Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis

Cytosolic proteins lose solubility as amyloid deposits in a transgenic mouse model of Alzheimer-type amyloidosis

(2013) Guilian Xu et al.   HUMAN MOLECULAR GENETICS

Pseudophosphorylated αB-Crystallin Is a Nuclear Chaperone Imported into the Nucleus with Help of the SMN Complex

(2013) John den Engelsman et al.   PLoS One

Glutamine-mediated Dual Regulation of Heat Shock Transcription Factor-1 Activation and Expression

(2012) Hongyu Xue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Over-expression of heat shock factor 1 phenocopies the effect of chronic inhibition of TOR by rapamycin and is sufficient to ameliorate Alzheimer's-like deficits in mice modeling the disease

(2012) Anson Pierce et al.   JOURNAL OF NEUROCHEMISTRY

Chaperones in autophagy

(2012) Susmita Kaushik et al.   PHARMACOLOGICAL RESEARCH

The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila

(2012) Jenna M. Gregory et al.   PLoS One

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

(2012) Edward Pokrishevsky et al.   PLoS One

Human Neural Stem Cell Replacement Therapy for Amyotrophic Lateral Sclerosis by Spinal Transplantation

(2012) Michael P. Hefferan et al.   PLoS One

Proteins with neomorphic moonlighting functions in disease

(2011) Constance J. Jeffery   IUBMB LIFE

Proteins That Bind to Misfolded Mutant Superoxide Dismutase-1 in Spinal Cords from Transgenic Amyotrophic Lateral Sclerosis (ALS) Model Mice

(2011) Per Zetterström et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Peptide Substrate Binding Properties of 110-kDa Heat-shock Protein (Hsp110) Determine Its Distinct Chaperone Activity

(2011) Xinping Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clinical aspects and pathology of Alexander disease, and morphological and functional alteration of astrocytes induced by GFAP mutation

(2011) Tomokatsu Yoshida et al.   NEUROPATHOLOGY

14-3-3 proteins in neurodegeneration

(2011) Petra Steinacker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

ANS Binding Reveals Common Features of Cytotoxic Amyloid Species

(2010) Benedetta Bolognesi et al.   ACS Chemical Biology

Amyotrophic lateral sclerosis is a non-amyloid disease in which extensive misfolding of SOD1 is unique to the familial form

(2010) Aaron Kerman et al.   ACTA NEUROPATHOLOGICA

Impaired glucose tolerance in patients with amyotrophic lateral sclerosis

(2010) Pierre-Francois Pradat et al.   Amyotrophic Lateral Sclerosis

A Novel mouse model of enhanced proteostasis: Full-length human heat shock factor 1 transgenic mice

(2010) Anson Pierce et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bioinformatic and experimental survey of 14-3-3-binding sites

(2010) Catherine Johnson et al.   BIOCHEMICAL JOURNAL

Neuroprotective Drug Riluzole Amplifies the Heat Shock Factor 1 (HSF1)- and Glutamate Transporter 1 (GLT1)-dependent Cytoprotective Mechanisms for Neuronal Survival

(2010) Alice Y. C. Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper and Zinc Metallation Status of Copper-Zinc Superoxide Dismutase from Amyotrophic Lateral Sclerosis Transgenic Mice

(2010) Herman L. Lelie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exposure of Hydrophobic Surfaces Initiates Aggregation of Diverse ALS-Causing Superoxide Dismutase-1 Mutants

(2010) Christian Münch et al.   JOURNAL OF MOLECULAR BIOLOGY

Identification of Novel 14-3-3ζ Interacting Proteins by Quantitative Immunoprecipitation Combined with Knockdown (QUICK)

(2010) Feng Ge et al.   JOURNAL OF PROTEOME RESEARCH

Chaperone networks: Tipping the balance in protein folding diseases

(2010) Cindy Voisine et al.   NEUROBIOLOGY OF DISEASE

Structural and Biophysical Properties of the Pathogenic SOD1 Variant H46R/H48Q†

(2009) Duane D. Winkler et al.   BIOCHEMISTRY

Metal Deficiency Increases Aberrant Hydrophobicity of Mutant Superoxide Dismutases That Cause Amyotrophic Lateral Sclerosis

(2009) Ashutosh Tiwari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyotrophic Lateral Sclerosis-linked Mutant SOD1 Sequesters Hu Antigen R (HuR) and TIA-1-related Protein (TIAR)

(2009) Liang Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond

(2009) Hristelina Ilieva et al.   JOURNAL OF CELL BIOLOGY

Serine 58 of 14-3-3  Is a Molecular Switch Regulating ASK1 and Oxidant Stress-Induced Cell Death

(2009) J. Zhou et al.   MOLECULAR AND CELLULAR BIOLOGY

New vaccine development for chronic brain disease

(2009) Alan DT Barrett et al.   NEUROPSYCHOPHARMACOLOGY

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

(2009) Manuela Basso et al.   PLoS One

UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein

(2009) Ian N.M. Day et al.   PROGRESS IN NEUROBIOLOGY

Effect of mutations mimicking phosphorylation on the structure and properties of human 14-3-3ζ

(2008) Nikolai N. Sluchanko et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

GAPDH Is Conformationally and Functionally Altered in Association with Oxidative Stress in Mouse Models of Amyotrophic Lateral Sclerosis

(2008) Anson Pierce et al.   JOURNAL OF MOLECULAR BIOLOGY

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Riluzole Increases the Amount of Latent HSF1 for an Amplified Heat Shock Response and Cytoprotection

(2008) Jingxian Yang et al.   PLoS One

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

(2008) A. D. Steele et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice

(2008) K. Yamanaka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY