Contesting the dogma of an age-related heat shock response impairment: implications for cardiac-specific age-related disorders

Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes

(2013) Mohammed Mahidur Rahman et al.   AGING CELL

XBP-1 Is a Cell-Nonautonomous Regulator of Stress Resistance and Longevity

(2013) Rebecca C. Taylor et al.   CELL

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Oxidative stress response elicited by mitochondrial dysfunction: Implication in the pathophysiology of aging

(2013) Chih-Hao Wang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Proteotoxicity and Cardiac Dysfunction — Alzheimer's Disease of the Heart?

(2013) Monte S. Willis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteomic profiling of cardiomyopathic tissue from the agedmdxmodel of Duchenne muscular dystrophy reveals a drastic decrease in laminin, nidogen and annexin

(2013) Ashling Holland et al.   PROTEOMICS

Proteotoxic stress and circulating cell stress proteins in the cardiovascular diseases

(2012) Brian Henderson et al.   CELL STRESS & CHAPERONES

Growth Factors, Nutrient Signaling, and Cardiovascular Aging

(2012) Luigi Fontana et al.   CIRCULATION RESEARCH

Cardiac transthyretin amyloidosis

(2012) Jason N Dungu et al.   HEART

The Novel Oral Hsp90 Inhibitor NVP-HSP990 Exhibits Potent and Broad-spectrum Antitumor Activities In Vitro and In Vivo

(2012) D. L. Menezes et al.   MOLECULAR CANCER THERAPEUTICS

From Pluripotency to Distinct Cardiomyocyte Subtypes

(2012) Robert David et al.   PHYSIOLOGY

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting HSP 90 Induces Apoptosis and Inhibits Critical Survival and Proliferation Pathways in Multiple Myeloma

(2011) T. Khong et al.   MOLECULAR CANCER THERAPEUTICS

Aging and disease: connections to sirtuins

(2010) Gizem Donmez et al.   AGING CELL

Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease

(2010) Christian Landles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitochondrial UPR - protecting organelle protein homeostasis

(2010) C. M. Haynes et al.   JOURNAL OF CELL SCIENCE

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging

(2009) A. Ben-Zvi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stress-Inducible Regulation of Heat Shock Factor 1 by the Deacetylase SIRT1

(2009) S. D. Westerheide et al.   SCIENCE

Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation inalpha2‐macroglobulinandtau: A population‐based autopsy study

(2008) Maarit Tanskanen et al.   ANNALS OF MEDICINE

Genetic Evidence Linking Age-Dependent Attenuation of the 26S Proteasome with the Aging Process

(2008) A. Tonoki et al.   MOLECULAR AND CELLULAR BIOLOGY

Optimisation of region-specific reference gene selection and relative gene expression analysis methods for pre-clinical trials of Huntington's disease

(2008) Caroline L Benn et al.   Molecular Neurodegeneration

Enhanced Recovery from Contraction-Induced Damage in Skeletal Muscles of Old Mice Following Treatment with the Heat Shock Protein Inducer 17-(Allylamino)-17-Demethoxygeldanamycin

(2008) Anna C. Kayani et al.   REJUVENATION RESEARCH

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE