Emerging Players at the Intersection of Chondrocyte Loss of Maturational Arrest, Oxidative Stress, Senescence and Low-Grade Inflammation in Osteoarthritis

Protective effects of mitochondria-targeted antioxidants and statins on cholesterol-induced osteoarthritis

(2017) Saba Farnaghi et al.   FASEB JOURNAL

The nuclear factor-erythroid 2-related factor/heme oxygenase-1 axis is critical for the inflammatory features of type 2 diabetes–associated osteoarthritis

(2017) Carlos Vaamonde-Garcia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemokines and inflammation in osteoarthritis: Insights from patients and animal models

(2017) Carla R. Scanzello   JOURNAL OF ORTHOPAEDIC RESEARCH

Hyperlipidemic microenvironment conditionates damage mechanisms in human chondrocytes by oxidative stress

(2017) Daniel Medina-Luna et al.   Lipids in Health and Disease

Increased expression of damage-associated molecular patterns (DAMPs) in osteoarthritis of human knee joint compared to hip joint

(2017) John H. Rosenberg et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Damage-associated molecular patterns in the pathogenesis of osteoarthritis: potentially novel therapeutic targets

(2017) John H. Rosenberg et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

The role of metabolism in the pathogenesis of osteoarthritis

(2017) Ali Mobasheri et al.   Nature Reviews Rheumatology

Hydroxytyrosol modulates the levels of microRNA-9 and its target sirtuin-1 thereby counteracting oxidative stress-induced chondrocyte death

(2017) S. D'Adamo et al.   OSTEOARTHRITIS AND CARTILAGE

Chondroprotective activity of N-acetyl phenylalanine glucosamine derivative on knee joint structure and inflammation in a murine model of osteoarthritis

(2017) F. Veronesi et al.   OSTEOARTHRITIS AND CARTILAGE

CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy

(2017) J. Miotla Zarebska et al.   OSTEOARTHRITIS AND CARTILAGE

Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules

(2017) T.V. Stabler et al.   OSTEOARTHRITIS AND CARTILAGE

Compromised autophagy precedes meniscus degeneration and cartilage damage in mice

(2017) J.K. Meckes et al.   OSTEOARTHRITIS AND CARTILAGE

Knee osteoarthritis has doubled in prevalence since the mid-20th century

(2017) Ian J. Wallace et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dietary Fat Intake and Radiographic Progression of Knee Osteoarthritis: Data From the Osteoarthritis Initiative

(2017) Bing Lu et al.   ARTHRITIS CARE & RESEARCH

Characterisation of a divergent progenitor cell sub-populations in human osteoarthritic cartilage: the role of telomere erosion and replicative senescence

(2017) Christopher R. Fellows et al.   Scientific Reports

Innate Immune Responses and Osteoarthritis

(2017) Evangelia Kalaitzoglou et al.   Current Rheumatology Reports

Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor

(2017) Meredith A. Rowe et al.   Arthritis & Rheumatology

Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice

(2017) Chia-Lung Wu et al.   Arthritis & Rheumatology

T Cells in Osteoarthritis: Alterations and Beyond

(2017) Yu-sheng Li et al.   Frontiers in Immunology

Discovery of circulating proteins associated to knee radiographic osteoarthritis

(2017) Lucía Lourido et al.   Scientific Reports

Saturated fatty acids induce development of both metabolic syndrome and osteoarthritis in rats

(2017) Sunderajhan Sekar et al.   Scientific Reports

CCL2/CCR2, but not CCL5/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis

(2016) Harini Raghu et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitochondrial DNA haplogroups influence the risk of incident knee osteoarthritis in OAI and CHECK cohorts. A meta-analysis and functional study

(2016) Mercedes Fernández-Moreno et al.   ANNALS OF THE RHEUMATIC DISEASES

Hydroxytyrosol prevents chondrocyte death under oxidative stress by inducing autophagy through sirtuin 1-dependent and -independent mechanisms

(2016) Silvia Cetrullo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

ROS/oxidative stress signaling in osteoarthritis

(2016) Panagiotis Lepetsos et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Therapeutic potential of NADPH oxidase 1/4 inhibitors

(2016) G Teixeira et al.   BRITISH JOURNAL OF PHARMACOLOGY

Roles of Cell Cyle Regulators Cyclin D1, CDK4, and p53 in Knee Osteoarthritis

(2016) Xiongbai Zhu et al.   Genetic Testing and Molecular Biomarkers

Chaperonin 60 regulation of SOX9 ubiquitination mitigates the development of knee osteoarthritis

(2016) Jih-Yang Ko et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

(2016) Ming Xu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

DNA Damage Detection by 53BP1: Relationship to Species Longevity

(2016) Eleonora Croco et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Genetic instability and aging under the scrutiny of comparative biology: a meta-analysis of spontaneous micronuclei frequency

(2016) Eleonora Croco et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Sirt1 and the Mitochondria

(2016)   MOLECULES AND CELLS

The danger from within: alarmins in arthritis

(2016) Meriam Nefla et al.   Nature Reviews Rheumatology

Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

(2016) Subrata Kumar Biswas   Oxidative Medicine and Cellular Longevity

The Overexpression of NALP3 Inflammasome in Knee Osteoarthritis Is Associated with Synovial Membrane Prolidase and NADPH Oxidase 2

(2016) Denise Clavijo-Cornejo et al.   Oxidative Medicine and Cellular Longevity

The expression of SIRT1 in articular cartilage of patients with knee osteoarthritis and its correlation with disease severity

(2016) Yusheng Li et al.   Journal of Orthopaedic Surgery and Research

Review: Metabolic Regulation of Inflammation in Osteoarthritis

(2016) Francis Berenbaum et al.   Arthritis & Rheumatology

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis

(2015) R F Schelbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Synovial Fluid HMGB-1 Levels are Associated with Osteoarthritis Severity

(2015) Xueru Ke et al.   Clinical Laboratory

mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management

(2015) Silvia Cetrullo et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Leptin in osteoarthritis: Focus on articular cartilage and chondrocytes

(2015) Morena Scotece et al.   LIFE SCIENCES

Mitochondrial DNA maintenance: an appraisal

(2015) Alexander T. Akhmedov et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction

(2015) Johnathan Labbadia et al.   MOLECULAR CELL

Does lipopolysaccharide-mediated inflammation have a role in OA?

(2015) Zeyu Huang et al.   Nature Reviews Rheumatology

Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model

(2015) K.H. Collins et al.   OSTEOARTHRITIS AND CARTILAGE

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis

(2015) M.D. Gardiner et al.   OSTEOARTHRITIS AND CARTILAGE

The adverse effects of diabetes on osteoarthritis: update on clinical evidence and molecular mechanisms

(2015) K.B. King et al.   OSTEOARTHRITIS AND CARTILAGE

Inflammation in joint injury and post-traumatic osteoarthritis

(2015) J. Lieberthal et al.   OSTEOARTHRITIS AND CARTILAGE

Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

(2015) Serena Guidotti et al.   PLoS One

MicroRNA-33a regulates cholesterol synthesis and cholesterol efflux-related genes in osteoarthritic chondrocytes

(2015) Fotini Kostopoulou et al.   ARTHRITIS RESEARCH & THERAPY

Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll-like Receptor 4

(2015) Rachel E. Miller et al.   Arthritis & Rheumatology

Reduction in Disease Progression by Inhibition of Transforming Growth Factor α-CCL2 Signaling in Experimental Posttraumatic Osteoarthritis

(2015) C. Thomas G. Appleton et al.   Arthritis & Rheumatology

Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes

(2015) Paloma López de Figueroa et al.   Arthritis & Rheumatology

Mitochondrial Biogenesis Is Impaired in Osteoarthritis Chondrocytes but Reversible via Peroxisome Proliferator-Activated Receptor γ Coactivator 1α

(2015) Yun Wang et al.   Arthritis & Rheumatology

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Serum and synovial fluid chemokine ligand 2/monocyte chemoattractant protein 1 concentrations correlates with symptomatic severity in patients with knee osteoarthritis

(2015) Liang Li et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Genomic Analysis and Differential Expression of HMG and S100A Family in Human Arthritis: Upregulated Expression of Chemokines, IL-8 and Nitric Oxide by HMGB1

(2014) Ashok R. Amin et al.   DNA AND CELL BIOLOGY

PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages

(2014) Ying-Ju Chen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Peroxisome proliferator-activated receptor gamma in osteoarthritis

(2014) Hassan Fahmi et al.   Modern Rheumatology

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Human Osteoarthritic Cartilage Shows Reduced In Vivo Expression of IL-4, a Chondroprotective Cytokine that Differentially Modulates IL-1β-Stimulated Production of Chemokines and Matrix-Degrading Enzymes In Vitro

(2014) Elisa Assirelli et al.   PLoS One

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

(2014) Gary J. Litherland et al.   Arthritis & Rheumatology

Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes

(2014) Miriam T. Jackson et al.   Arthritis & Rheumatology

Palmitate Has Proapoptotic and Proinflammatory Effects on Articular Cartilage and Synergizes With Interleukin-1

(2014) Oscar Alvarez-Garcia et al.   Arthritis & Rheumatology

Cross-sectional and longitudinal associations between circulating leptin and knee cartilage thickness in older adults

(2013) Oliver P Stannus et al.   ANNALS OF THE RHEUMATIC DISEASES

Hsp90 Inhibition Protects Against Biomechanically Induced Osteoarthritis in Rats

(2013) Michiel Siebelt et al.   ARTHRITIS AND RHEUMATISM

Correlation between senescence-associated beta-galactosidase expression in articular cartilage and disease severity of patients with knee osteoarthritis

