Regulation of heat shock transcription factors and their roles in physiology and disease

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

(2017) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

(2017) Rocio Gomez-Pastor et al.   Nature Communications

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation

(2017) Ivo A Hendriks et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HSF1-deficiency affects gait coordination and cerebellar calbindin levels

(2016) Marc Ingenwerth et al.   BEHAVIOURAL BRAIN RESEARCH

The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

(2016) Han-Jou Chen et al.   BRAIN

Protein quantity-quality balance licenses growth

(2016) Kuo-Hui Su et al.   CELL CYCLE

The central role of heat shock factor 1 in synaptic fidelity and memory consolidation

(2016) Philip L. Hooper et al.   CELL STRESS & CHAPERONES

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

(2016) Andrea F. N. Rosenberger et al.   Journal of Neuroinflammation

Heat shock proteins as potential targets for protective strategies in neurodegeneration

(2016) Harm H Kampinga et al.   LANCET NEUROLOGY

The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model

(2016) Vaishali Kakkar et al.   MOLECULAR CELL

HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth

(2016) Kuo-Hui Su et al.   NATURE CELL BIOLOGY

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors

(2016) Alex M Jaeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

HSF1: Guardian of Proteostasis in Cancer

(2016) Chengkai Dai et al.   TRENDS IN CELL BIOLOGY

The transcriptional coactivator PGC1α protects against hyperthermic stress via cooperation with the heat shock factor HSF1

(2016) L Xu et al.   Cell Death & Disease

Structure of human heat-shock transcription factor 1 in complex with DNA

(2016) Tobias Neudegger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structures of HSF2 reveal mechanisms for differential regulation of human heat-shock factors

(2016) Alex M Jaeger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

(2016) Yoshinori Asano et al.   Scientific Reports

Molecular mechanism of thermosensory function of human heat shock transcription factor Hsf1

(2016) Nikolai Hentze et al.   eLife

MEK Guards Proteome Stability and Inhibits Tumor-Suppressive Amyloidogenesis via HSF1

(2015) Zijian Tang et al.   CELL

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

(2015) Eunhee Kim et al.   HUMAN MOLECULAR GENETICS

Lysine Deacetylases Regulate the Heat Shock Response Including the Age-Associated Impairment of HSF1

(2015) Elena Zelin et al.   JOURNAL OF MOLECULAR BIOLOGY

Uncoupling Stress-Inducible Phosphorylation of Heat Shock Factor 1 from Its Activation

(2015) Marek A. Budzyński et al.   MOLECULAR AND CELLULAR BIOLOGY

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

(2015) Nikos Kourtis et al.   NATURE CELL BIOLOGY

Heat-shock factor 2 is a suppressor of prostate cancer invasion

(2015) J K Björk et al.   ONCOGENE

Direct link between metabolic regulation and the heat-shock response through the transcriptional regulator PGC-1α

(2015) Neri Minsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity

(2015) Ke Tan et al.   Nature Communications

The Reprogramming of Tumor Stroma by HSF1 Is a Potent Enabler of Malignancy

(2014) Ruth Scherz-Shouval et al.   CELL

Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1

(2014) Swasti Raychaudhuri et al.   CELL

Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK

(2014) S. Dai et al.   EMBO JOURNAL

Heat shock factor 2 is a stress-responsive mediator of neuronal migration defects in models of fetal alcohol syndrome

(2014) R. El Fatimy et al.   EMBO Molecular Medicine

Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease

(2014) M. Maheshwari et al.   HUMAN MOLECULAR GENETICS

Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders

(2014) Alisia Carnemolla et al.   HUMAN MOLECULAR GENETICS

Expression of HSF2 decreases in mitosis to enable stress-inducible transcription and cell survival

(2014) Alexandra N. Elsing et al.   JOURNAL OF CELL BIOLOGY

SIRT1 Knockdown Promotes Neural Differentiation and Attenuates the Heat Shock Response

(2014) Diana J. Liu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment

(2014) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

HDAC6–ubiquitin interaction controls the duration of HSF1 activation after heat shock

(2014) Lydia Pernet et al.   MOLECULAR BIOLOGY OF THE CELL

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

HSF1 regulation of β-catenin in mammary cancer cells through control of HuR/elavL1 expression

(2014) S-D Chou et al.   ONCOGENE

Casein Kinase II Induced Polymerization of Soluble TDP-43 into Filaments Is Inhibited by Heat Shock Proteins

(2014) Yari Carlomagno et al.   PLoS One

A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1

(2014) Daniel W. Neef et al.   Cell Reports

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

(2014) Seiji Watanabe et al.   Molecular Brain

Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis

(2014) Nicolas Dzamko et al.   Frontiers in Molecular Neuroscience

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

(2013) Yu-Qing Jiang et al.   BRAIN RESEARCH

Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality

(2013) Carole Sourbier et al.   CANCER CELL

Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis

(2013) Pei-Yi Lin et al.   Molecular Neurodegeneration

Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue

(2013) Zhongxiao Wan et al.   Obesity

Transcriptional response to stress in the dynamic chromatin environment of cycling and mitotic cells

(2013) Anniina Vihervaara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tight Coordination of Protein Translation and HSF1 Activation Supports the Anabolic Malignant State

(2013) S. Santagata et al.   SCIENCE

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration

(2013) Naohide Kondo et al.   Nature Communications

Genetic Selection for Constitutively Trimerized Human HSF1 Mutants Identifies a Role for Coiled-Coil Motifs in DNA Binding

