Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington’s disease

Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology

(2016) Andrea F. N. Rosenberger et al.   Journal of Neuroinflammation

The Biology of Huntingtin

(2016) Frédéric Saudou et al.   NEURON

Celastrol Protects against Obesity and Metabolic Dysfunction through Activation of a HSF1-PGC1α Transcriptional Axis

(2015) Xinran Ma et al.   Cell Metabolism

NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

(2015) Eunhee Kim et al.   HUMAN MOLECULAR GENETICS

Altered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease

(2015) Tim Indersmitten et al.   JOURNAL OF NEUROPHYSIOLOGY

FBXW7 modulates cellular stress response and metastatic potential through HSF1 post-translational modification

(2015) Nikos Kourtis et al.   NATURE CELL BIOLOGY

PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically

(2015) Audrey S Dickey et al.   NATURE MEDICINE

Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1

(2014) Swasti Raychaudhuri et al.   CELL

Dexamethasone induces heat shock response and slows down disease progression in mouse and fly models of Huntington's disease

(2014) M. Maheshwari et al.   HUMAN MOLECULAR GENETICS

HSF1 at a glance

(2014) A. Vihervaara et al.   JOURNAL OF CELL SCIENCE

Hsp90 Chaperone Inhibitor 17-AAG Attenuates A -Induced Synaptic Toxicity and Memory Impairment

(2014) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

Huntingtin Is Required for Normal Excitatory Synapse Development in Cortical and Striatal Circuits

(2014) S. U. McKinstry et al.   JOURNAL OF NEUROSCIENCE

Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines

(2014) W. Christopher Risher et al.   PLoS One

A Direct Regulatory Interaction between Chaperonin TRiC and Stress-Responsive Transcription Factor HSF1

(2014) Daniel W. Neef et al.   Cell Reports

Skeletal muscle pathology in Huntington's disease

(2014) Daniel Zielonka et al.   Frontiers in Physiology

Increased heat shock transcription factor 1 in the cerebellum reverses the deficiency of Purkinje cells in Alzheimer's disease

(2013) Yu-Qing Jiang et al.   BRAIN RESEARCH

Loss of corticostriatal and thalamostriatal synaptic terminals precedes striatal projection neuron pathology in heterozygous Q140 Huntington's disease mice

(2013) Y.P. Deng et al.   NEUROBIOLOGY OF DISEASE

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration

(2013) Naohide Kondo et al.   Nature Communications

Impaired Heat Shock Response in Cells Expressing Full-Length Polyglutamine-Expanded Huntingtin

(2012) Sidhartha M. Chafekar et al.   PLoS One

Comprehensive Behavioral and Molecular Characterization of a New Knock-In Mouse Model of Huntington’s Disease: zQ175

(2012) Liliana B. Menalled et al.   PLoS One

Regulation of HSF1 Function in the Heat Stress Response: Implications in Aging and Disease

(2011) Julius Anckar et al.   Annual Review of Biochemistry

Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease

(2011) John Labbadia et al.   JOURNAL OF CLINICAL INVESTIGATION

Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity

(2011) Vittorio Calabrese et al.   MOLECULAR ASPECTS OF MEDICINE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

Kinase inhibitors modulate huntingtin cell localization and toxicity

(2011) Randy Singh Atwal et al.   Nature Chemical Biology

Heat shock transcription factor 1 as a therapeutic target in neurodegenerative diseases

(2011) Daniel W. Neef et al.   NATURE REVIEWS DRUG DISCOVERY

Deciphering Human Heat Shock Transcription Factor 1 Regulation via Post-Translational Modification in Yeast

(2011) Liliana Batista-Nascimento et al.   PLoS One

Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT

(2010) Naoki Hayashida et al.   EMBO JOURNAL

Heat shock factors: integrators of cell stress, development and lifespan

(2010) Malin Åkerfelt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

17-AAG increases autophagic removal of mutant androgen receptor in spinal and bulbar muscular atrophy

(2010) Paola Rusmini et al.   NEUROBIOLOGY OF DISEASE

Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

(2010) Daniel W. Neef et al.   PLOS BIOLOGY

Huntington's disease: The current state of research with peripheral tissues

(2009) Jenny Sassone et al.   EXPERIMENTAL NEUROLOGY

Mutant Huntingtin reduces HSP70 expression through the sequestration of NF-Y transcription factor

(2008) Tomoyuki Yamanaka et al.   EMBO JOURNAL

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ctip2 Controls the Differentiation of Medium Spiny Neurons and the Establishment of the Cellular Architecture of the Striatum

(2008) P. Arlotta et al.   JOURNAL OF NEUROSCIENCE

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE