Lithium Chloride Dependent Glycogen Synthase Kinase 3 Inactivation Links Oxidative DNA Damage, Hypertrophy and Senescence in Human Articular Chondrocytes and Reproduces Chondrocyte Phenotype of Obese Osteoarthritis Patients

Recent developments in the use of γ -H2AX as a quantitative DNA double-strand break biomarker

(2016) Christophe E. Redon et al.   Aging-US

p16INK4a and its regulator miR-24 link senescence and chondrocyte terminal differentiation-associated matrix remodeling in osteoarthritis

(2014) Didier Philipot et al.   ARTHRITIS RESEARCH & THERAPY

Link between PI3K/AKT/PTEN Pathway and NOX Protein in Diseases

(2014) Atsuko Nakanishi   Aging and Disease

Glycogen Synthase Kinase 3 Inhibition Stimulates Human Cartilage Destruction and Exacerbates Murine Osteoarthritis

(2014) Gary J. Litherland et al.   Arthritis & Rheumatology

Adipose-Derived Mesenchymal Stem Cells Exert Antiinflammatory Effects on Chondrocytes and Synoviocytes From Osteoarthritis Patients Through Prostaglandin E2

(2013) Cristina Manferdini et al.   ARTHRITIS AND RHEUMATISM

To Wnt or not to Wnt: the bone and joint health dilemma

(2013) Rik J. Lories et al.   Nature Reviews Rheumatology

Association between cartilage and bone biomarkers and incidence of radiographic knee osteoarthritis (RKOA) in UK females: a prospective study

(2013) O. Blumenfeld et al.   OSTEOARTHRITIS AND CARTILAGE

Enhanced Osteoblastogenesis of Adipose-Derived Stem Cells on Spermine Delivery via β-Catenin Activation

(2013) Serena Guidotti et al.   STEM CELLS AND DEVELOPMENT

Regulation of oxidative DNA damage repair: The adenine:8-oxo-guanine problem

(2012) Enni Markkanen et al.   CELL CYCLE

GSK-3α and GSK-3β Proteins Are Involved in Early Stages of Chondrocyte Differentiation with Functional Redundancy through RelA Protein Phosphorylation

(2012) Shozo Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes

(2012) J. Rose et al.   OSTEOARTHRITIS AND CARTILAGE

Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: a 3-year follow-up of the ROAD study

(2012) N. Yoshimura et al.   OSTEOARTHRITIS AND CARTILAGE

Growth Hormone Improves Growth Retardation Induced by Rapamycin without Blocking Its Antiproliferative and Antiangiogenic Effects on Rat Growth Plate

(2012) Óscar Álvarez-García et al.   PLoS One

Mitochondrial ROS production under cellular stress: comparison of different detection methods

(2011) Andrey V. Kuznetsov et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Molecular Players at the Intersection of Obesity and Osteoarthritis

(2011) M. Luisa Bonet et al.   CURRENT DRUG TARGETS

Aging and osteoarthritis

(2011) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Deletion of Glycogen Synthase Kinase-3β in Cartilage Results in Up-Regulation of Glycogen Synthase Kinase-3α Protein Expression

(2011) J. R. Gillespie et al.   ENDOCRINOLOGY

The 90-kDa Heat-shock Protein (Hsp90)-binding Immunophilin FKBP51 Is a Mitochondrial Protein That Translocates to the Nucleus to Protect Cells against Oxidative Stress

(2011) Luciana I. Gallo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Senescence of chondrocytes in aging articular cartilage: GADD45β mediates p21 expression in association with C/EBPβ in senescence-accelerated mice

(2011) Hirofumi Shimada et al.   PATHOLOGY RESEARCH AND PRACTICE

Matrix metalloproteinase 13 loss associated with impaired extracellular matrix remodeling disrupts chondrocyte differentiation by concerted effects on multiple regulatory factors

(2010) Rosa Maria Borzí et al.   ARTHRITIS AND RHEUMATISM

Why is osteoarthritis an age-related disease?

(2010) A. Shane Anderson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

GADD45β EnhancesCol10a1Transcription via the MTK1/MKK3/6/p38 Axis and Activation of C/EBPβ-TAD4 in Terminally Differentiating Chondrocytes

(2010) Kaneyuki Tsuchimochi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of the development of human monocyte-derived dendritic cells by lithium chloride

(2010) Ko-Jiunn Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders

(2010) Chi-Tso Chiu et al.   PHARMACOLOGY & THERAPEUTICS

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway

(2010) Wang Hui et al.   RHEUMATOLOGY

Smurf2 induces degradation of GSK-3β and upregulates β-catenin in chondrocytes: A potential mechanism for Smurf2-induced degeneration of articular cartilage

(2009) Qiuqian Wu et al.   EXPERIMENTAL CELL RESEARCH

Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks

(2009) M.P. Svetlova et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation

(2008) Yong-Hak Seo et al.   AGING CELL

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice

(2008) Qiuqian Wu et al.   ARTHRITIS AND RHEUMATISM

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Osteoarthritis in the context of ageing and evolution

(2007) Peter M. van der Kraan et al.   AGEING RESEARCH REVIEWS