(2013) Daniel W. Neef et al.   G3-Genes Genomes Genetics

Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

(2012) Daniel R. Ciocca et al.   ARCHIVES OF TOXICOLOGY

Suppression of protein aggregation by chaperone modification of high molecular weight complexes

(2012) John Labbadia et al.   BRAIN

HSF1 Drives a Transcriptional Program Distinct from Heat Shock to Support Highly Malignant Human Cancers

(2012) Marc L. Mendillo et al.   CELL

Heat Shock Factor Hsf1 Cooperates with ErbB2 (Her2/Neu) Protein to Promote Mammary Tumorigenesis and Metastasis

(2012) Caixia Xi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

(2012) Chengkai Dai et al.   JOURNAL OF CLINICAL INVESTIGATION

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Post-Translational Modification of Human Heat Shock Factors and Their Functions: A Recent Update by Proteomic Approach

(2012) Yan-Ming Xu et al.   JOURNAL OF PROTEOME RESEARCH

Heat Shock Transcription Factor Hsf1 Is Involved in Tumor Progression via Regulation of Hypoxia-Inducible Factor 1 and RNA-Binding Protein HuR

(2012) V. L. Gabai et al.   MOLECULAR AND CELLULAR BIOLOGY

The p23 Molecular Chaperone and GCN5 Acetylase Jointly Modulate Protein-DNA Dynamics and Open Chromatin Status

(2012) Elena Zelin et al.   MOLECULAR CELL

RPA Assists HSF1 Access to Nucleosomal DNA by Recruiting Histone Chaperone FACT

(2012) Mitsuaki Fujimoto et al.   MOLECULAR CELL

Expression of Taurine Transporter (TauT) is Modulated by Heat Shock Factor 1 (HSF1) in Motor Neurons of ALS

(2012) Min-Kyung Jung et al.   MOLECULAR NEUROBIOLOGY

mTOR Is Essential for the Proteotoxic Stress Response, HSF1 Activation and Heat Shock Protein Synthesis

(2012) Shiuh-Dih Chou et al.   PLoS One

Impaired Heat Shock Response in Cells Expressing Full-Length Polyglutamine-Expanded Huntingtin

(2012) Sidhartha M. Chafekar et al.   PLoS One

PGC-1  Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function

(2012) T. Tsunemi et al.   Science Translational Medicine

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

(2011) D. Grahame Hardie   BIOCHEMICAL SOCIETY TRANSACTIONS

β-Amyloid triggers ALS-associated TDP-43 pathology in AD models

(2011) Alexander M. Herman et al.   BRAIN RESEARCH

Heat Shock Transcription Factor 1 Is a Key Determinant of HCC Development by Regulating Hepatic Steatosis and Metabolic Syndrome

(2011) Xiongjie Jin et al.   Cell Metabolism

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation

(2011) Toyohide Shinkawa et al.   MOLECULAR BIOLOGY OF THE CELL

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

(2011) Daniel W. Neef et al.   NATURE REVIEWS DRUG DISCOVERY

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

(2011) Liliana Batista-Nascimento et al.   PLoS One

Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1

(2011) S. Uchida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphological Changes of the Human Purkinje Cells and Deposition of Neuritic Plaques and Neurofibrillary Tangles on the Cerebellar Cortex of Alzheimer’s Disease

(2010) Ioannis A. Mavroudis et al.   American Journal of Alzheimers Disease and Other Dementias

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

(2010) Naoki Hayashida et al.   EMBO JOURNAL

The heat shock factor family and adaptation to proteotoxic stress

(2010) Mitsuaki Fujimoto et al.   FEBS Journal

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Heat-shock transcription factor HSF1 has a critical role in human epidermal growth factor receptor-2-induced cellular transformation and tumorigenesis

(2010) L Meng et al.   ONCOGENE

Protein Kinase A Binds and Activates Heat Shock Factor 1

(2010) Ayesha Murshid et al.   PLoS One

Transcriptional coactivator PGC-1  promotes peroxisomal remodeling and biogenesis

(2010) A. Bagattin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6

(2009) Li Li et al.   GENES TO CELLS

Heterotrimerization of Heat-Shock Factors 1 and 2 Provides a Transcriptional Switch in Response to Distinct Stimuli

(2009) Anton Sandqvist et al.   MOLECULAR BIOLOGY OF THE CELL

A Novel Mouse HSF3 Has the Potential to Activate Nonclassical Heat-Shock Genes during Heat Shock

(2009) Mitsuaki Fujimoto et al.   MOLECULAR BIOLOGY OF THE CELL

Dominant-positive HSF1 decreases alpha-synuclein level and alpha-synuclein-induced toxicity

(2009) Xu Liangliang et al.   MOLECULAR BIOLOGY REPORTS

Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth

(2009) Y H Zhao et al.   ONCOGENE

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Nuclear accumulation of polyglutamine disease proteins and neuropathology

(2009) Lauren S Havel et al.   Molecular Brain

Neural differentiation and the attenuated heat shock response

(2008) Jingxian Yang et al.   BRAIN RESEARCH

HSF1 as a Mitotic Regulator: Phosphorylation of HSF1 by Plk1 Is Essential for Mitotic Progression

(2008) Y.-J. Lee et al.   CANCER RESEARCH

Analysis of HSF4 Binding Regions Reveals Its Necessity for Gene Regulation during Development and Heat Shock Response in Mouse Lenses

(2008) Mitsuaki Fujimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of Gene Expression in Primary Neuron Models of Huntington's Disease Shows That Polyglutamine-Related Effects on the Striatal Transcriptome May Not Be Dependent on Brain Circuitry

(2008) H. Runne et al.   JOURNAL OF NEUROSCIENCE