Pathobiology of liver fibrosis: a translational success story

Myocardin related transcription factor A programs epigenetic activation of hepatic stellate cells

(2015) Wenfang Tian et al.   JOURNAL OF HEPATOLOGY

Systematic review: the effects of autologous stem cell therapy for patients with liver disease

(2014) J. K. Moore et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Reversal, maintenance or progression: What happens to the liver after a virologic cure of hepatitis C?

(2014) Youngmin A. Lee et al.   ANTIVIRAL RESEARCH

Cellular and molecular mechanisms in liver fibrogenesis

(2014) Erica Novo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Purinergic Signaling in Liver Disease

(2014) Byron P. Vaughn et al.   DIGESTIVE DISEASES

The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic target

(2014) Wen-Yue Liu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Roles for Chemokines in Liver Disease

(2014) Fabio Marra et al.   GASTROENTEROLOGY

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Immune tolerance in liver disease

(2014) Ian N. Crispe   HEPATOLOGY

Novel role of nuclear receptor rev-erbα in hepatic stellate cell activation: Potential therapeutic target for liver injury

(2014) Ting Li et al.   HEPATOLOGY

Epigenetics in liver disease

(2014) Derek A. Mann   HEPATOLOGY

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

(2014) Michaela Granzow et al.   HEPATOLOGY

GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis in mice

(2014) Irene Delgado et al.   HEPATOLOGY

Alcohol dehydrogenase III exacerbates liver fibrosis by enhancing stellate cell activation and suppressing natural killer cells in mice

(2014) Hyon-Seung Yi et al.   HEPATOLOGY

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+macrophage infiltration in mice

(2014) Christer Baeck et al.   HEPATOLOGY

Hepatic stellate cells contribute to progenitor cells and liver regeneration

(2014) Claus Kordes et al.   JOURNAL OF CLINICAL INVESTIGATION

Collagen proportionate area is superior to other histological methods for sub-classifying cirrhosis and determining prognosis

(2014) Emmanuel Tsochatzis et al.   JOURNAL OF HEPATOLOGY

Image analysis of liver biopsy samples measures fibrosis and predicts clinical outcome

(2014) Yi Huang et al.   JOURNAL OF HEPATOLOGY

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Preparing the ground for tissue regeneration: from mechanism to therapy

(2014) Stuart J Forbes et al.   NATURE MEDICINE

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GIV/Girdin is a central hub for profibrogenic signalling networks during liver fibrosis

(2014) Inmaculada Lopez-Sanchez et al.   Nature Communications

Origins and functions of liver myofibroblasts

(2013) Sara Lemoinne et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response

(2013) Ning Ding et al.   CELL

Contributions of metabolic dysregulation and inflammation to nonalcoholic steatohepatitis, hepatic fibrosis, and cancer

(2013) Abigale Lade et al.   CURRENT OPINION IN ONCOLOGY

Cysteamine: an old drug with new potential

(2013) Martine Besouw et al.   DRUG DISCOVERY TODAY

Free radical biology for medicine: learning from nonalcoholic fatty liver disease

(2013) Gaetano Serviddio et al.   FREE RADICAL BIOLOGY AND MEDICINE

Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease

(2013) Sunder Mudaliar et al.   GASTROENTEROLOGY

Links Between Hepatic Fibrosis, Ductular Reaction, and Progenitor Cell Expansion

(2013) Michael J. Williams et al.   GASTROENTEROLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats

(2013) Len Verbeke et al.   HEPATOLOGY

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

Dysbiosis contributes to fibrogenesis in the course of chronic liver injury in mice

(2013) Samuele De Minicis et al.   HEPATOLOGY

Association Between Sustained Virological Response and All-Cause Mortality Among Patients With Chronic Hepatitis C and Advanced Hepatic Fibrosis

(2013) Adriaan J. van der Meer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development

(2013) Zhengping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolving therapies for liver fibrosis

(2013) Detlef Schuppan et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver sinusoidal endothelial cells and liver regeneration

(2013) Laurie D. DeLeve   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic reticulum stress induces fibrogenic activity in hepatic stellate cells through autophagy

(2013) Virginia Hernández-Gea et al.   JOURNAL OF HEPATOLOGY

Decoding cell death signals in liver inflammation

(2013) Catherine Brenner et al.   JOURNAL OF HEPATOLOGY

Cannabinoid signaling and liver therapeutics

(2013) Ariane Mallat et al.   JOURNAL OF HEPATOLOGY

Molecular MRI of collagen to diagnose and stage liver fibrosis

(2013) Bryan C. Fuchs et al.   JOURNAL OF HEPATOLOGY

Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease

(2013) Rajarshi Banerjee et al.   JOURNAL OF HEPATOLOGY

Using non-invasive biomarkers to identify hepatic fibrosis in people with type 2 diabetes mellitus: The Edinburgh type 2 diabetes study

(2013) Joanne R. Morling et al.   JOURNAL OF HEPATOLOGY

Staging chronic hepatitis C in seven categories using fibrosis biomarker (FibroTest™) and transient elastography (FibroScan®)

(2013) Thierry Poynard et al.   JOURNAL OF HEPATOLOGY

Divergent angiocrine signals from vascular niche balance liver regeneration and fibrosis

(2013) Bi-Sen Ding et al.   NATURE

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Convergent pathways that cause hepatic fibrosis in NASH

(2013) Scott L. Friedman   Nature Reviews Gastroenterology & Hepatology

The Gordian Knot of dysbiosis, obesity and NAFLD

(2013) Wajahat Z. Mehal   Nature Reviews Gastroenterology & Hepatology

From NAFLD to NASH to cirrhosis—new insights into disease mechanisms

(2013) Alexander Wree et al.   Nature Reviews Gastroenterology & Hepatology

Regression of Fibrosis and Reversal of Cirrhosis in Rats by Galectin Inhibitors in Thioacetamide-Induced Liver Disease

(2013) Peter G. Traber et al.   PLoS One

Amplified Inhibition of Stellate Cell Activation Pathways by PPAR-γ, RAR and RXR Agonists

(2013) Efrat Sharvit et al.   PLoS One

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Natural killer and natural killer T cells in liver fibrosis

(2012) Bin Gao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Farnesoid X receptor targeting to treat nonalcoholic steatohepatitis

(2012) Luciano Adorini et al.   DRUG DISCOVERY TODAY

Autophagy Releases Lipid That Promotes Fibrogenesis by Activated Hepatic Stellate Cells in Mice and in Human Tissues

(2012) Virginia Hernández–Gea et al.   GASTROENTEROLOGY

Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism

(2012) Yuping Chen et al.   GASTROENTEROLOGY

Deactivation of Hepatic Stellate Cells During Liver Fibrosis Resolution in Mice

(2012) Juliane S. Troeger et al.   GASTROENTEROLOGY

MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis

(2012) Tomohiro Ogawa et al.   GUT

A morphometric and immunohistochemical study to assess the benefit of a sustained virological response in hepatitis C virus patients with cirrhosis

(2012) Roberta D'Ambrosio et al.   HEPATOLOGY

A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice

(2012) Juan E. Puche et al.   HEPATOLOGY

Hepatic Stellate Cell-derived Delta-like Homolog 1 (DLK1) Protein in Liver Regeneration

(2012) Nian-Ling Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acetyl-CoA Carboxylase 2−/−Mutant Mice are Protected against Fatty Liver under High-fat, High-carbohydrate Dietary andde NovoLipogenic Conditions

(2012) Lutfi Abu-Elheiga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1 receptor antagonist ameliorates inflammasome-dependent alcoholic steatohepatitis in mice

(2012) Jan Petrasek et al.   JOURNAL OF CLINICAL INVESTIGATION

HSC-specific inhibition of Rho-kinase reduces portal pressure in cirrhotic rats without major systemic effects

(2012) Sabine Klein et al.   JOURNAL OF HEPATOLOGY

Clinical evidence for the regression of liver fibrosis

(2012) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Molecular MR imaging of liver fibrosis: A feasibility study using rat and mouse models

(2012) Miloslav Polasek et al.   JOURNAL OF HEPATOLOGY

miR-133a mediates TGF-β-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis

(2012) Christoph Roderburg et al.   JOURNAL OF HEPATOLOGY

miR-122 regulates collagen production via targeting hepatic stellate cells and suppressing P4HA1 expression

(2012) Jiang Li et al.   JOURNAL OF HEPATOLOGY

Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis

(2012) Laura J Dixon et al.   LABORATORY INVESTIGATION

Regression of cirrhosis during treatment with tenofovir disoproxil fumarate for chronic hepatitis B: a 5-year open-label follow-up study

(2012) Patrick Marcellin et al.   LANCET

Multigenerational epigenetic adaptation of the hepatic wound-healing response

(2012) Müjdat Zeybel et al.   NATURE MEDICINE

Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis

(2012) T. Kisseleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

(2012) P. Ramachandran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNMT1-mediated PTEN hypermethylation confers hepatic stellate cell activation and liver fibrogenesis in rats

(2012) Er-Bao Bian et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver stiffness diminishes with antiviral response in chronic hepatitis C

(2011) C. Hézode et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

AT1R-CB1R heteromerization reveals a new mechanism for the pathogenic properties of angiotensin II

