Molecular Pharmacology of VEGF-A Isoforms: Binding and Signalling at VEGFR2

Characterization of a drug-targetable allosteric site regulating vascular endothelial growth factor signaling

(2018) Katherine M. Thieltges et al.   ANGIOGENESIS

Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease

(2018) Yohei Shibata et al.   CLINICA CHIMICA ACTA

Architecture and hydration of the arginine-binding site of neuropilin-1

(2018) Filipa Mota et al.   FEBS Journal

Expression of vascular endothelial growth factor A isoforms is dysregulated in women with endometriosis

(2018) Kevin Danastas et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

NanoBRET Approaches to Study Ligand Binding to GPCRs and RTKs

(2018) Leigh A. Stoddart et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Modulation of VEGF-A Alternative Splicing as a Novel Treatment in Chronic Kidney Disease

(2018) et al.   Genes

Effects of 4 multitargeted receptor tyrosine kinase inhibitors on regional hemodynamics in conscious, freely moving rats

(2017) Joanne J. Carter et al.   FASEB JOURNAL

The Different Effects of VEGFA121 and VEGFA165 on Regulating Angiogenesis Depend on Phosphorylation Sites of VEGFR2

(2017) Wang Shiying et al.   INFLAMMATORY BOWEL DISEASES

Chemotherapy induces alternative transcription and splicing: Facts and hopes for cancer treatment

(2017) Charles A. Lambert et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

VEGF and the diabetic kidney: More than too much of a good thing

(2017) Syamantak Majumder et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A

(2017) Sandra Markovic-Mueller et al.   STRUCTURE

Direct Effects of Anti-Angiogenic Therapies on Tumor Cells: VEGF Signaling

(2017) Thomas Simon et al.   TRENDS IN MOLECULAR MEDICINE

VEGF-A121a binding to Neuropilins – A concept revisited

(2017) Sarvenaz Sarabipour et al.   Cell Adhesion & Migration

Dynamics and implications of circulating anti-angiogenic VEGF-A165b isoform in patients with ST-elevation myocardial infarction

(2017) Luisa Hueso et al.   Scientific Reports

A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands

(2017) Lindsay E. Clegg et al.   PLoS Computational Biology

Structure analyses reveal a regulated oligomerization mechanism of the PlexinD1/GIPC/myosin VI complex

(2017) Guijun Shang et al.   eLife

RNA-Sequencing data supports the existence of novel VEGFA splicing events but not of VEGFAxxxb isoforms

(2017) Stephen Bridgett et al.   Scientific Reports

Dynasore impairs VEGFR2 signalling in an endocytosis-independent manner

(2017) Dimitris Basagiannis et al.   Scientific Reports

Evidence for Pro-angiogenic Functions of VEGF-Ax

(2016) Hong Xin et al.   CELL

Diabetic macular oedema: pathophysiology, management challenges and treatment resistance

(2016) Bobak Bahrami et al.   DIABETOLOGIA

Constitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding

(2016) Dimitris Basagiannis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

VEGF induces signalling and angiogenesis by directing VEGFR2 internalisation via macropinocytosis.

(2016) Dimitris Basagiannis et al.   JOURNAL OF CELL SCIENCE

Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma

(2016) Xi Ye et al.   JOURNAL OF PATHOLOGY

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting VEGF in eye neovascularization: What's new?

(2016) Marialaura Amadio et al.   PHARMACOLOGICAL RESEARCH

Resistance to anti-VEGF therapy in neovascular age-related macular degeneration: a comprehensive review

(2016) Xiaodong Sun et al.   Drug Design Development and Therapy

Targeting the pro-angiogenic forms of VEGF or inhibiting their expression as anti-cancer strategies

(2016) Mélanie Guyot et al.   Oncotarget

VEGFR-2 conformational switch in response to ligand binding

(2016) Sarvenaz Sarabipour et al.   eLife

VEGF-A isoforms program differential VEGFR2 signal transduction, trafficking and proteolysis

(2016) Gareth W. Fearnley et al.   Biology Open

Relationship of VEGF/VEGFR with immune and cancer cells: staggering or forward?

(2016) Yu-Ling Li et al.   Cancer Biology & Medicine

The cellular response to vascular endothelial growth factors requires co-ordinated signal transduction, trafficking and proteolysis

(2015) G. A. Smith et al.   BIOSCIENCE REPORTS

The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors

(2015) Stephen PH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Vascular endothelial growth factor-A165b prevents diabetic neuropathic pain and sensory neuronal degeneration

(2015) Richard P. Hulse et al.   CLINICAL SCIENCE

Neuropilin Functions as an Essential Cell Surface Receptor

(2015) Hou-Fu Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Binding of Vascular Endothelial Growth Factor-A and Its Receptors to Heparin Selectively Modulates Complex Affinity

(2015) Madelane Teran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intramembrane binding of VE-cadherin to VEGFR2 and VEGFR3 assembles the endothelial mechanosensory complex

(2015) Brian G. Coon et al.   JOURNAL OF CELL BIOLOGY

Application of BRET to monitor ligand binding to GPCRs

(2015) Leigh A Stoddart et al.   NATURE METHODS

Pathophysiology and Neuroprotection of Global and Focal Perinatal Brain Injury: Lessons From Animal Models

(2015) Luigi Titomanlio et al.   PEDIATRIC NEUROLOGY

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8

(2015) Gina A. Smith et al.   TRAFFIC

Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model

(2015) Lindsay Wendel Clegg et al.   PLoS Computational Biology

VEGF-A isoform-specific regulation of calcium ion flux, transcriptional activation and endothelial cell migration

(2015) G. W. Fearnley et al.   Biology Open

Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma

(2014) M V Gammons et al.   BRITISH JOURNAL OF CANCER

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

(2014) Sandeepa M. Eswarappa et al.   CELL

PTP1b Is a Physiologic Regulator of Vascular Endothelial Growth Factor Signaling in Endothelial Cells

(2014) Anthony A. Lanahan et al.   CIRCULATION

VEGF Signaling in Cancer Treatment

(2014) Daniela Sia et al.   CURRENT PHARMACEUTICAL DESIGN

VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain

(2014) M. Tillo et al.   DEVELOPMENT

NRP1 Presented in trans to the Endothelium Arrests VEGFR2 Endocytosis, Preventing Angiogenic Signaling and Tumor Initiation

(2014) Sina Koch et al.   DEVELOPMENTAL CELL

Functional and structural characterization of the kinase insert and the carboxy terminal domain in VEGF receptor 2 activation

(2014) Sandro Manni et al.   FASEB JOURNAL

Comparative insight into expression of recombinant human VEGF111b, a newly identified anti-angiogenic isoform, in eukaryotic cell lines

(2014) Fariba Dehghanian et al.   GENE

The potential role of angiogenic factors in rheumatoid arthritis

(2014) Gholamreza Azizi et al.   International Journal of Rheumatic Diseases

Roles of VEGF-A signalling in development, regeneration, and tumours

(2014) K. Matsumoto et al.   JOURNAL OF BIOCHEMISTRY

VEGF-A isoforms differentially regulate ATF-2–dependent VCAM-1 gene expression and endothelial–leukocyte interactions

(2014) Gareth W. Fearnley et al.   MOLECULAR BIOLOGY OF THE CELL

Allosteric targeting of receptor tyrosine kinases

(2014) Frederik De Smet et al.   NATURE BIOTECHNOLOGY

An antiangiogenic isoform of VEGF-A contributes to impaired vascularization in peripheral artery disease

(2014) Ryosuke Kikuchi et al.   NATURE MEDICINE

NRP-1 expression is strongly associated with the progression of pituitary adenomas

(2014) SANG WON LEE et al.   ONCOLOGY REPORTS

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

(2014) M. Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiogenic response following renal ischemia reperfusion injury: new players

(2014) N. Pallet et al.   PROGRES EN UROLOGIE

Structural and Functional Characterization of Alternative Transmembrane Domain Conformations in VEGF Receptor 2 Activation

(2014) Sandro Manni et al.   STRUCTURE

Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair

(2014) Kelly E. Johnson et al.   Advances in Wound Care

Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation

(2014) Helen Jopling et al.   Cells

Protocatechuic Acid Induces Angiogenesis through PI3K-Akt-eNOS-VEGF Signalling Pathway

(2013) Zechun Kang et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

VEGF111b, a new member of VEGFxxxb isoforms and induced by mitomycin C, inhibits angiogenesis

(2013) Fang Gu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The impact of the receptor binding profiles of the vascular endothelial growth factors on their angiogenic features

(2013) Tiina Nieminen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Extracellular regulation of VEGF: Isoforms, proteolysis, and vascular patterning

(2013) Prakash Vempati et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The Neuropilin 1 Cytoplasmic Domain Is Required for VEGF-A-Dependent Arteriogenesis

(2013) Anthony Lanahan et al.   DEVELOPMENTAL CELL

Understanding and managing toxicities of vascular endothelial growth factor (VEGF) inhibitors

(2013) Manuela Schmidinger   EJC SUPPLEMENTS

Essential Role for Endocytosis in the Growth Factor-stimulated Activation of ERK1/2 in Endothelial Cells

(2013) Morgane Gourlaouen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Detection of VEGF-Axxxb Isoforms in Human Tissues

(2013) David O. Bates et al.   PLoS One

VEGFR and Type-V RTK Activation and Signaling

(2013) M. Shibuya   Cold Spring Harbor Perspectives in Biology

New prospects in the roles of the C-terminal domains of VEGF-A and their cooperation for ligand binding, cellular signaling and vessels formation

(2012) Romain Delcombel et al.   ANGIOGENESIS

SRPK1 inhibitionin vivo: modulation of VEGF splicing and potential treatment for multiple diseases: Figure 1

(2012) Sebastian Oltean et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Function of Members of the Neuropilin Family as Essential Pleiotropic Cell Surface Receptors

(2012) Matthew W. Parker et al.   BIOCHEMISTRY

New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2

(2012) Terry Kenakin   BRITISH JOURNAL OF PHARMACOLOGY

VEGF-Induced Vascular Permeability Is Mediated by FAK

(2012) Xiao Lei Chen et al.   DEVELOPMENTAL CELL

Targeting VEGF signalling via the neuropilin co-receptor

(2012) Snezana Djordjevic et al.   DRUG DISCOVERY TODAY

Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases

(2012) M. Shibuya   JOURNAL OF BIOCHEMISTRY

Structural Basis for Selective Vascular Endothelial Growth Factor-A (VEGF-A) Binding to Neuropilin-1

(2012) Matthew W. Parker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting Extracellular Domains D4 and D7 of Vascular Endothelial Growth Factor Receptor 2 Reveals Allosteric Receptor Regulatory Sites

(2012) C. A. C. Hyde et al.   MOLECULAR AND CELLULAR BIOLOGY

Vascular Endothelial Growth Factor A in Intraocular Vascular Disease

(2012) Joan W. Miller et al.   OPHTHALMOLOGY

Do Anti-Angiogenic VEGF (VEGFxxxb) Isoforms Exist? A Cautionary Tale

(2012) Sheila Harris et al.   PLoS One

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

(2012) Matthew W. Parker et al.   PLoS One

The role of heterodimerization between VEGFR-1 and VEGFR-2 in the regulation of endothelial cell homeostasis

(2012) Melissa J. Cudmore et al.   Nature Communications

The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling

(2011) Helen M. Jopling et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Binding affinities of vascular endothelial growth factor (VEGF) for heparin-derived oligosaccharides

(2011) Wenjing Zhao et al.   BIOSCIENCE REPORTS

Pericytes promote endothelial cell survival through induction of autocrine VEGF-A signaling and Bcl-w expression

(2011) M. Franco et al.   BLOOD

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization

(2011) M. S. Brozzo et al.   BLOOD

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

The cytoplasmic domain of neuropilin 1 is dispensable for angiogenesis, but promotes the spatial separation of retinal arteries and veins

(2011) A. Fantin et al.   DEVELOPMENT

Structural analysis of vascular endothelial growth factor receptor-2/ligand complexes by small-angle X-ray solution scattering

(2011) Kaisa Kisko et al.   FASEB JOURNAL

Tying the knot: The cystine signature and molecular-recognition processes of the vascular endothelial growth factor family of angiogenic cytokines

(2011) Shalini Iyer et al.   FEBS Journal

Neuropilin-1 expression in cancer and development

(2011) Adrian M Jubb et al.   JOURNAL OF PATHOLOGY

VEGF binding to NRP1 is essential for VEGF stimulation of endothelial cell migration, complex formation between NRP1 and VEGFR2, and signaling via FAK Tyr407 phosphorylation

(2011) Birger Herzog et al.   MOLECULAR BIOLOGY OF THE CELL

VEGF121b and VEGF165b are weakly angiogenic isoforms of VEGF-A

(2011) Raúl Catena et al.   Molecular Cancer

VEGF receptor 2/-3 heterodimers detected in situ by proximity ligation on angiogenic sprouts

(2010) Ingrid Nilsson et al.   EMBO JOURNAL

Quantification and cell-to-cell variation of vascular endothelial growth factor receptors

(2010) P.I. Imoukhuede et al.   EXPERIMENTAL CELL RESEARCH

Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability

(2010) Ding Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

HSPG-Binding Peptide Corresponding to the Exon 6a-Encoded Domain of VEGF Inhibits Tumor Growth by Blocking Angiogenesis in Murine Model

(2010) Tong-Young Lee et al.   PLoS One

Structural determinants of growth factor binding and specificity by VEGF receptor 2

(2010) V.-M. Leppanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct contacts between extracellular membrane-proximal domains are required for VEGF receptor activation and cell signaling

(2010) Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transmembrane domain-mediated orientation of receptor monomers in active VEGFR-2 dimers

(2009) Debora Dell'Era Dosch et al.   FASEB JOURNAL

Snake Venom Vascular Endothelial Growth Factors (VEGF-Fs) Exclusively Vary Their Structures and Functions among Species

(2009) Yasuo Yamazaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Diversity of VEGF-A as a Regulator of Its Biological Activity

(2009) Jeanette Woolard et al.   MICROCIRCULATION

Endosomes: A legitimate platform for the signaling train

(2009) J. E. Murphy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Positive and Negative Modulation of Angiogenesis by VEGFR1 Ligands

(2009) Y. Cao   Science Signaling

Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis

(2009) Alexander F. Bruns et al.   TRAFFIC

VEGF receptor protein–tyrosine kinases: Structure and regulation

(2008) Robert Roskoski   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

VEGF165b, an antiangiogenic VEGF-A isoform, binds and inhibits bevacizumab treatment in experimental colorectal carcinoma: balance of pro- and antiangiogenic VEGF-A isoforms has implications for therapy

(2008) A H R Varey et al.   BRITISH JOURNAL OF CANCER

The endogenous anti-angiogenic VEGF isoform, VEGF165b inhibits human tumour growth in mice

(2008) E S Rennel et al.   BRITISH JOURNAL OF CANCER

Vascular Endothelial Growth Factor (VEGF)-A165b Is a Weak In vitro Agonist for VEGF Receptor-2 Due to Lack of Coreceptor Binding and Deficient Regulation of Kinase Activity

(2008) H. Kawamura et al.   CANCER RESEARCH

Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1

(2008) Claudia Prahst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of pro- and anti-angiogenic isoforms of VEGF is differentially regulated by splicing and growth factors

(2008) D. G. Nowak et al.   JOURNAL OF CELL SCIENCE

Vascular endothelial growth factor regulates Stanniocalcin-1 expression via Neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth Factor-2

(2007) David I.R. Holmes et al.   CELLULAR SIGNALLING