- Home
- Publications
- Publication Search
- Publication Details
Title
Allosteric targeting of receptor tyrosine kinases
Authors
Keywords
-
Journal
NATURE BIOTECHNOLOGY
Volume 32, Issue 11, Pages 1113-1120
Publisher
Springer Nature
Online
2014-11-08
DOI
10.1038/nbt.3028
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity
- (2014) John A. Corbin et al. PLoS One
- Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling
- (2013) Corentin Herbert et al. CANCER CELL
- Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties
- (2013) Françoise Bono et al. CANCER CELL
- Impact of Quaternary Structure Dynamics on Allosteric Drug Discovery
- (2013) Eileen K. Jaffe CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Tyrosine Kinase Inhibitors: Their On-Target Toxicities as Potential Indicators of Efficacy
- (2013) Devron R. Shah et al. DRUG SAFETY
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Emerging paradigms in GPCR allostery: implications for drug discovery
- (2013) Denise Wootten et al. NATURE REVIEWS DRUG DISCOVERY
- Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation
- (2013) V.-M. Leppanen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Allosteric Regulation of PKM2 Allows Cellular Adaptation to Different Physiological States
- (2013) D. Y. Gui et al. Science Signaling
- The Growing Arsenal of ATP-Competitive and Allosteric Inhibitors of BCR-ABL
- (2012) O. Hantschel et al. CANCER RESEARCH
- Inhibitors of the TAM subfamily of tyrosine kinases: Synthesis and biological evaluation
- (2012) Rosa M. Suárez et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites
- (2012) C. A. C. Hyde et al. MOLECULAR AND CELLULAR BIOLOGY
- Serine is a natural ligand and allosteric activator of pyruvate kinase M2
- (2012) Barbara Chaneton et al. NATURE
- Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors
- (2012) M. McTigue et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rational Engineering of Enzyme Allosteric Regulation through Sequence Evolution Analysis
- (2012) Jae-Seong Yang et al. PLoS Computational Biology
- Allosteric Communication across the Native and Mutated KIT Receptor Tyrosine Kinase
- (2012) Elodie Laine et al. PLoS Computational Biology
- Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis
- (2011) Florian Grebien et al. CELL
- Crystal Structure and Allosteric Activation of Protein Kinase C βII
- (2011) Thomas A. Leonard et al. CELL
- Allosteric modulation by protein kinase Cε leads to modified responses of EGF receptor towards tyrosine kinase inhibitors
- (2011) Simona Weisheit et al. CELLULAR SIGNALLING
- Regulation of the catalytic activity of the EGF receptor
- (2011) Nicholas F Endres et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery
- (2011) Bruce J. Melancon et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear hormone receptors: Allosteric switches
- (2011) Iain J. McEwan MOLECULAR AND CELLULAR ENDOCRINOLOGY
- Catalytic Control in the EGF Receptor and Its Connection to General Kinase Regulatory Mechanisms
- (2011) Natalia Jura et al. MOLECULAR CELL
- An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo
- (2010) Craig Cherrin et al. CANCER BIOLOGY & THERAPY
- Effective Suppression of Vascular Network Formation by Combination of Antibodies Blocking VEGFR Ligand Binding and Receptor Dimerization
- (2010) Denis Tvorogov et al. CANCER CELL
- Cell Signaling by Receptor Tyrosine Kinases
- (2010) Mark A. Lemmon et al. CELL
- PKCε acts as negative allosteric modulator of EGF receptor signalling
- (2010) Simona Weisheit et al. CELLULAR SIGNALLING
- Allosteric Peptide Activators of Pro-Hepatocyte Growth Factor Stimulate Met Signaling
- (2010) Kyle E. Landgraf et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
- (2010) Jianming Zhang et al. NATURE
- Cyclotraxin-B, the First Highly Potent and Selective TrkB Inhibitor, Has Anxiolytic Properties in Mice
- (2010) Maxime Cazorla et al. PLoS One
- Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling
- (2010) Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Receptor tyrosine kinase transmembrane domains
- (2010) Edwin Li et al. Cell Adhesion & Migration
- Structure–function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling
- (2009) Felix S. Grünewald et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- The Intracellular Juxtamembrane Domain of the Epidermal Growth Factor (EGF) Receptor Is Responsible for the Allosteric Regulation of EGF Binding
- (2009) Jennifer L. Macdonald-Obermann et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Minireview: Not Picking Pockets: Nuclear Receptor Alternate-Site Modulators (NRAMs)
- (2009) Terry W. Moore et al. MOLECULAR ENDOCRINOLOGY
- A Molecular View of Anti-ErbB Monoclonal Antibody Therapy
- (2008) Daniel J. Leahy CANCER CELL
- A Peptoid “Antibody Surrogate” That Antagonizes VEGF Receptor 2 Activity
- (2008) D. Gomika Udugamasooriya et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- A quantitative analysis of kinase inhibitor selectivity
- (2008) Mazen W Karaman et al. NATURE BIOTECHNOLOGY
- Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
- (2008) P. Jeffrey Conn et al. NATURE REVIEWS DRUG DISCOVERY
- Contacts between membrane proximal regions of the PDGF receptor ectodomain are required for receptor activation but not for receptor dimerization
- (2008) Y. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Non-canonical fibroblast growth factor signalling in angiogenesis
- (2007) M. Murakami et al. CARDIOVASCULAR RESEARCH
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started