Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2
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Title
Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 4, Pages 1264
Publisher
MDPI AG
Online
2018-04-24
DOI
10.3390/ijms19041264
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Note: Only part of the references are listed.- Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling
- (2018) Katherine M. Thieltges et al. ANGIOGENESIS
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- (2018) Yohei Shibata et al. CLINICA CHIMICA ACTA
- Architecture and hydration of the arginine-binding site of neuropilin-1
- (2018) Filipa Mota et al. FEBS Journal
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- (2018) Kevin Danastas et al. REPRODUCTION FERTILITY AND DEVELOPMENT
- NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs
- (2018) Leigh A. Stoddart et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease
- (2018) et al. Genes
- Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats
- (2017) Joanne J. Carter et al. FASEB JOURNAL
- The Different Effects of VEGFA121 and VEGFA165 on Regulating Angiogenesis Depend on Phosphorylation Sites of VEGFR2
- (2017) Wang Shiying et al. INFLAMMATORY BOWEL DISEASES
- Chemotherapy induces alternative transcription and splicing: Facts and hopes for cancer treatment
- (2017) Charles A. Lambert et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- VEGF and the diabetic kidney: More than too much of a good thing
- (2017) Syamantak Majumder et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A
- (2017) Sandra Markovic-Mueller et al. STRUCTURE
- Direct Effects of Anti-Angiogenic Therapies on Tumor Cells: VEGF Signaling
- (2017) Thomas Simon et al. TRENDS IN MOLECULAR MEDICINE
- VEGF-A121a binding to Neuropilins – A concept revisited
- (2017) Sarvenaz Sarabipour et al. Cell Adhesion & Migration
- Dynamics and implications of circulating anti-angiogenic VEGF-A165b isoform in patients with ST-elevation myocardial infarction
- (2017) Luisa Hueso et al. Scientific Reports
- A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
- (2017) Lindsay E. Clegg et al. PLoS Computational Biology
- Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex
- (2017) Guijun Shang et al. eLife
- RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAxxxb isoforms
- (2017) Stephen Bridgett et al. Scientific Reports
- Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner
- (2017) Dimitris Basagiannis et al. Scientific Reports
- Evidence for Pro-angiogenic Functions of VEGF-Ax
- (2016) Hong Xin et al. CELL
- Diabetic macular oedema: pathophysiology, management challenges and treatment resistance
- (2016) Bobak Bahrami et al. DIABETOLOGIA
- Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding
- (2016) Dimitris Basagiannis et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis.
- (2016) Dimitris Basagiannis et al. JOURNAL OF CELL SCIENCE
- Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma
- (2016) Xi Ye et al. JOURNAL OF PATHOLOGY
- Ten years of anti-vascular endothelial growth factor therapy
- (2016) Napoleone Ferrara et al. NATURE REVIEWS DRUG DISCOVERY
- Mechanisms and regulation of endothelial VEGF receptor signalling
- (2016) Michael Simons et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Targeting VEGF in eye neovascularization: What's new?
- (2016) Marialaura Amadio et al. PHARMACOLOGICAL RESEARCH
- Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review
- (2016) Xiaodong Sun et al. Drug Design Development and Therapy
- Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies
- (2016) Mélanie Guyot et al. Oncotarget
- VEGFR-2 conformational switch in response to ligand binding
- (2016) Sarvenaz Sarabipour et al. eLife
- VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis
- (2016) Gareth W. Fearnley et al. Biology Open
- Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?
