Mechanisms and regulation of endothelial VEGF receptor signalling

Endothelial cell-derived semaphorin 3A inhibits filopodia formation by blood vascular tip cells

(2016) Alexandra M. Ochsenbein et al.   DEVELOPMENT

Predictive Value of the sFlt-1:PlGF Ratio in Women with Suspected Preeclampsia

(2016) Harald Zeisler et al.   NEW ENGLAND JOURNAL OF MEDICINE

VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread

(2016) Xiujuan Li et al.   Nature Communications

VEGFR-2 conformational switch in response to ligand binding

(2016) Sarvenaz Sarabipour et al.   eLife

β3Integrin Promotes Long-Lasting Activation and Polarization of Vascular Endothelial Growth Factor Receptor 2 by Immobilized LigandSignificance

(2015) Cosetta Ravelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Regulation of Vascular Endothelial Growth Factor Receptor Function in Angiogenesis by Numb and Numb-LikeSignficance

(2015) Max van Lessen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

(2015) Deepitha Selvaraj et al.   CANCER CELL

Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits NeovascularizationCLINICAL PERSPECTIVE

(2015) Alexandre Dubrac et al.   CIRCULATION

Molecular Controls of Arterial Morphogenesis

(2015) M. Simons et al.   CIRCULATION RESEARCH

Neuropilin 1 balances  8 integrin-activated TGF  signaling to control sprouting angiogenesis in the brain

(2015) S. Hirota et al.   DEVELOPMENT

Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice

(2015) D. M. Barry et al.   DEVELOPMENT

mafbais a downstream transcriptional effector of Vegfc signaling essential for embryonic lymphangiogenesis in zebrafish

(2015) Katarzyna Koltowska et al.   GENES & DEVELOPMENT

ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation

(2015) Olga Tornavaca et al.   JOURNAL OF CELL BIOLOGY

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

(2015) Brian G. Coon et al.   JOURNAL OF CELL BIOLOGY

P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

(2015) ShengPeng Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin

(2015) Maike Frye et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

(2015) Sabu Abraham et al.   Nature Communications

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Relaxin inhibits cardiac fibrosis and endothelial–mesenchymal transition via the Notch pathway

(2015) Xi Zhou et al.   Drug Design Development and Therapy

Vascular Endothelial Growth Factor Receptor 3 Controls Neural Stem Cell Activation in Mice and Humans

(2015) Jinah Han et al.   Cell Reports

Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point

(2015) Nicolas Baeyens et al.   eLife

Receptor Tyrosine Kinases Endocytosis in Endothelium

(2014) Xi Zhang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glycaemic control improves perfusion recovery and VEGFR2 protein expression in diabetic mice following experimental PAD

(2014) Ayotunde O. Dokun et al.   CARDIOVASCULAR RESEARCH

Neurons Limit Angiogenesis by Titrating VEGF in Retina

(2014) Keisuke Okabe et al.   CELL

Phosphatases and kinases as regulators of the endothelial barrier function

(2014) Verena Küppers et al.   CELL AND TISSUE RESEARCH

PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

(2014) Anthony A. Lanahan et al.   CIRCULATION

Pulmonary Lymphangiectasia Resulting From Vascular Endothelial Growth Factor-C Overexpression During a Critical Period

(2014) Li-Chin Yao et al.   CIRCULATION RESEARCH

VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain

(2014) M. Tillo et al.   DEVELOPMENT

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

(2014) A. Fantin et al.   DEVELOPMENT

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

(2014) Sina Koch et al.   DEVELOPMENTAL CELL

Differential Apicobasal VEGF Signaling at Vascular Blood-Neural Barriers

(2014) Natalie Hudson et al.   DEVELOPMENTAL CELL

Angiopoietin-2 Secretion by Endothelial Cell Exosomes

(2014) Rong Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin Regulation of Angiogenesis, Arteriogenesis, and Vascular Permeability

(2014) Alice Plein et al.   MICROCIRCULATION

Protein interaction switches coordinate Raf-1 and MST2/Hippo signalling

(2014) David Romano et al.   NATURE CELL BIOLOGY

The docking protein FRS2  is a critical regulator of VEGF receptors signaling

(2014) P.-Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Principles for the Therapeutic Exploitation of Glycosylation

(2014) Martin Dalziel et al.   SCIENCE

Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function

(2014) X. Liu et al.   Science Signaling

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

(2014) Maria V Gelfand et al.   eLife

LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking

(2013) Fengyan Jin et al.   ANGIOGENESIS

Genetic Reduction of Vascular Endothelial Growth Factor Receptor 2 Rescues Aberrant Angiogenesis Caused by Epsin Deficiency

(2013) Kandice L. Tessneer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Early VEGFR2 activation in response to flow is VEGF-dependent and mediated by MMP activity

(2013) Nathaniel G. dela Paz et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ETS Factors Regulate Vegf-Dependent Arterial Specification

(2013) Joshua D. Wythe et al.   DEVELOPMENTAL CELL

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis

(2013) Alan C. Rapraeger et al.   FEBS Journal

Hippo signaling components, Mst1 and Mst2, act as a switch between self-renewal and differentiation in Xenopus hematopoietic and endothelial progenitors

(2013) Susumu Nejigane et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Phosphorylation of Angiomotin by Lats1/2 Kinases Inhibits F-actin Binding, Cell Migration, and Angiogenesis

(2013) Xiaoming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lactate Engages Receptor Tyrosine Kinases Axl, Tie2, and Vascular Endothelial Growth Factor Receptor 2 to Activate Phosphoinositide 3-Kinase/Akt and Promote Angiogenesis

(2013) Guo-Xiang Ruan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetraspanin CD63 Promotes Vascular Endothelial Growth Factor Receptor 2-β1 Integrin Complex Formation, Thereby Regulating Activation and Downstream Signaling in Endothelial Cellsin Vitroandin Vivo

(2013) Sònia Tugues et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial ERK signaling controls lymphatic fate specification

(2013) Yong Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Spatial regulation of VEGF receptor endocytosis in angiogenesis

(2013) Masanori Nakayama et al.   NATURE CELL BIOLOGY

Resolving Molecular Events in the Regulation of Meiosis in Male and Female Germ Cells

(2013) S. Kumar et al.   Science Signaling

The Basis for the Distinct Biological Activities of Vascular Endothelial Growth Factor Receptor-1 Ligands

(2013) A. Anisimov et al.   Science Signaling

VEGFR and Type-V RTK Activation and Signaling

(2013) M. Shibuya   Cold Spring Harbor Perspectives in Biology

VE-PTP regulates VEGFR2 activity in stalk cells to establish endothelial cell polarity and lumen formation

(2013) Makoto Hayashi et al.   Nature Communications

The myosin motor Myo1c is required for VEGFR2 delivery to the cell surface and for angiogenic signaling

(2012) Ajit Tiwari et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Binding and neutralization of vascular endothelial growth factor (VEGF) and related ligands by VEGF Trap, ranibizumab and bevacizumab

(2012) Nicholas Papadopoulos et al.   ANGIOGENESIS

Regulation of endothelial and hematopoietic development by the ETS transcription factor Etv2

(2012) Kelly Lammerts van Bueren et al.   CURRENT OPINION IN HEMATOLOGY

Chemokine Signaling Directs Trunk Lymphatic Network Formation along the Preexisting Blood Vasculature

(2012) Young Ryun Cha et al.   DEVELOPMENTAL CELL

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

(2012) Konstantin Gaengel et al.   DEVELOPMENTAL CELL

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway

(2012) Bruno Larrivée et al.   DEVELOPMENTAL CELL

Axl is essential for VEGF-A-dependent activation of PI3K/Akt

(2012) Guo-Xiang Ruan et al.   EMBO JOURNAL

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

(2012) M. Shibuya   JOURNAL OF BIOCHEMISTRY

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of shear-stress-induced VEGF expression in endothelial cell survival

(2012) Nathaniel G. dela Paz et al.   JOURNAL OF CELL SCIENCE

Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling

(2012) Satish Pasula et al.   JOURNAL OF CLINICAL INVESTIGATION

SCFβ-TRCPsuppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2

(2012) Shavali Shaik et al.   JOURNAL OF EXPERIMENTAL MEDICINE

VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

(2012) Zuyue Sun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of Targets of c-Src Tyrosine Kinase by Chemical Complementation and Phosphoproteomics

(2012) Isabel Martinez Ferrando et al.   MOLECULAR & CELLULAR PROTEOMICS

Cardiac angiogenic imbalance leads to peripartum cardiomyopathy

(2012) Ian S. Patten et al.   NATURE

Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF–VEGFR2 signalling

(2012) Rui Benedito et al.   NATURE

ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1

(2012) Inbal Avraham-Davidi et al.   NATURE MEDICINE

An Inside View: VEGF Receptor Trafficking and Signaling

(2012) Michael Simons   PHYSIOLOGY

Integrin β3 Crosstalk with VEGFR Accommodating Tyrosine Phosphorylation as a Regulatory Switch

(2012) Xiaoxia Z. West et al.   PLoS One

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

(2012) Melissa J. Cudmore et al.   Nature Communications

Crosstalk and Signaling Switches in Mitogen-Activated Protein Kinase Cascades

(2012) Dirk Fey et al.   Frontiers in Physiology

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins

(2011) A. Fantin et al.   DEVELOPMENT

VEGF signalling controls GnRH neuron survival via NRP1 independently of KDR and blood vessels

(2011) A. Cariboni et al.   DEVELOPMENT

Mechanoinduction of lymph vessel expansion

(2011) Lara Planas-Paz et al.   EMBO JOURNAL

Galectin-3 Protein Modulates Cell Surface Expression and Activation of Vascular Endothelial Growth Factor Receptor 2 in Human Endothelial Cells

(2011) Anna I. Markowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF-dependent regulation of VEGF receptor 2 expression in mice

(2011) Masahiro Murakami et al.   JOURNAL OF CLINICAL INVESTIGATION

PEST Motif Serine and Tyrosine Phosphorylation Controls Vascular Endothelial Growth Factor Receptor 2 Stability and Downregulation

(2011) R. D. Meyer et al.   MOLECULAR AND CELLULAR BIOLOGY

VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling

(2011) Tuomas Tammela et al.   NATURE CELL BIOLOGY

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanism and physiological functions of clathrin-mediated endocytosis

(2011) Harvey T. McMahon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

c-Cbl inhibits angiogenesis and tumor growth by suppressing activation of PLCγ1

(2011) R D Meyer et al.   ONCOGENE

Protein Tyrosine Phosphatase PTPN14 Is a Regulator of Lymphatic Function and Choanal Development in Humans

(2010) Audrey C. Au et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Akt/Protein Kinase B Is Required for Lymphatic Network Formation, Remodeling, and Valve Development

(2010) Fei Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

RhoJ/TCL Regulates Endothelial Motility and Tube Formation and Modulates Actomyosin Contractility and Focal Adhesion Numbers

(2010) Sukhbir Kaur et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gremlin is a novel agonist of the major proangiogenic receptor VEGFR2

(2010) S. Mitola et al.   BLOOD

Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6

(2010) V. Manickam et al.   BLOOD

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

VEGF Receptor 2 Endocytic Trafficking Regulates Arterial Morphogenesis

(2010) Anthony A. Lanahan et al.   DEVELOPMENTAL CELL

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

(2010) Ingrid Nilsson et al.   EMBO JOURNAL

Glucose Intolerance and Impaired Insulin Secretion in Pancreas-Specific Signal Transducer and Activator of Transcription-3 Knockout Mice Are Associated with Microvascular Alterations in the Pancreas

(2010) Elena Kostromina et al.   ENDOCRINOLOGY

Quantification and cell-to-cell variation of vascular endothelial growth factor receptors

(2010) P.I. Imoukhuede et al.   EXPERIMENTAL CELL RESEARCH

Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells

(2010) Tom T. Chen et al.   JOURNAL OF CELL BIOLOGY

ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish

(2010) Bin Ren et al.   JOURNAL OF CLINICAL INVESTIGATION

Binding to the Extracellular Matrix and Proteolytic Processing: Two Key Mechanisms Regulating Vascular Endothelial Growth Factor Action

(2010) Napoleone Ferrara   MOLECULAR BIOLOGY OF THE CELL

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

(2010) Suphansa Sawamiphak et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

In control at the ER: PTP1B and the down-regulation of RTKs by dephosphorylation and endocytosis

(2010) Matthew Stuible et al.   TRENDS IN CELL BIOLOGY

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

(2009) Tomomi Masumura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Structure–function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling

(2009) Felix S. Grünewald et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis

(2009) G. Wei et al.   BLOOD

Purinergic regulation of vascular endothelial growth factor signaling in angiogenesis

(2009) S M Rumjahn et al.   BRITISH JOURNAL OF CANCER

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress-induced angiogenesis

(2009) Eric Gee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Neuropilin-1 in regulation of VEGF-induced activation of p38MAPK and endothelial cell organization

(2008) H. Kawamura et al.   BLOOD

Targeted Deletion of the Calcineurin Inhibitor DSCR1 Suppresses Tumor Growth

(2008) Sandra Ryeom et al.   CANCER CELL

Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity

(2008) H. Kawamura et al.   CANCER RESEARCH

Combinatorial Regulation of Endothelial Gene Expression by Ets and Forkhead Transcription Factors

(2008) Sarah De Val et al.   CELL

Fibroblast growth factor regulation of neovascularization

(2008) Masahiro Murakami et al.   CURRENT OPINION IN HEMATOLOGY

Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos

(2008) E. A. V. Jones et al.   DEVELOPMENT

An essential role for Rac1 in endothelial cell function and vascular development

(2008) Wenfu Tan et al.   FASEB JOURNAL

Mechanotransduction in an extracted cell model: Fyn drives stretch- and flow-elicited PECAM-1 phosphorylation

(2008) Yi-Jen Chiu et al.   JOURNAL OF CELL BIOLOGY

The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling

(2008) E. Mattila et al.   JOURNAL OF CELL SCIENCE

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

(2008) Mariona Graupera et al.   NATURE

Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts

(2008) Pipsa Saharinen et al.   NATURE CELL BIOLOGY

Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma

(2008) Masatoshi Jinnin et al.   NATURE MEDICINE

Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7

(2008) S. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA