?

(2014) Fabiola De Marchi et al.   Frontiers in Neurology

Glucocerebrosidase mutations influence the natural history of Parkinson’s disease in a community-based incident cohort

(2013) Sophie E. Winder-Rhodes et al.   BRAIN

No Association between Brain-Derived Neurotrophic Factor G196A Polymorphism and Clinical Features of Parkinson's Disease

(2013) Marina Svetel et al.   EUROPEAN NEUROLOGY

Original article Association of monoamine oxidase B and catechol-O-methyltransferase polymorphisms with sporadic Parkinson’s disease in an Iranian population

(2013) Anahita Torkaman-Boutorabi et al.   FOLIA NEUROPATHOLOGICA

Polymorphisms in the dopamine transporter gene are associated with visual hallucinations and levodopa equivalent dose in Brazilians with Parkinson's disease

(2013) Artur F Schumacher-Schuh et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Cry1 and Tef gene polymorphisms are associated with major depressive disorder in the Chinese population

(2013) Ping Hua et al.   JOURNAL OF AFFECTIVE DISORDERS

Screening for impulse control symptoms in patients with de novo Parkinson disease: A case-control study

(2013) D. Weintraub et al.   NEUROLOGY

Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies

(2013) Ariana P. Gatt et al.   NEUROSCIENCE LETTERS

Clinical and Biochemical Differences in Patients Having Parkinson Disease With vs WithoutGBAMutations

(2013) Lama M. Chahine et al.   JAMA Neurology

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Circadian and sleep disorders in Parkinson's disease

(2012) Aleksandar Videnovic et al.   EXPERIMENTAL NEUROLOGY

The six gaps in the search of neuroprotection for Parkinson’s disease

(2012) Alberto J Espay et al.   Expert Review of Neurotherapeutics

Serotonergic involvement in levodopa-induced dyskinesias in Parkinson’s disease

(2012) Perdita A. Cheshire et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment

(2012) Per Svenningsson et al.   LANCET NEUROLOGY

Association of Tef polymorphism with depression in Parkinson disease

(2012) Ping Hua et al.   MOVEMENT DISORDERS

Trial designs used to study neuroprotective therapy in Parkinson's disease

(2012) Anthony E. Lang et al.   MOVEMENT DISORDERS

Genetic influences on cognitive decline in Parkinson's disease

(2012) James F. Morley et al.   MOVEMENT DISORDERS

Impulse Control and Related Disorders in Parkinson’s Disease

(2012) Daniel Weintraub et al.   Neurodegenerative Diseases

Cognitive performance of GBA mutation carriers with early-onset PD: The CORE-PD study

(2012) R. N. Alcalay et al.   NEUROLOGY

DRD2 haplotype is associated with dyskinesia induced by levodopa therapy in Parkinson’s disease patients

(2012) Mariana Rieck et al.   PHARMACOGENOMICS

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Converging evidence implicates the dopamine D3 receptor gene in vulnerability to schizophrenia

(2011) Fuquan Zhang et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Therapies for dopaminergic-induced dyskinesias in parkinson disease

(2011) Mildred D. Gottwald et al.   ANNALS OF NEUROLOGY

Dementia Risk in Parkinson Disease

(2011) Núria Setó-Salvia et al.   ARCHIVES OF NEUROLOGY

Pharmacological treatment and the prospect of pharmacogenetics in Parkinson’s disease

(2011) K. Kalinderi et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Initial neuropsychological impairments in patients with the E46K mutation of the α-synuclein gene (PARK 1)

(2011) Johanne H. Somme et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Sleep disorders in Parkinson's disease: Many causes, few therapeutic options

(2011) Nico J. Diederich et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Catechol-O-methyltransferase Val158Met and the risk of dyskinesias in Parkinson's disease

(2011) Lonneke M.L. de Lau et al.   MOVEMENT DISORDERS

Disease-related and genetic correlates of psychotic symptoms in Parkinson's disease

(2011) Stewart A. Factor et al.   MOVEMENT DISORDERS

The motor phenotype of Parkinson's disease in relation to age at onset

(2011) Mirdhu M. Wickremaratchi et al.   MOVEMENT DISORDERS

DLB and PDD: a role for mutations in dementia and Parkinson disease genes?

(2011) Bram Meeus et al.   NEUROBIOLOGY OF AGING

GBA-associated PD presents with nonmotor characteristics

(2011) K. Brockmann et al.   NEUROLOGY

Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson’s disease

(2011) Jee-Young Lee et al.   PARKINSONISM & RELATED DISORDERS

Role of genetic polymorphisms of the dopaminergic system in Parkinson’s disease patients with impulse control disorders

(2011) Annamaria Vallelunga et al.   PARKINSONISM & RELATED DISORDERS

TrkB receptor controls striatal formation by regulating the number of newborn striatal neurons

(2011) M. Baydyuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain-derived neurotrophic factor G196A polymorphism and clinical features in Parkinson’s disease

(2010) L. Gao et al.   ACTA NEUROLOGICA SCANDINAVICA

The role of apolipoprotein E polymorphisms in levodopa-induced dyskinesia

(2010) I. Molchadski et al.   ACTA NEUROLOGICA SCANDINAVICA

Maladaptive plasticity of serotonin axon terminals in levodopa-induced dyskinesia

(2010) Daniella Rylander et al.   ANNALS OF NEUROLOGY

The COMT Val158Met polymorphism affects the response to entacapone in Parkinson's disease: A randomized crossover clinical trial

(2010) Jean-Christophe Corvol et al.   ANNALS OF NEUROLOGY

Impulse Control Disorders in Parkinson Disease

(2010) Daniel Weintraub et al.   ARCHIVES OF NEUROLOGY

Relationships between age and late progression of Parkinson's disease: a clinico-pathological study

(2010) P. A. Kempster et al.   BRAIN

SIRT1 gene is associated with major depressive disorder in the Japanese population

(2010) Taro Kishi et al.   JOURNAL OF AFFECTIVE DISORDERS

Two Parkinson's disease patients with α-synuclein gene duplication and rapid cognitive decline

(2010) Chae Won Shin et al.   MOVEMENT DISORDERS

Catechol-O-methyltransferase val158met and cognitive function in Parkinson's disease

(2010) Jeroen Hoogland et al.   MOVEMENT DISORDERS

Differential genetic susceptibility in diphasic and peak-dose dyskinesias in Parkinson's disease

(2010) Jee-Young Lee et al.   MOVEMENT DISORDERS

Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder

(2010) Virginia Soria et al.   NEUROPSYCHOPHARMACOLOGY

The Path to Personalized Medicine

(2010) Margaret A. Hamburg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apolipoprotein E epsilon 4 allele is not associated with age at onset or MMSE of Parkinson’s disease in a Korean study

(2010) Hye Guk Ryu et al.   PARKINSONISM & RELATED DISORDERS

CRY2 Is Associated with Depression

(2010) Catharina Lavebratt et al.   PLoS One

Genetics of dopamine receptors and drug addiction: a comprehensive review

(2009) Bernard Le Foll et al.   BEHAVIOURAL PHARMACOLOGY

Haplotype frequencies at the DRD2 locus in populations of the East European Plain

(2009) Olga V Flegontova et al.   BMC GENETICS

The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort

(2009) Caroline H. Williams-Gray et al.   BRAIN

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson’s disease patients

(2009) Ying-Zi Liu et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

BDNF Val66Met polymorphism is associated with cognitive impairment in Italian patients with Parkinson’s disease

(2009) F. R. Guerini et al.   EUROPEAN JOURNAL OF NEUROLOGY

APOE Alleles in Parkinson Disease and Their Relationship to Cognitive Decline: A Population-based, Longitudinal Study

(2009) Martin Wilhelm Kurz et al.   JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY

Apolipoprotein E genotype as a risk factor for susceptibility to and dementia in Parkinson’s Disease

(2009) C. H. Williams-Gray et al.   JOURNAL OF NEUROLOGY

Motor complications in patients form the German Competence Network on Parkinson's disease and theDRD3 Ser9Glypolymorphism

(2009) Sebastian Paus et al.   MOVEMENT DISORDERS

Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson's disease

(2009) Jee-Young Lee et al.   MOVEMENT DISORDERS

No association between polymorphism of serotonin transporter gene and depression in Parkinson's disease in Chinese

(2009) Jing-Lin Zhang et al.   NEUROSCIENCE LETTERS

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association between the dose of dopaminergic medication and the behavioral disturbances in Parkinson disease

(2009) Jee-Young Lee et al.   PARKINSONISM & RELATED DISORDERS

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Targets for neuroprotection in Parkinson's disease

(2008) Talene A. Yacoubian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Pharmacogenetics and the serotonin transporter in late-life depression

(2008) Philip Gerretsen et al.   Expert Opinion on Drug Metabolism & Toxicology

BDNF val66met influences time to onset of levodopa induced dyskinesia in Parkinson's disease

(2008) T Foltynie et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genetic polymorphism of Angiotensin-Converting Enzyme is not associated with the development of Parkinson's disease and of l-dopa-induced adverse effects

(2008) Esterina Pascale et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

TheDRD2 TaqIA polymorphism and demand of dopaminergic medication in Parkinson's disease

(2008) Sebastian Paus et al.   MOVEMENT DISORDERS

The Sydney multicenter study of Parkinson's disease: The inevitability of dementia at 20 years

(2008) Mariese A. Hely et al.   MOVEMENT DISORDERS

Serotonin and dopamine transporter genes do not influence depression in Parkinson's disease

(2008) Nadeeka N.W. Dissanayaka et al.   MOVEMENT DISORDERS

Lack of association of APOE and tau polymorphisms with dementia in Parkinson’s disease

(2008) Mario Ezquerra et al.   NEUROSCIENCE LETTERS

The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinsonʼs disease, levodopa treatment response, and complications

(2008) Monika Bialecka et al.   Pharmacogenetics and Genomics

Variation in dopamine genes influences responsivity of the human reward system

(2008) J.-C. Dreher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-synuclein promoter haplotypes and dementia in Parkinson's Disease

(2007) E.V. De Marco et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

The relationship between impulsivity and impulse control disorders in Parkinson's disease

(2007) Ioannis U. Isaias et al.   MOVEMENT DISORDERS

Predictors of impulsivity and reward seeking behavior with dopamine agonists

(2007) William G. Ondo et al.   PARKINSONISM & RELATED DISORDERS