Neuropilin Functions as an Essential Cell Surface Receptor

Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling

(2015) Juan-Juan Ou et al.   CANCER LETTERS

Full-Length Semaphorin-3C Is an Inhibitor of Tumor Lymphangiogenesis and Metastasis

(2015) Yelena Mumblat et al.   CANCER RESEARCH

Circulating Soluble Neuropilin-1 in Patients with Early Cervical Cancer and Cervical Intraepithelial Neoplasia Can Be Used as a Valuable Diagnostic Biomarker

(2015) Shouhua Yang et al.   DISEASE MARKERS

Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

(2015) Tim S. Ellison et al.   Disease Models & Mechanisms

Semaphorin-3C signals through Neuropilin-1 and PlexinD1 receptors to inhibit pathological angiogenesis

(2015) W.-J. Yang et al.   EMBO Molecular Medicine

Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity

(2015) Madelane Teran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GPNMB cooperates with neuropilin-1 to promote mammary tumor growth and engages integrin α5β1 for efficient breast cancer metastasis

(2015) G Maric et al.   ONCOGENE

Structural Basis for VEGF-C Binding to Neuropilin-2 and Sequestration by a Soluble Splice Form

(2015) Matthew W. Parker et al.   STRUCTURE

Splicing and Proteolytic Processing in VEGF Signaling: Now It Is the Coreceptor’s Turn

(2015) Xiaolan Yao et al.   STRUCTURE

Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells

(2015) Hong-Bo Wang et al.   Nature Communications

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

Regulation of mTOR Signaling by Semaphorin 3F-Neuropilin 2 Interactions In Vitro and In Vivo

(2015) Hironao Nakayama et al.   Scientific Reports

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

(2014) Sina Koch et al.   DEVELOPMENTAL CELL

Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1–dependent ABL1 activation in endothelial cells

(2014) Claudio Raimondi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability

(2014) Hong-Bo Pang et al.   Nature Communications

Lack of cardiac and high-fat diet induced metabolic phenotypes in two independent strains of Vegf-b knockout mice

(2014) M. H. Dijkstra et al.   Scientific Reports

Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells

(2014) Hira Lal Goel et al.   Cell Reports

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

(2014) Maria V Gelfand et al.   eLife

Characterisation of the interaction of neuropilin-1 with heparin and a heparan sulfate mimetic library of heparin-derived sugars

(2014) Katarzyna A. Uniewicz et al.   PeerJ

Mechanistic Basis for the Potent Anti-Angiogenic Activity of Semaphorin 3F

(2013) Hou-Fu Guo et al.   BIOCHEMISTRY

NRP1 acts cell autonomously in endothelium to promote tip cell function during sprouting angiogenesis

(2013) A. Fantin et al.   BLOOD

Neuropilin-2 Promotes Extravasation and Metastasis by Interacting with Endothelial  5 Integrin

(2013) Y. Cao et al.   CANCER RESEARCH

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

(2013) Hira Lal Goel et al.   EMBO Molecular Medicine

The cytoplasmic domain of neuropilin-1 regulates focal adhesion turnover

(2013) Himabindu Reddy Seerapu et al.   FEBS LETTERS

Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer

(2013) Carolyn A Staton et al.   HISTOPATHOLOGY

Effect of C-Terminal Sequence on Competitive Semaphorin Binding to Neuropilin-1

(2013) Matthew W. Parker et al.   JOURNAL OF MOLECULAR BIOLOGY

Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma

(2013) Melanie G. Hayden Gephart et al.   JOURNAL OF NEURO-ONCOLOGY

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Expression of VEGF and Semaphorin Genes Define Subgroups of Triple Negative Breast Cancer

(2013) R. Joseph Bender et al.   PLoS One

Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors

(2012) Matthew W. Parker et al.   BIOCHEMISTRY

Abstract 4047: Introducing a novel acoustic imaging tool for breast cancer detection

(2012) Azra Alizad et al.   CANCER RESEARCH

Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions

(2012) Prasanta K. Hota et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin-2 regulates  6 1 integrin in the formation of focal adhesions and signaling

(2012) H. L. Goel et al.   JOURNAL OF CELL SCIENCE

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

(2012) Carolina E. Hagberg et al.   NATURE

Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex

(2012) Bert J C Janssen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

(2012) Matthew W. Parker et al.   PLoS One

SEMA3A, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome

(2012) Naresh Kumar Hanchate et al.   PLoS Genetics

The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins

(2011) A. Fantin et al.   DEVELOPMENT

Semaphorin Signals on the Road of Endothelial Tip Cells

(2011) Luca Tamagnone et al.   DEVELOPMENTAL CELL

Neuropilins are positive regulators of Hedgehog signal transduction

(2011) R. T. Hillman et al.   GENES & DEVELOPMENT

Neuropilin-1 Signaling through p130Cas Tyrosine Phosphorylation Is Essential for Growth Factor-Dependent Migration of Glioma and Endothelial Cells

(2011) I. M. Evans et al.   MOLECULAR AND CELLULAR BIOLOGY

Furin Processing of Semaphorin 3F Determines Its Anti-Angiogenic Activity by Regulating Direct Binding and Competition for Neuropilin

(2010) Matthew W. Parker et al.   BIOCHEMISTRY

Exogenous Recombinant Dimeric Neuropilin-1 Is Sufficient to Drive Angiogenesis

(2010) Katarzyna A. Uniewicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

A Forward Genetic Screen in Mice Identifies Sema3AK108N, which Binds to Neuropilin-1 but Cannot Signal

(2010) J. Merte et al.   JOURNAL OF NEUROSCIENCE

HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165

(2009) S. Lambert et al.   BLOOD

αvβ3 Integrin Limits the Contribution of Neuropilin-1 to Vascular Endothelial Growth Factor-induced Angiogenesis

(2009) Stephen D. Robinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilin-1/GIPC1 Signaling Regulates α5β1 Integrin Traffic and Function in Endothelial Cells

(2009) Donatella Valdembri et al.   PLOS BIOLOGY

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Neuropilin-1 Upholds Dedifferentiation and Propagation Phenotypes of Renal Cell Carcinoma Cells by Activating Akt and Sonic Hedgehog Axes

(2008) Ying Cao et al.   CANCER RESEARCH

VEGF-A Stimulates ADAM17-Dependent Shedding of VEGFR2 and Crosstalk Between VEGFR2 and ERK Signaling

(2008) Steven Swendeman et al.   CIRCULATION RESEARCH

Separating genetic and hemodynamic defects in neuropilin 1 knockout embryos

(2008) E. A. V. Jones et al.   DEVELOPMENT

Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1

(2008) Claudia Prahst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY