Architecture and hydration of the arginine-binding site of neuropilin-1

NRPa-308, a new neuropilin-1 antagonist, exerts in vitro anti-angiogenic and anti-proliferative effects and in vivo anti-cancer effects in a mouse xenograft model

(2018) Wang-Qing Liu et al.   CANCER LETTERS

Conformational latitude - activity relationship of KPPR tetrapeptide analogues toward their ability to inhibit binding of vascular endothelial growth factor 165 to neuropilin-1

(2017) Bartlomiej Fedorczyk et al.   JOURNAL OF PEPTIDE SCIENCE

Structure-activity relationship study of tetrapeptide inhibitors of the Vascular Endothelial Growth Factor A binding to Neuropilin-1

(2017) Dagmara Tymecka et al.   PEPTIDES

Carbohydrate-based peptidomimetics targeting neuropilin-1: Synthesis, molecular docking study and in vitro biological activities

(2016) Mylène Richard et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ablation of Neuropilin 1 from glioma-associated microglia and macrophages slows tumor progression

(2016) Jeremy T. Miyauchi et al.   Oncotarget

Immunoglobulin Fc-fused, neuropilin-1-specific peptide shows efficient tumor tissue penetration and inhibits tumor growth via anti-angiogenesis

(2015) Ye-Jin Kim et al.   JOURNAL OF CONTROLLED RELEASE

Neuropilins are multifunctional coreceptors involved in tumor initiation, growth, metastasis and immunity

(2015) Gerald J Prud'homme et al.   Oncotarget

Discovery of novel inhibitors of vascular endothelial growth factor-A–Neuropilin-1 interaction by structure-based virtual screening

(2014) Anna Starzec et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based discovery of a small non-peptidic Neuropilins antagonist exerting in vitro and in vivo anti-tumor activity on breast cancer model

(2014) Lucia Borriello et al.   CANCER LETTERS

N-Terminal Modification of VEGF-A C Terminus-Derived Peptides Delineates Structural Features Involved in Neuropilin-1 Binding and Functional Activity

(2014) Haiyan Jia et al.   CHEMBIOCHEM

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis

(2014) A. Fantin et al.   DEVELOPMENT

Design of a Cyclotide Antagonist of Neuropilin-1 and -2 That Potently Inhibits Endothelial Cell Migration

(2013) Jennifer A. Getz et al.   ACS Chemical Biology

Hydration Properties of Ligands and Drugs in Protein Binding Sites: Tightly-Bound, Bridging Water Molecules and Their Effects and Consequences on Molecular Design Strategies

(2013) Alfonso T. García-Sosa   Journal of Chemical Information and Modeling

Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis

(2013) Greg M. Delgoffe et al.   NATURE

Neuropilin 1 guides regulatory T cells into VEGF-producing melanoma

(2013) Wiebke Hansen   OncoImmunology

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapid and Accurate Prediction and Scoring of Water Molecules in Protein Binding Sites

(2012) Gregory A. Ross et al.   PLoS One

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neuropilins are positive regulators of Hedgehog signal transduction

(2011) R. T. Hillman et al.   GENES & DEVELOPMENT

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1

(2010) Alexandre Novoa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Neuropilin-1 antagonism in human carcinoma cells inhibits migration and enhances chemosensitivity

(2010) H Jia et al.   BRITISH JOURNAL OF CANCER

Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-β signaling in hepatic stellate cells

(2010) Sheng Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Small Molecule Inhibitors of the Neuropilin-1 Vascular Endothelial Growth Factor A (VEGF-A) Interaction

(2010) Ashley Jarvis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Calculation of Local Water Densities in Biological Systems: A Comparison of Molecular Dynamics Simulations and the 3D-RISM-KH Molecular Theory of Solvation

(2010) Martin C. Stumpe et al.   JOURNAL OF PHYSICAL CHEMISTRY B

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Energetics of Displacing Water Molecules from Protein Binding Sites: Consequences for Ligand Optimization

(2009) Julien Michel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration

(2009) T. Teesalu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropilins: structure, function and role in disease

(2008) Caroline Pellet-Many et al.   BIOCHEMICAL JOURNAL

Neuropilin-1 is a receptor for transforming growth factor β-1, activates its latent form, and promotes regulatory T cell activity

(2008) Yelena Glinka et al.   JOURNAL OF LEUKOCYTE BIOLOGY