Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms

Omega-3 Fatty Acid Formulations in Cardiovascular Disease: Dietary Supplements are Not Substitutes for Prescription Products

(2016) Jonathan Fialkow   American Journal of Cardiovascular Drugs

The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation

(2016) Sesquile Ramon et al.   AMERICAN JOURNAL OF PATHOLOGY

Resolvin E1 attenuates atherosclerosis in absence of cholesterol-lowering effects and on top of atorvastatin

(2016) Kanita Salic et al.   ATHEROSCLEROSIS

Resolvin D1 protects the liver from ischemia/reperfusion injury by enhancing M2 macrophage polarization and efferocytosis

(2016) Jung-Woo Kang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Omega-3 fatty acid supplementation influences the whole blood transcriptome in women with obesity, associated with pro-resolving lipid mediator production

(2016) Anna Polus et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

n-3 Fatty acid supplementation and proresolving mediators of inflammation

(2016) Anne E. Barden et al.   CURRENT OPINION IN LIPIDOLOGY

Specialized proresolving lipid mediators in patients with coronary artery disease and their potential for clot remodeling

(2016) Tarec K. Elajami et al.   FASEB JOURNAL

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

(2016) Krishnaraj S. Rathod et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D3 Is Dysregulated in Arthritis and Reduces Arthritic Inflammation

(2016) Hildur H. Arnardottir et al.   JOURNAL OF IMMUNOLOGY

Synthesis of 13(R)-Hydroxy-7Z,10Z,13R,14E,16Z,19Z Docosapentaenoic Acid (13R-HDPA) and Its Biosynthetic Conversion to the 13-Series Resolvins

(2016) Karoline G. Primdahl et al.   JOURNAL OF NATURAL PRODUCTS

Death-defying plaque cells

(2016) Ira Tabas   NATURE

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages

(2016) Jesmond Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specialised pro-resolving mediators of inflammation in inflammatory arthritis

(2016) Anne E. Barden et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses

(2016) Valerio Chiurchiù et al.   Science Translational Medicine

The role of neutrophils in inflammation resolution

(2016) Hefin R. Jones et al.   SEMINARS IN IMMUNOLOGY

Key mechanisms governing resolution of lung inflammation

(2016) C. T. Robb et al.   Seminars in Immunopathology

Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution

(2016) Bangwei Luo et al.   Nature Communications

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Resolvin D4 stereoassignment and its novel actions in host protection and bacterial clearance

(2016) Jeremy W. Winkler et al.   Scientific Reports

Pathway Markers for Pro-resolving Lipid Mediators in Maternal and Umbilical Cord Blood: A Secondary Analysis of the Mothers, Omega-3, and Mental Health Study

(2016) Ellen L. Mozurkewich et al.   Frontiers in Pharmacology

Identification and Actions of a Novel Third Maresin Conjugate in Tissue Regeneration: MCTR3

(2016) Jesmond Dalli et al.   PLoS One

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

The Regulation of Proresolving Lipid Mediator Profiles in Baboon Pneumonia by Inhaled Carbon Monoxide

(2015) Jesmond Dalli et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Determination of ω-6 and ω-3 PUFA metabolites in human urine samples using UPLC/MS/MS

(2015) Ai Sasaki et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Resolution of Inflammation by Resolvin D1 Is Essential for Peroxisome Proliferator–activated Receptor-γ–mediated Analgesia during Postincisional Pain Development in Type 2 Diabetes

(2015) Takayuki Saito et al.   ANESTHESIOLOGY

Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis

(2015) H. Hasturk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Role of omega-3 PUFA-derived mediators, the protectins, in influenza virus infection

(2015) Yumiko Imai   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome

(2015) Charles N. Serhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Resolvins AT-D1 and E1 differentially impact functional outcome, post-traumatic sleep, and microglial activation following diffuse brain injury in the mouse

(2015) Jordan L. Harrison et al.   BRAIN BEHAVIOR AND IMMUNITY

Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α

(2015) Kyle L. Flannigan et al.   FASEB JOURNAL

Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways

(2015) Jesmond Dalli et al.   FASEB JOURNAL

Hydrogen Sulfide Protects from Colitis and Restores Intestinal Microbiota Biofilm and Mucus Production

(2015) Jean-Paul Motta et al.   INFLAMMATORY BOWEL DISEASES

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Female-Specific Downregulation of Tissue Polymorphonuclear Neutrophils Drives Impaired Regulatory T Cell and Amplified Effector T Cell Responses in Autoimmune Dry Eye Disease

(2015) Yuan Gao et al.   JOURNAL OF IMMUNOLOGY

Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages

(2015) Marius Aursnes et al.   JOURNAL OF NATURAL PRODUCTS

Effect of enriching the diet with menhaden oil or daily treatment with resolvin D1 on neuropathy in a mouse model of type 2 diabetes

(2015) Hanna Shevalye et al.   JOURNAL OF NEUROPHYSIOLOGY

Human milk proresolving mediators stimulate resolution of acute inflammation

(2015) H Arnardottir et al.   Mucosal Immunology

Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections

(2015) Jesmond Dalli et al.   NATURE MEDICINE

Inflammation's stop signals

(2015) M. Leslie   SCIENCE

The resolution of inflammation: New mechanisms in patho-physiology open opportunities for pharmacology

(2015) Mauro Perretti   SEMINARS IN IMMUNOLOGY

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

Resolution Pharmacology: Opportunities for Therapeutic Innovation in Inflammation

(2015) Mauro Perretti et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neuroprotectin/protectin D1: endogenous biosynthesis and actions on diabetic macrophages in promoting wound healing and innervation impaired by diabetes

(2014) Song Hong et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resolvin D1 reverses reactivity and Ca2+ sensitivity induced by ET-1, TNF-α, and IL-6 in the human pulmonary artery

(2014) Roddy Hiram et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1

(2014) Masakazu Shinohara et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

(2014) Peter Libby et al.   CIRCULATION RESEARCH

Proresolving Lipid Mediators and Mechanisms in the Resolution of Acute Inflammation

(2014) Christopher D. Buckley et al.   IMMUNITY

Impact of Resolvin E1 on Murine Neutrophil Phagocytosis in Type 2 Diabetes

(2014) Bruno S. Herrera et al.   INFECTION AND IMMUNITY

MicroRNA-181b Regulates ALX/FPR2 Receptor Expression and Proresolution Signaling in Human Macrophages

(2014) Anna Maria Pierdomenico et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid Appearance of Resolvin Precursors in Inflammatory Exudates: Novel Mechanisms in Resolution

(2014) K. Kasuga et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory effects of resolvin-D1 on human corneal epithelial cells: in vitro study

(2014) Nir Erdinest et al.   Journal of Inflammation-London

Synthesis and Anti-inflammatory and Pro-resolving Activities of 22-OH-PD1, a Monohydroxylated Metabolite of Protectin D1

(2014) Jørn E. Tungen et al.   JOURNAL OF NATURAL PRODUCTS

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Protectin DX alleviates insulin resistance by activating a myokine-liver glucoregulatory axis

(2014) Phillip J White et al.   NATURE MEDICINE

Plasma Metabolomics in Human Pulmonary Tuberculosis Disease: A Pilot Study

(2014) Jennifer K. Frediani et al.   PLoS One

Phospholipase A2 regulates eicosanoid class switching during inflammasome activation

(2014) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection

(2014) J. Dalli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 reduces hepatic fibrosis in mice with Schistosoma japonicum infection

(2014) WENHONG QIU et al.   Experimental and Therapeutic Medicine

Eosinophils in the Lung – Modulating Apoptosis and Efferocytosis in Airway Inflammation

(2014) Jennifer M. Felton et al.   Frontiers in Immunology

Human inflammatory and resolving lipid mediator responses to resistance exercise and ibuprofen treatment

(2013) James F. Markworth et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Novel R-roscovitine NO-donor hybrid compounds as potential pro-resolution of inflammation agents

(2013) Gabriele Montanaro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

(2013) Matthew Spite et al.   Cell Metabolism

Resolution phase lipid mediators of inflammation: agonists of resolution

(2013) Charles N. Serhan et al.   CURRENT OPINION IN PHARMACOLOGY

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

Resolvin D1 primes the resolution process initiated by calorie restriction in obesity-induced steatohepatitis

(2013) Bibiana Rius et al.   FASEB JOURNAL

The role of pro-resolution lipid mediators in infectious disease

(2013) Clark D. Russell et al.   IMMUNOLOGY

LC–MS/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites

(2013) Pauline Le Faouder et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Inhaled Carbon Monoxide Accelerates Resolution of Inflammation via Unique Proresolving Mediator-Heme Oxygenase-1 Circuits

(2013) N. Chiang et al.   JOURNAL OF IMMUNOLOGY

Maternal dietary omega-3 fatty acid intake increases resolvin and protectin levels in the rat placenta

(2013) Megan L. Jones et al.   JOURNAL OF LIPID RESEARCH

High levels of anti-inflammatory and pro-resolving lipid mediators lipoxins and resolvins and declining docosahexaenoic acid levels in human milk during the first month of lactation

(2013) Gisela Adrienne Weiss et al.   Lipids in Health and Disease

Resolvin D1 and aspirin-triggered resolvin D1 regulate histamine-stimulated conjunctival goblet cell secretion

(2013) D Li et al.   Mucosal Immunology

The Human Urine Metabolome

(2013) Souhaila Bouatra et al.   PLoS One

Biasing the lipoxin A4/formyl peptide receptor 2 pushes inflammatory resolution

(2013) J. G. Filep   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses

(2013) S. N. Cooray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

(2013) I. Tabas et al.   SCIENCE

Resolvin D1 Limits Polymorphonuclear Leukocyte Recruitment to Inflammatory Loci

(2012) Lucy V. Norling et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators

(2012) J. Dalli et al.   BLOOD

Efficacy and safety of 15(R/S)-methyl-lipoxin A4in topical treatment of infantile eczema

(2012) S.-H. Wu et al.   BRITISH JOURNAL OF DERMATOLOGY

Resolvins D1, D2, and Other Mediators of Self-Limited Resolution of Inflammation in Human Blood following n-3 Fatty Acid Supplementation

(2012) E. Mas et al.   CLINICAL CHEMISTRY

Resolvin E1 (RX-10001) Reduces Corneal Epithelial Barrier Disruption and Protects Against Goblet Cell Loss in a Murine Model of Dry Eye

(2012) Cintia S. de Paiva et al.   CORNEA

Proresolution Therapy for the Treatment of Delayed Healing of Diabetic Wounds

(2012) Y. Tang et al.   DIABETES

Novel aspirin-triggered neuroprotectin D1 attenuates cerebral ischemic injury after experimental stroke

(2012) Nicolas G. Bazan et al.   EXPERIMENTAL NEUROLOGY

Lipoxin A4 attenuates adipose inflammation

(2012) Emma Börgeson et al.   FASEB JOURNAL

Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain

(2012) Charles N. Serhan et al.   FASEB JOURNAL

Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients

(2012) Jun Yang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification and Structure Determination of Novel Anti-inflammatory Mediator Resolvin E3, 17,18-Dihydroxyeicosapentaenoic Acid

(2012) Yosuke Isobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells

(2012) S. Ramon et al.   JOURNAL OF IMMUNOLOGY

Resolvin E2 Formation and Impact in Inflammation Resolution

(2012) S. F. Oh et al.   JOURNAL OF IMMUNOLOGY

Resolvins E1 and D1 inhibit interstitial fibrosis in the obstructed kidney via inhibition of local fibroblast proliferation

(2012) Xinli Qu et al.   JOURNAL OF PATHOLOGY

Infection regulates pro-resolving mediators that lower antibiotic requirements

(2012) Nan Chiang et al.   NATURE

Microfluidic chambers for monitoring leukocyte trafficking and humanized nano-proresolving medicines interactions

(2012) C. N. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin E1 promotes phagocytosis-induced neutrophil apoptosis and accelerates resolution of pulmonary inflammation

(2012) D. El Kebir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fresh Approaches to Anti-Infective Therapies

(2012) C. Nathan   Science Translational Medicine

Resolution of inflammation: therapeutic potential of pro-resolving lipids in type 2 diabetes mellitus and associated renal complications

(2012) Emma Börgeson et al.   Frontiers in Immunology

Pro-Resolving Lipid Mediators (SPMs) and Their Actions in Regulating miRNA in Novel Resolution Circuits in Inflammation

(2012) Antonio Recchiuti et al.   Frontiers in Immunology

Resolvins and Protectins in Inflammation Resolution

(2011) Charles N. Serhan et al.   CHEMICAL REVIEWS

Novel Proresolving Aspirin-Triggered DHA Pathway

(2011) Charles N. Serhan et al.   CHEMISTRY & BIOLOGY

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

The resolution of inflammation: the devil in the flask and in the details

(2011) Charles N. Serhan   FASEB JOURNAL

Estrogen negatively regulates epithelial wound healing and protective lipid mediator circuits in the cornea

(2011) Samantha B. Wang et al.   FASEB JOURNAL

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Conjunctival Goblet Cell Secretion Stimulated by Leukotrienes Is Reduced by Resolvins D1 and E1 To Promote Resolution of Inflammation

(2011) Darlene A. Dartt et al.   JOURNAL OF IMMUNOLOGY

Antimicrobial Aspects of Inflammatory Resolution in the Mucosa: A Role for Proresolving Mediators

(2011) E. L. Campbell et al.   JOURNAL OF IMMUNOLOGY

Aspirin-Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis

(2010) Karen J. Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Anti-inflammatory Agents: Present and Future

(2010) Charles A. Dinarello   CELL

Docosahexaenoic acid, protectins and dry eye

(2010) Maria S Cortina et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Resolution, the grail for healthy ocular inflammation

(2010) Karsten Gronert   EXPERIMENTAL EYE RESEARCH

Resolution of Inflammation in Murine Autoimmune Arthritis Is Disrupted by Cyclooxygenase-2 Inhibition and Restored by Prostaglandin E2-Mediated Lipoxin A4 Production

(2010) M. M. Y. Chan et al.   JOURNAL OF IMMUNOLOGY

Resolvin E1 Improves Tear Production and Decreases Inflammation in a Dry Eye Mouse Model

(2010) Na Li et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Dichotomy in duration and severity of acute inflammatory responses in humans arising from differentially expressed proresolution pathways

(2010) T. Morris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolvin D1 binds human phagocytes with evidence for proresolving receptors

(2010) S. Krishnamoorthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis

(2009) V. Martins et al.   JOURNAL OF IMMUNOLOGY

Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators

(2008) Aksam J. Merched et al.   FASEB JOURNAL

Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions

(2008) Charles N. Serhan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Management of Inflammation in Periodontal Disease

(2008) Thomas E. Van Dyke   JOURNAL OF PERIODONTOLOGY