- (2016) Yu-Ling Li et al. Cancer Biology & Medicine
- The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis
- (2015) G. A. Smith et al. BIOSCIENCE REPORTS
- The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors
- (2015) Stephen PH Alexander et al. BRITISH JOURNAL OF PHARMACOLOGY
- Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration
- (2015) Richard P. Hulse et al. CLINICAL SCIENCE
- Neuropilin Functions as an Essential Cell Surface Receptor
- (2015) Hou-Fu Guo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity
- (2015) Madelane Teran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex
- (2015) Brian G. Coon et al. JOURNAL OF CELL BIOLOGY
- Application of BRET to monitor ligand binding to GPCRs
- (2015) Leigh A Stoddart et al. NATURE METHODS
- Pathophysiology and Neuroprotection of Global and Focal Perinatal Brain Injury: Lessons From Animal Models
- (2015) Luigi Titomanlio et al. PEDIATRIC NEUROLOGY
- VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8
- (2015) Gina A. Smith et al. TRAFFIC
- Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model
- (2015) Lindsay Wendel Clegg et al. PLoS Computational Biology
- VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration
- (2015) G. W. Fearnley et al. Biology Open
- Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma
- (2014) M V Gammons et al. BRITISH JOURNAL OF CANCER
- Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax
- (2014) Sandeepa M. Eswarappa et al. CELL
- PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells
- (2014) Anthony A. Lanahan et al. CIRCULATION
- VEGF Signaling in Cancer Treatment
- (2014) Daniela Sia et al. CURRENT PHARMACEUTICAL DESIGN
- VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
- (2014) M. Tillo et al. DEVELOPMENT
- NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation
- (2014) Sina Koch et al. DEVELOPMENTAL CELL
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- (2014) Sandro Manni et al. FASEB JOURNAL
- Comparative insight into expression of recombinant human VEGF111b, a newly identified anti-angiogenic isoform, in eukaryotic cell lines
- (2014) Fariba Dehghanian et al. GENE
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- (2014) Gholamreza Azizi et al. International Journal of Rheumatic Diseases
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- (2014) K. Matsumoto et al. JOURNAL OF BIOCHEMISTRY
- VEGF-A isoforms differentially regulate ATF-2–dependent VCAM-1 gene expression and endothelial–leukocyte interactions
- (2014) Gareth W. Fearnley et al. MOLECULAR BIOLOGY OF THE CELL
- Allosteric targeting of receptor tyrosine kinases
- (2014) Frederik De Smet et al. NATURE BIOTECHNOLOGY
- An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease
- (2014) Ryosuke Kikuchi et al. NATURE MEDICINE
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- (2014) SANG WON LEE et al. ONCOLOGY REPORTS
- Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates
- (2014) M. Y. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Angiogenic response following renal ischemia reperfusion injury: new players
- (2014) N. Pallet et al. PROGRES EN UROLOGIE
- Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation
- (2014) Sandro Manni et al. STRUCTURE
- Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair
- (2014) Kelly E. Johnson et al. Advances in Wound Care
- Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation
- (2014) Helen Jopling et al. Cells
- Protocatechuic Acid Induces Angiogenesis through PI3K-Akt-eNOS-VEGF Signalling Pathway
- (2013) Zechun Kang et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- VEGF111b, a new member of VEGFxxxb isoforms and induced by mitomycin C, inhibits angiogenesis
- (2013) Fang Gu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features
- (2013) Tiina Nieminen et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Extracellular regulation of VEGF: Isoforms, proteolysis, and vascular patterning
- (2013) Prakash Vempati et al. CYTOKINE & GROWTH FACTOR REVIEWS
- The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis
- (2013) Anthony Lanahan et al. DEVELOPMENTAL CELL
- Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors
- (2013) Manuela Schmidinger EJC SUPPLEMENTS
- Essential Role for Endocytosis in the Growth Factor-stimulated Activation of ERK1/2 in Endothelial Cells
- (2013) Morgane Gourlaouen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Detection of VEGF-Axxxb Isoforms in Human Tissues
- (2013) David O. Bates et al. PLoS One
- VEGFR and Type-V RTK Activation and Signaling
- (2013) M. Shibuya Cold Spring Harbor Perspectives in Biology
- New prospects in the roles of the C-terminal domains of VEGF-A and their cooperation for ligand binding, cellular signaling and vessels formation
- (2012) Romain Delcombel et al. ANGIOGENESIS
- SRPK1 inhibitionin vivo: modulation of VEGF splicing and potential treatment for multiple diseases: Figure 1
- (2012) Sebastian Oltean et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors
- (2012) Matthew W. Parker et al. BIOCHEMISTRY
- New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2
- (2012) Terry Kenakin BRITISH JOURNAL OF PHARMACOLOGY
- VEGF-Induced Vascular Permeability Is Mediated by FAK
- (2012) Xiao Lei Chen et al. DEVELOPMENTAL CELL
- Targeting VEGF signalling via the neuropilin co-receptor
- (2012) Snezana Djordjevic et al. DRUG DISCOVERY TODAY
- Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases
- (2012) M. Shibuya JOURNAL OF BIOCHEMISTRY
- Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1
- (2012) Matthew W. Parker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites
- (2012) C. A. C. Hyde et al. MOLECULAR AND CELLULAR BIOLOGY
- Vascular Endothelial Growth Factor A in Intraocular Vascular Disease
- (2012) Joan W. Miller et al. OPHTHALMOLOGY
- Do Anti-Angiogenic VEGF (VEGFxxxb) Isoforms Exist? A Cautionary Tale
- (2012) Sheila Harris et al. PLoS One
- Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition
- (2012) Matthew W. Parker et al. PLoS One
- The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis
- (2012) Melissa J. Cudmore et al. Nature Communications
- The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling
- (2011) Helen M. Jopling et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Signal transduction by vascular endothelial growth factor receptors
- (2011) Sina Koch et al. BIOCHEMICAL JOURNAL
- Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides
- (2011) Wenjing Zhao et al. BIOSCIENCE REPORTS
- Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression
- (2011) M. Franco et al. BLOOD
- Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output
- (2011) K. Ballmer-Hofer et al. BLOOD
- Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization
- (2011) M. S. Brozzo et al. BLOOD
- Hallmarks of Cancer: The Next Generation
- (2011) Douglas Hanahan et al. CELL
- The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins
- (2011) A. Fantin et al. DEVELOPMENT
- Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering
- (2011) Kaisa Kisko et al. FASEB JOURNAL
- Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines
- (2011) Shalini Iyer et al. FEBS Journal
- Neuropilin-1 expression in cancer and development
- (2011) Adrian M Jubb et al. JOURNAL OF PATHOLOGY
- VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation
- (2011) Birger Herzog et al. MOLECULAR BIOLOGY OF THE CELL
- VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A
- (2011) Raúl Catena et al. Molecular Cancer
- VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts
- (2010) Ingrid Nilsson et al. EMBO JOURNAL
- Quantification and cell-to-cell variation of vascular endothelial growth factor receptors
- (2010) P.I. Imoukhuede et al. EXPERIMENTAL CELL RESEARCH
- Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability
- (2010) Ding Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis
- (2010) Yingdi Wang et al. NATURE
- HSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model
- (2010) Tong-Young Lee et al. PLoS One
- Structural determinants of growth factor binding and specificity by VEGF receptor 2
- (2010) V.-M. Leppanen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
- (2010) Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers
- (2009) Debora Dell'Era Dosch et al. FASEB JOURNAL
- Snake Venom Vascular Endothelial Growth Factors (VEGF-Fs) Exclusively Vary Their Structures and Functions among Species
- (2009) Yasuo Yamazaki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Diversity of VEGF-A as a Regulator of Its Biological Activity
- (2009) Jeanette Woolard et al. MICROCIRCULATION
- Endosomes: A legitimate platform for the signaling train
- (2009) J. E. Murphy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands
- (2009) Y. Cao Science Signaling
- Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis
- (2009) Alexander F. Bruns et al. TRAFFIC
- VEGF receptor protein–tyrosine kinases: Structure and regulation
- (2008) Robert Roskoski BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy
- (2008) A H R Varey et al. BRITISH JOURNAL OF CANCER
- The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice
- (2008) E S Rennel et al. BRITISH JOURNAL OF CANCER
- Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity
- (2008) H. Kawamura et al. CANCER RESEARCH
- Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1
- (2008) Claudia Prahst et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors
- (2008) D. G. Nowak et al. JOURNAL OF CELL SCIENCE
- Vascular endothelial growth factor regulates Stanniocalcin-1 expression via Neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth Factor-2
- (2007) David I.R. Holmes et al. CELLULAR SIGNALLING
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