(2011) Raphael Rozenfeld et al.   EMBO JOURNAL

Role of Differentiation of Liver Sinusoidal Endothelial Cells in Progression and Regression of Hepatic Fibrosis in Rats

(2011) Guanhua Xie et al.   GASTROENTEROLOGY

Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis

(2011) J. Kluwe et al.   GUT

The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91phox mediate hepatic fibrosis in mice

(2011) Yong-Han Paik et al.   HEPATOLOGY

Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice

(2011) Ruchi Bansal et al.   HEPATOLOGY

Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function

(2011) James A. Thomas et al.   HEPATOLOGY

Elastin accumulation is regulated at the level of degradation by macrophage metalloelastase (MMP-12) during experimental liver fibrosis

(2011) Antonella Pellicoro et al.   HEPATOLOGY

Quantitative liver function tests improve the prediction of clinical outcomes in chronic hepatitis C: Results from the hepatitis C antiviral long-term treatment against cirrhosis trial

(2011) Gregory T. Everson et al.   HEPATOLOGY

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung Fibroblasts

(2011) Larry L. Luchsinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Imatinib Mesylate Improves Liver Regeneration and Attenuates Liver Fibrogenesis in CCL4-Treated Mice

(2011) Wen-Ling Kuo et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: A step toward the truth in the absence of a gold standard

(2011) Thierry Poynard et al.   JOURNAL OF HEPATOLOGY

Scraping fibrosis: Expressway to the core of fibrosis

(2011) Wajahat Z Mehal et al.   NATURE MEDICINE

Stimulating healthy tissue regeneration by targeting the 5-HT2B receptor in chronic liver disease

(2011) Mohammad R Ebrahimkhani et al.   NATURE MEDICINE

Improvement of Nonalcoholic Fatty Liver Disease After Bariatric Surgery in Morbidly Obese Chinese Patients

(2011) Chi-Ming Tai et al.   OBESITY SURGERY

In Vivo Liver Regeneration Potential of Human Induced Pluripotent Stem Cells from Diverse Origins

(2011) H. Liu et al.   Science Translational Medicine

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

(2010) JS Swaney et al.   BRITISH JOURNAL OF PHARMACOLOGY

Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction

(2010) Eric M. Small et al.   CIRCULATION RESEARCH

PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis

(2010) J.S. Duffield et al.   DRUG NEWS & PERSPECTIVES

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

(2010) Simon W. Beaven et al.   GASTROENTEROLOGY

Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis

(2010) Christoph Roderburg et al.   HEPATOLOGY

Down-regulation of cyclin E1 expression by microrna-195 accounts for interferon-β-induced inhibition of hepatic stellate cell proliferation

(2010) Yumiko Sekiya et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of a cirrhosis risk score for the early prediction of fibrosis progression in hepatitis C patients with minimal liver disease

(2010) Eric Trépo et al.   JOURNAL OF HEPATOLOGY

Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment

(2010) Vivian Barry-Hamilton et al.   NATURE MEDICINE

Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis

(2010) Arun J. Sanyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Farnesoid X Receptor Critically Determines the Fibrotic Response in Mice but Is Expressed to a Low Extent in Human Hepatic Stellate Cells and Periductal Myofibroblasts

(2009) Peter Fickert et al.   AMERICAN JOURNAL OF PATHOLOGY

Fibrosis progression in chronic hepatitis C: Morphometric image analysis in the HALT-C trial

(2009) Zachary D. Goodman et al.   HEPATOLOGY

Hepatic recruitment of the inflammatory Gr1+monocyte subset upon liver injury promotes hepatic fibrosis

(2009) Karlin Raja Karlmark et al.   HEPATOLOGY

Now there are many (stages) where before there was one: In search of a pathophysiological classification of cirrhosis

(2009) Guadalupe Garcia-Tsao et al.   HEPATOLOGY

Ghrelin attenuates hepatocellular injury and liver fibrogenesis in rodents and influences fibrosis progression in humans

(2009) Montserrat Moreno et al.   HEPATOLOGY

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

(2009) Sushant Bhatnagar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB signalling: Embracing complexity to achieve translation

(2009) Jayashree Bagchi Chakraborty et al.   JOURNAL OF HEPATOLOGY

Liver natural killer and natural killer T cells: immunobiology and emerging roles in liver diseases

(2009) B. Gao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

A continuous13C methacetin breath test for noninvasive assessment of intrahepatic inflammation and fibrosis in patients with chronic HCV infection and normal ALT

(2008) G. Lalazar et al.   JOURNAL OF VIRAL HEPATITIS

Inhibition of Integrin αvβ6, an Activator of Latent Transforming Growth Factor-β, Prevents Radiation-induced Lung Fibrosis

(2007) Khalid Puthawala et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE