Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model
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Title
Mitochondrial DNA Activates the NLRP3 Inflammasome and Predisposes to Type 1 Diabetes in Murine Model
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2017-02-27
DOI
10.3389/fimmu.2017.00164
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Note: Only part of the references are listed.- Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus
- (2016) Simone Caielli et al. JOURNAL OF EXPERIMENTAL MEDICINE
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- (2015) Prabhakaran Kumar et al. CYTOKINE
- Mast cells control insulitis and increase Treg cells to confer protection against STZ-induced type 1 diabetes in mice
- (2015) Daniela Carlos et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets
- (2015) Changyun Hu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3
- (2015) Reiner K. W. Mailer et al. Scientific Reports
- Mechanisms and Functions of Inflammasomes
- (2014) Mohamed Lamkanfi et al. CELL
- Myeloid-derived suppressor cells are increased in frequency but not maximally suppressive in peripheral blood of Type 1 Diabetes Mellitus patients
- (2014) Fatima Whitfield-Larry et al. CLINICAL IMMUNOLOGY
- The Pathogenesis and Natural History of Type 1 Diabetes
- (2013) M. A. Atkinson Cold Spring Harbor Perspectives in Medicine
- Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial
- (2013) Stephen E Gitelman et al. Lancet Diabetes & Endocrinology
- Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial
- (2012) K. C. Herold et al. DIABETOLOGIA
- Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis
- (2012) Kenichi Shimada et al. IMMUNITY
- Dynamic changes of the Th17/Tc17 and regulatory T cell populations interfere in the experimental autoimmune diabetes pathogenesis
- (2012) Juliana Navarro Ueda Yaochite et al. IMMUNOBIOLOGY
- Tc17 CD8+ T Cells Potentiate Th1-Mediated Autoimmune Diabetes in a Mouse Model
- (2012) A. Saxena et al. JOURNAL OF IMMUNOLOGY
- Cutting Edge: Mast Cells Critically Augment Myeloid-Derived Suppressor Cell Activity
- (2012) S. J. Saleem et al. JOURNAL OF IMMUNOLOGY
- Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy
- (2011) Sridevi Devaraj et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Anti-FcεR1 antibody injections activate basophils and mast cells and delay Type 1 diabetes onset in NOD mice
- (2011) Marc P. Hübner et al. CLINICAL IMMUNOLOGY
- Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens
- (2011) M. Lamkanfi et al. JOURNAL OF IMMUNOLOGY
- Caspase-1-Processed Cytokines IL-1 and IL-18 Promote IL-17 Production by and CD4 T Cells That Mediate Autoimmunity
- (2011) S. J. Lalor et al. JOURNAL OF IMMUNOLOGY
- The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
- (2011) Bolormaa Vandanmagsar et al. NATURE MEDICINE
- Two SNPs inNLRP3gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil
- (2010) A. Pontillo et al. AUTOIMMUNITY
- Th17 and Regulatory T Cells in Mediating and Restraining Inflammation
- (2010) Dan R. Littman et al. CELL
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- (2010) Ilaria Marigo et al. IMMUNITY
- NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses
- (2010) D. Gris et al. JOURNAL OF IMMUNOLOGY
- Characterization of Cytokine-Induced Myeloid-Derived Suppressor Cells from Normal Human Peripheral Blood Mononuclear Cells
- (2010) M. G. Lechner et al. JOURNAL OF IMMUNOLOGY
- Circulating mitochondrial DAMPs cause inflammatory responses to injury
- (2010) Qin Zhang et al. NATURE
- A Method for Generation of Bone Marrow-Derived Macrophages from Cryopreserved Mouse Bone Marrow Cells
- (2010) Fernanda M. Marim et al. PLoS One
- Mechanisms Underlying Lineage Commitment and Plasticity of Helper CD4+ T Cells
- (2010) J. J. O'Shea et al. SCIENCE
- The Inflammasomes: Guardians of the Body
- (2009) Fabio Martinon et al. Annual Review of Immunology
- Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation
- (2009) Abhishek D. Garg et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice
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- (2009) Yeonseok Chung et al. IMMUNITY
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- (2009) Caroline E. Sutton et al. IMMUNITY
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- (2009) David Bending et al. JOURNAL OF CLINICAL INVESTIGATION
- The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
- (2009) Luigi Franchi et al. NATURE IMMUNOLOGY
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- (2009) Mark D. Pescovitz et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Toll-Like Receptor Signaling Molecule Myd88 Contributes to Pancreatic Beta-Cell Homeostasis in Response to Injury
- (2009) Paul L. Bollyky et al. PLoS One
- Pattern recognition receptors and control of adaptive immunity
- (2008) Noah W. Palm et al. IMMUNOLOGICAL REVIEWS
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- (2008) Li Wen et al. NATURE
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