Human induced pluripotent stem cells as a research tool in Alzheimer's disease

Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells

(2017) Yuchen Qi et al.   NATURE BIOTECHNOLOGY

Efficient introduction of specific homozygous and heterozygous mutations using CRISPR/Cas9

(2016) Dominik Paquet et al.   NATURE

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients withMAPTmutations

(2015) Mariangela Iovino et al.   BRAIN

Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects

(2015) Jerome Mertens et al.   Cell Stem Cell

Creating Patient-Specific Neural Cells for the In Vitro Study of Brain Disorders

(2015) Kristen J. Brennand et al.   Stem Cell Reports

Human-induced pluripotent stem cells: potential for neurodegenerative diseases

(2014) C. A. Ross et al.   HUMAN MOLECULAR GENETICS

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

The aging signature: a hallmark of induced pluripotent stem cells?

(2013) Leili Rohani et al.   AGING CELL

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

(2013) Takayuki Kondo et al.   Cell Stem Cell

Genome editing of human pluripotent stem cells to generate human cellular disease models

(2013) K. Musunuru   Disease Models & Mechanisms

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

The utility of patient specific induced pluripotent stem cells for the modelling of Autistic Spectrum Disorders

(2013) Graham Cocks et al.   PSYCHOPHARMACOLOGY

APP Processing in Human Pluripotent Stem Cell-Derived Neurons Is Resistant to NSAID-Based γ-Secretase Modulation

(2013) Jerome Mertens et al.   Stem Cell Reports

Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses

(2012) Yichen Shi et al.   NATURE NEUROSCIENCE

Prevention of β-amyloid induced toxicity in human iPS cell-derived neurons by inhibition of Cyclin-dependent kinases and associated cell cycle events

(2012) Xiaohong Xu et al.   Stem Cell Research

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Modeling familial Alzheimer's disease with induced pluripotent stem cells

(2011) Takuya Yagi et al.   HUMAN MOLECULAR GENETICS

Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease

(2011) Naoki Yahata et al.   PLoS One

An improved method for generating consistent soluble amyloid-beta oligomer preparations for in vitro neurotoxicity studies

(2010) Deborah A. Ryan et al.   JOURNAL OF NEUROSCIENCE METHODS

Amyloid β-Protein Assembly and Alzheimer Disease

(2008) Robin Roychaudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removing Obstacles in Neuroscience Drug Discovery: The Future Path for Animal Models

(2008) Athina Markou et al.   NEUROPSYCHOPHARMACOLOGY