(2013) Shu-Guang Gao et al.   International Journal of Rheumatic Diseases

Sirt1-deficient mice exhibit an altered cartilage phenotype

(2013) Odile Gabay et al.   JOINT BONE SPINE

The relationship between ultra-short telomeres, aging of articular cartilage and the development of human hip osteoarthritis

(2013) M. Harbo et al.   MECHANISMS OF AGEING AND DEVELOPMENT

IKKα/CHUK Regulates Extracellular Matrix Remodeling Independent of Its Kinase Activity to Facilitate Articular Chondrocyte Differentiation

(2013) Eleonora Olivotto et al.   PLoS One

Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice

(2012) Odile Gabay et al.   ANNALS OF THE RHEUMATIC DISEASES

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in Osteoarthritis

(2012) Longhuo Wu et al.   CURRENT PHARMACEUTICAL DESIGN

GSK3 inactivation is involved in mitochondrial complex IV defect in transforming growth factor (TGF) β1-induced senescence

(2012) Hae-Ok Byun et al.   EXPERIMENTAL CELL RESEARCH

Association betweenCCL2haplotypes and knee osteoarthritis

(2012) S. L. Hulin-Curtis et al.   International Journal of Immunogenetics

Circulating miRNA Profiles in Patients with Metabolic Syndrome

(2012) Dwi Setyowati Karolina et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dietary polyphenols and mechanisms of osteoarthritis

(2012) Chwan-Li Shen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Macro view of microRNA function in osteoarthritis

(2012) Shigeru Miyaki et al.   Nature Reviews Rheumatology

DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes

(2012) J. Rose et al.   OSTEOARTHRITIS AND CARTILAGE

Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review

(2012) B.J.E. de Lange-Brokaar et al.   OSTEOARTHRITIS AND CARTILAGE

Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis

(2012) Fotini Kostopoulou et al.   PLoS One

Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4 signaling pathway

(2012) Fangyuan Wei et al.   ARTHRITIS RESEARCH & THERAPY

(n-3) Fatty Acids Alleviate Adipose Tissue Inflammation and Insulin Resistance: Mechanistic Insights

(2012) Nishan S. Kalupahana et al.   Advances in Nutrition

Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to proinflammatory cytokines interleukin-1β and tumor necrosis factor α

(2011) Robert Terkeltaub et al.   ARTHRITIS AND RHEUMATISM

Is Monocyte Chemotactic Protein 1 Elevated in Aseptic Loosening of TKA?: A Pilot Study

(2011) Vinod Dasa et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Obesity short-circuits stemness gene network in human adipose multipotent stem cells

(2011) Mar Roldan et al.   FASEB JOURNAL

AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan

(2011) Antero Salminen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts

(2011) Heidi Wähämaa et al.   ARTHRITIS RESEARCH & THERAPY

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

Senescent vs. non-senescent cells in the human annulus in vivo: Cell harvest with laser capture microdissection and gene expression studies with microarray analysis

(2010) Helen E Gruber et al.   BMC BIOTECHNOLOGY

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Role of transglutaminase 2 in apoptosis induced by hydrogen peroxide in human chondrocytes

(2010) Ilkyu Han et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

Analysis of early changes in the articular cartilage transcriptisome in the rat meniscal tear model of osteoarthritis: pathway comparisons with the rat anterior cruciate transection model and with human osteoarthritic cartilage

(2010) T. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

IKKα and IKKβ Each Function to Regulate NF-κB Activation in the TNF-Induced/Canonical Pathway

(2010) Mazhar Adli et al.   PLoS One

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Differential expression of αB-crystallin and evidence of its role as a mediator of matrix gene expression in osteoarthritis

(2009) Stijn Lambrecht et al.   ARTHRITIS AND RHEUMATISM

Knee osteoarthritis in obese women with cardiometabolic clustering

(2009) Maryfran Sowers et al.   ARTHRITIS AND RHEUMATISM

An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging

(2009) Monica Fuente et al.   CURRENT PHARMACEUTICAL DESIGN

Significant correlation of species longevity with DNA double strand break recognition but not with telomere length

(2009) Antonello Lorenzini et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Proteome characterization of human articular chondrocytes leads to novel insights in the function of small heat-shock proteins in chondrocyte homeostasis

(2009) S. Lambrecht et al.   OSTEOARTHRITIS AND CARTILAGE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Mitochondrial DNA haplogroups: Role in the prevalence and severity of knee osteoarthritis

(2008) Ignacio Rego-Pérez et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

Osteoarthritis in the context of ageing and evolution

(2007) Peter M. van der Kraan et al.   AGEING RESEARCH REVIEWS