Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance

Low Serum Sex Hormone-Binding Globulin Associated with Insulin Resistance in Men with Nonalcoholic Fatty Liver Disease

(2017) Juan Ye et al.   HORMONE AND METABOLIC RESEARCH

Treatment of nonalcoholic fatty liver disease: role of AMPK

(2016) Brennan K. Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice

(2016) Keita Chikamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plasma fetuin-A triggers inflammatory changes in macrophages and adipocytes by acting as an adaptor protein between NEFA and TLR-4

(2016) Satinath Mukhopadhyay et al.   DIABETOLOGIA

A novel hepatokine, HFREP1, plays a crucial role in the development of insulin resistance and type 2 diabetes

(2016) Hung-Tsung Wu et al.   DIABETOLOGIA

Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes

(2016) Zobair M. Younossi et al.   HEPATOLOGY

Association Between Serum Fibroblast Growth Factor 21 and Mortality Among Patients With Coronary Artery Disease

(2016) Qing Li et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Short communication: Proteins from circulating exosomes represent metabolic state in transition dairy cows

(2016) M.A. Crookenden et al.   JOURNAL OF DAIRY SCIENCE

Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes

(2016) Wieneke Dijk et al.   JOURNAL OF LIPID RESEARCH

Genetics of nonalcoholic fatty liver disease

(2016) Paola Dongiovanni et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats

(2016) Geraldine Harriman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic fat content is a determinant of metabolic phenotypes and increased carotid intima-media thickness in obese adults

(2016) Huijie Zhang et al.   Scientific Reports

Statins Increase Mitochondrial and Peroxisomal Fatty Acid Oxidation in the Liver and Prevent Non-Alcoholic Steatohepatitis in Mice

(2016) Han-Sol Park et al.   Diabetes & Metabolism Journal

MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study

(2015) Pi-Jung Hsiao et al.   BMC Medical Genetics

Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism

(2015) Ruth C. Meex et al.   Cell Metabolism

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Association Between Endogenous Sex Hormones and Liver Fat in a Multiethnic Study of Atherosclerosis

(2015) Mariana Lazo et al.   Clinical Gastroenterology and Hepatology

RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice

(2015) Xiang Ma et al.   DIABETOLOGIA

Serum Adropin Level in Patients with Stable Coronary Artery Disease

(2015) Liang-Ping Zhao et al.   Heart Lung and Circulation

LECT2 induces atherosclerotic inflammatory reaction via CD209 receptor-mediated JNK phosphorylation in human endothelial cells

(2015) Hwan-Jin Hwang et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

(2015) Chiara Degirolamo et al.   NATURE REVIEWS DRUG DISCOVERY

Regulation of metabolism by the innate immune system

(2015) Denise E. Lackey et al.   Nature Reviews Endocrinology

Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1

(2015) Chu-Sook Kim et al.   Nutrition & Metabolism

Ceramides – Lipotoxic Inducers of Metabolic Disorders

(2015) Bhagirath Chaurasia et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Therapeutic effects of adropin on glucose tolerance and substrate utilization in diet-induced obese mice with insulin resistance

(2015) Su Gao et al.   Molecular Metabolism

Hepatokines as a Link between Obesity and Cardiovascular Diseases

(2015) Hye Jin Yoo et al.   Diabetes & Metabolism Journal

Proton magnetic resonance spectroscopy reveals increased hepatic lipid content after a single high-fat meal with no additional modulation by added protein

(2014) Lucas Lindeboom et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

RBP4 Activates Antigen-Presenting Cells, Leading to Adipose Tissue Inflammation and Systemic Insulin Resistance

(2014) Pedro M. Moraes-Vieira et al.   Cell Metabolism

LECT2 Functions as a Hepatokine That Links Obesity to Skeletal Muscle Insulin Resistance

(2014) Fei Lan et al.   DIABETES

Regulation of Substrate Oxidation Preferences in Muscle by the Peptide Hormone Adropin

(2014) S. Gao et al.   DIABETES

Adiponectin Upregulates SHBG Production: Molecular Mechanisms and Potential Implications

(2014) Rafael Simó et al.   ENDOCRINOLOGY

Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children

(2014) B-J Ko et al.   INTERNATIONAL JOURNAL OF OBESITY

Investigation of adropin and leptin levels in pediatric obesity-related nonalcoholic fatty liver disease

(2014) Oya Sayın et al.   JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM

Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2014) Marie Ng et al.   LANCET

De novo lipogenesis in health and disease

(2014) Fatima Ameer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

(2014) Rachel J. Perry et al.   NATURE

Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance

(2014) Peter Arner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A Novel APOB Mutation Identified by Exome Sequencing Cosegregates With Steatosis, Liver Cancer, and Hypocholesterolemia

(2013) Angelo B. Cefalù et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; Should we care?

(2013) Ebenezer T. Oni et al.   ATHEROSCLEROSIS

Secretome profiling of primary human skeletal muscle cells

(2013) Sonja Hartwig et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Effects of LY2405319, an FGF21 Analog, in Obese Human Subjects with Type 2 Diabetes

(2013) Gregory Gaich et al.   Cell Metabolism

MRI measurement of liver fat content predicts the metabolic syndrome

(2013) P.-H. Ducluzeau et al.   DIABETES & METABOLISM

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics

(2013) Jacklyn N. Hellwege et al.   GENE

Fatty liver score and 15-year incidence of type 2 diabetes

(2013) Anna Kotronen et al.   Hepatology International

The role of Hepassocin in the development of non-alcoholic fatty liver disease

(2013) Hung-Tsung Wu et al.   JOURNAL OF HEPATOLOGY

Serum FGF21 increases with hepatic fat accumulation in pediatric onset intestinal failure

(2013) Annika Mutanen et al.   JOURNAL OF HEPATOLOGY

Non-alcoholic fatty liver disease independently predicts prediabetes during a 7-year prospective follow-up

(2013) Shira Zelber-Sagi et al.   LIVER INTERNATIONAL

Circulating fetuin-A and free fatty acids interact to predict insulin resistance in humans

(2013) Norbert Stefan et al.   NATURE MEDICINE

Relationships of body composition and liver fat content with insulin resistance in obesity-matched adolescents and adults

(2013) Katarzyna Linder et al.   Obesity

Salsalate and Adiponectin Improve Palmitate-Induced Insulin Resistance via Inhibition of Selenoprotein P through the AMPK-FOXO1α Pathway

(2013) Tae Woo Jung et al.   PLoS One

Downstream Signaling Pathways in Mouse Adipose Tissues Following Acute In Vivo Administration of Fibroblast Growth Factor 21

(2013) Eric S. Muise et al.   PLoS One

Increased Selenoprotein P Levels in Subjects with Visceral Obesity and Nonalcoholic Fatty Liver Disease

(2013) Hae Yoon Choi et al.   Diabetes & Metabolism Journal

Metabolic Consequences of Hepatic Steatosis in Overweight and Obese Adolescents

(2012) B. A. Wicklow et al.   DIABETES CARE

Identification and Functional Characterization of Protein Kinase A Phosphorylation Sites in the Major Lipolytic Protein, Adipose Triglyceride Lipase

(2012) Joanne Pagnon et al.   ENDOCRINOLOGY

A high-selenium diet induces insulin resistance in gestating rats and their offspring

(2012) Min-Shu Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Intrahepatic Diacylglycerol Content Is Associated With Hepatic Insulin Resistance in Obese Subjects

(2012) Faidon Magkos et al.   GASTROENTEROLOGY

Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5-year prospective cohort study

(2012) Sung Keun Park et al.   HEPATOLOGY

Low Circulating Adropin Concentrations with Obesity and Aging Correlate with Risk Factors for Metabolic Disease and Increase after Gastric Bypass Surgery in Humans

(2012) Andrew A. Butler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

iTRAQ-Based Quantitative Protein Expression Profiling and MRM Verification of Markers in Type 2 Diabetes

(2012) Prabhjit Kaur et al.   JOURNAL OF PROTEOME RESEARCH

IL1β Down-regulation of Sex Hormone-Binding Globulin Production by Decreasing HNF-4α Via MEK-1/2 and JNK MAPK Pathways

(2012) Rafael Simó et al.   MOLECULAR ENDOCRINOLOGY

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Muscles, exercise and obesity: skeletal muscle as a secretory organ

(2012) Bente K. Pedersen et al.   Nature Reviews Endocrinology

Adropin Deficiency Is Associated With Increased Adiposity and Insulin Resistance

(2012) K. Ganesh Kumar et al.   Obesity

Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes

(2012) Hirofumi Misu et al.   PLoS One

Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet

(2012) Anja Thomas et al.   PROTEOMICS

Dissociating fatty liver and diabetes

(2012) Zheng Sun et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Polysome Profiling in Liver Identifies Dynamic Regulation of Endoplasmic Reticulum Translatome by Obesity and Fasting

(2012) Suneng Fu et al.   PLoS Genetics

Alcohol Disrupts Endoplasmic Reticulum Function and Protein Secretion in Hepatocytes

(2011) Deanna L. Howarth et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Angiopoietin-like 4: a decade of research

(2011) Pengcheng Zhu et al.   BIOSCIENCE REPORTS

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

(2011) Nishanth E. Sunny et al.   Cell Metabolism

Potential Role of Tumor Necrosis Factor-  in Downregulating Sex Hormone-Binding Globulin

(2011) R. Simo et al.   DIABETES

Global variability in diabetes mellitus and its association with body weight and primary healthcare support in 49 low- and middle-income developing countries

(2011) L. Liu et al.   DIABETIC MEDICINE

RBP4: a controversial adipokine

(2011) Primoz Kotnik et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Fetuin A in nonalcoholic fatty liver disease: in vivo and in vitro studies

(2011) John Willy Haukeland et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Deficiency of liver adipose triglyceride lipase in mice causes progressive hepatic steatosis

(2011) Jiang Wei Wu et al.   HEPATOLOGY

Serum Selenoprotein P Levels in Patients with Type 2 Diabetes and Prediabetes: Implications for Insulin Resistance, Inflammation, and Atherosclerosis

(2011) S. J. Yang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Three Weeks on a High-Fat Diet Increases Intrahepatic Lipid Accumulation and Decreases Metabolic Flexibility in Healthy Overweight Men

(2011) Noud A. van Herpen et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

(2011) N. Kumashiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Fatty Liver Disease: Old Questions and New Insights

(2011) J. C. Cohen et al.   SCIENCE

A Liver-Derived Secretory Protein, Selenoprotein P, Causes Insulin Resistance

(2010) Hirofumi Misu et al.   Cell Metabolism

Early Hepatic Insulin Resistance Precedes the Onset of Diabetes in Obese C57BLKS-db/db Mice

(2010) R. C. Davis et al.   DIABETES

Relationships of Circulating Sex Hormone-Binding Globulin With Metabolic Traits in Humans

(2010) A. Peter et al.   DIABETES

Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents

(2010) E. D'Adamo et al.   DIABETES CARE

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

(2010) S. M. Turpin et al.   DIABETOLOGIA

The impact of liver fat vs visceral fat in determining categories of prediabetes

(2010) K. Kantartzis et al.   DIABETOLOGIA

ER Stress in Adipocytes Inhibits Insulin Signaling, Represses Lipolysis, and Alters the Secretion of Adipokines Without Inhibiting Glucose Transport

(2010) L. Xu et al.   HORMONE AND METABOLIC RESEARCH

Impairedde NovoCholine Synthesis Explains Why PhosphatidylethanolamineN-Methyltransferase-deficient Mice Are Protected from Diet-induced Obesity

(2010) René L. Jacobs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease

(2010) Irina A. Kirpich et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus

(2010) Nathalie C. Leite et al.   LIVER INTERNATIONAL

Increased Mitochondrial Oxidative Phosphorylation in the Liver Is Associated With Obesity and Insulin Resistance

(2010) David A. Buchner et al.   Obesity

Circulating retinol-binding protein 4, cardiovascular risk factors and prevalent cardiovascular disease in elderly

(2009) Erik Ingelsson et al.   ATHEROSCLEROSIS

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

(2009) A. O. Chavez et al.   DIABETES CARE

Recombinant human hepassocin stimulates proliferation of hepatocytes in vivo and improves survival in rats with fulminant hepatic failure

(2009) C. Y. Li et al.   GUT

Abnormal hepatic energy homeostasis in type 2 diabetes

(2009) Julia Szendroedi et al.   HEPATOLOGY

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

(2009) John R.B. Perry et al.   HUMAN MOLECULAR GENETICS

A Highly Conserved Motif within the NH2-terminal Coiled-coil Domain of Angiopoietin-like Protein 4 Confers Its Inhibitory Effects on Lipoprotein Lipase by Disrupting the Enzyme Dimerization

(2009) Ming-hon Yau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes

(2009) Partha Chakrabarti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

(2009) E. Fabbrini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and Characterization of Metabolically Benign Obesity in Humans

(2008) Norbert Stefan   ARCHIVES OF INTERNAL MEDICINE

Sex hormones, sex hormone binding globulin, and abdominal aortic calcification in women and men in the multi-ethnic study of atherosclerosis (MESA)

(2008) Erin D. Michos et al.   ATHEROSCLEROSIS

Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism

(2008) K. Ganesh Kumar et al.   Cell Metabolism

Plasma Fetuin-A Levels and the Risk of Type 2 Diabetes

(2008) N. Stefan et al.   DIABETES

Serum FGF21 Levels Are Increased in Obesity and Are Independently Associated With the Metabolic Syndrome in Humans

(2008) X. Zhang et al.   DIABETES

Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator-Activated Receptor (PPAR)-  and Is of Metabolic Relevance in Humans

(2008) H. Staiger et al.   DIABETES

Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice

(2008) J. Xu et al.   DIABETES

Abdominal Visceral Fat Reduction Is Associated with Favorable Changes of Serum Retinol Binding Protein-4 in Nondiabetic Subjects

(2008) Ji-Won LEE et al.   ENDOCRINE JOURNAL

FGF21 attenuates lipolysis in human adipocytes - A possible link to improved insulin sensitivity

(2008) Peter Arner et al.   FEBS LETTERS

Liver, Muscle, and Adipose Tissue Insulin Action Is Directly Related to Intrahepatic Triglyceride Content in Obese Subjects

(2008) Kevin M. Korenblat et al.   GASTROENTEROLOGY

Comprehensive and quantitative proteome profiling of the mouse liver and plasma

(2008) Keane K. Y. Lai et al.   HEPATOLOGY

Increased overall mortality and liver-related mortality in non-alcoholic fatty liver disease

(2008) Janus P. Ong et al.   JOURNAL OF HEPATOLOGY

Hepatic triacylglycerol accumulation and insulin resistance

(2008) Cynthia A. Nagle et al.   JOURNAL OF LIPID RESEARCH

Alterations in Adipose Tissue and Hepatic Lipid Kinetics in Obese Men and Women With Nonalcoholic Fatty Liver Disease

(2007) Elisa Fabbrini et al.   GASTROENTEROLOGY

Fenofibrate modulates cardiac and hepatic metabolism and increases ischemic tolerance in diet-induced obese mice

(2007) Ellen Aasum et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY