Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

(2012) Kouichi Miura et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Diet, commensals and the intestine as sources of pathogen-associated molecular patterns in atherosclerosis, type 2 diabetes and non-alcoholic fatty liver disease

(2011) Clett Erridge   ATHEROSCLEROSIS

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells

(2011) Timea Csak et al.   HEPATOLOGY

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome is a central player in the induction of obesity and insulin resistance

(2011) R. Stienstra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of Toll-Like Receptors and Their Downstream Molecules in the Development of Nonalcoholic Fatty Liver Disease

(2011) Kouichi Miura et al.   Gastroenterology Research and Practice

Gut Microbiota Is a Key Modulator of Insulin Resistance in TLR 2 Knockout Mice

(2011) Andréa M. Caricilli et al.   PLOS BIOLOGY

Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis

(2010) Chantal A Rivera et al.   BMC GASTROENTEROLOGY

Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression

(2010) Eek Joong Park et al.   CELL

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

(2010) J. A. Ehses et al.   DIABETOLOGIA

Toll-Like Receptor 9 Promotes Steatohepatitis by Induction of Interleukin-1β in Mice

(2010) Kouichi Miura et al.   GASTROENTEROLOGY

Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection

(2010) Brad Q. Starley et al.   HEPATOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

JNK regulation of hepatic manifestations of the metabolic syndrome

(2010) Mark J. Czaja   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The TLR4/TRIF-Mediated Activation of NLRP3 Inflammasome Underlies Endotoxin-Induced Liver Injury in Mice

(2010) Hiroko Tsutsui et al.   Gastroenterology Research and Practice

Inflammasome-mediated regulation of hepatic stellate cells

(2009) Azuma Watanabe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

c-Jun N-terminal Kinase-1 From Hematopoietic Cells Mediates Progression From Hepatic Steatosis to Steatohepatitis and Fibrosis in Mice

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Contribution of TIR domain-containing adapter inducing IFN-β-mediated IL-18 release to LPS-induced liver injury in mice

(2009) Michiko Imamura et al.   JOURNAL OF HEPATOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Beyond insulin resistance: Innate immunity in nonalcoholic steatohepatitis

(2008) Jacquelyn J. Maher et al.   HEPATOLOGY

Toll‐like receptors and adaptor molecules in liver disease: Update

(2008) Ekihiro Seki et al.   HEPATOLOGY