Talin – the master of integrin adhesions

AMPK negatively regulates tensin-dependent integrin activity

(2017) Maria Georgiadou et al.   JOURNAL OF CELL BIOLOGY

SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

(2017) Johanna Lilja et al.   NATURE CELL BIOLOGY

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

(2016) Katarzyna Plak et al.   BMC CELL BIOLOGY

Mechanosensing in cell–matrix adhesions – Converting tension into chemical signals

(2016) Vesa P. Hytönen et al.   EXPERIMENTAL CELL RESEARCH

Gα13Switch Region 2 Relieves Talin Autoinhibition to Activate αIIbβ3 Integrin

(2016) James Schiemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

(2016) Abhishek Kumar et al.   JOURNAL OF CELL BIOLOGY

The kindlin family: functions, signaling properties and implications for human disease

(2016) Emanuel Rognoni et al.   JOURNAL OF CELL SCIENCE

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Kank2 activates talin, reduces force transduction across integrins and induces central adhesion formation

(2016) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

(2016) Alberto Elosegui-Artola et al.   NATURE CELL BIOLOGY

Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration

(2016) Hao Zhang et al.   STRUCTURE

LD Motif Recognition by Talin: Structure of the Talin-DLC1 Complex

(2016) Thomas Zacharchenko et al.   STRUCTURE

The mechanical response of talin

(2016) Mingxi Yao et al.   Nature Communications

Coordinated integrin activation by actin-dependent force during T-cell migration

(2016) Pontus Nordenfelt et al.   Nature Communications

Talin-KANK1 interaction controls the recruitment of cortical microtubule stabilizing complexes to focal adhesions

(2016) Benjamin P Bouchet et al.   eLife

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Loss of the Rap1 effector RIAM results in leukocyte adhesion deficiency due to impaired  2 integrin function in mice

(2015) S. Klapproth et al.   BLOOD

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation

(2015) Rishita Changede et al.   DEVELOPMENTAL CELL

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

(2015) William A. Comrie et al.   JOURNAL OF CELL BIOLOGY

Blocking neutrophil integrin activation prevents ischemia–reperfusion injury

(2015) Tadayuki Yago et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo quantitative analysis of Talin turnover in response to force

(2015) Guðlaug Katrín Hákonardóttir et al.   MOLECULAR BIOLOGY OF THE CELL

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

(2015) Philip Vitorino et al.   NATURE

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Talin determines the nanoscale architecture of focal adhesions

(2015) Jaron Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

(2015) Frederic Lagarrigue et al.   Nature Communications

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice

(2014) S. Stritt et al.   BLOOD

A talin mutant that impairs talin-integrin binding in platelets decelerates  IIb 3 activation without pathological bleeding

(2014) L. Stefanini et al.   BLOOD

Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions

(2014) Alexia I. Bachir et al.   CURRENT BIOLOGY

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural and Mechanistic Insights into the Recruitment of Talin by RIAM in Integrin Signaling

(2014) Yu-Chung Chang et al.   STRUCTURE

Conformational activation of talin by RIAM triggers integrin-mediated cell adhesion

(2014) Jun Yang et al.   Nature Communications

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering

(2014) Stephanie J. Ellis et al.   PLoS Genetics

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

Talin Autoinhibition Is Required for Morphogenesis

(2013) Stephanie J. Ellis et al.   CURRENT BIOLOGY

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

Two modes of integrin activation form a binary molecular switch in adhesion maturation

(2013) Ho-Sup Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Cell adhesion in Drosophila: versatility of cadherin and integrin complexes during development

(2012) Natalia A Bulgakova et al.   CURRENT OPINION IN CELL BIOLOGY

Subcellular Localization of Talin Is Regulated by Inter-domain Interactions

(2012) Asoka Banno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

Zasp regulates integrin activation

(2012) M. Bouaouina et al.   JOURNAL OF CELL SCIENCE

Mechanical force regulates integrin turnover in Drosophila in vivo

(2012) Mary Pines et al.   NATURE CELL BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Scanning angle interference microscopy reveals cell dynamics at the nanoscale

(2012) Matthew J Paszek et al.   NATURE METHODS

Talin couples the actomyosin cortex to the plasma membrane during rear retraction and cytokinesis

(2012) M. Tsujioka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

The C terminus of talin links integrins to cell cycle progression

(2011) Pengbo Wang et al.   JOURNAL OF CELL BIOLOGY

A central multifunctional role of integrin-linked kinase at muscle attachment sites

(2011) C. G. Zervas et al.   JOURNAL OF CELL SCIENCE

In vivo functional analysis reveals specific roles for the integrin-binding sites of talin

(2011) S. J. Ellis et al.   JOURNAL OF CELL SCIENCE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?

(2010) Irit Gottfried et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Distinct developmental roles for direct and indirect talin-mediated linkage to actin

(2010) Ari Franco-Cea et al.   DEVELOPMENTAL BIOLOGY

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

(2010) Petra M. Kopp et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

(2010) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ancient origin of the integrin-mediated adhesion and signaling machinery

(2010) A. Sebe-Pedros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

FERM proteins in animal morphogenesis

(2009) Ulrich Tepass   CURRENT OPINION IN GENETICS & DEVELOPMENT

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

(2009) F. J. Conti et al.   DEVELOPMENT

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

Structural Determinants of Integrin Binding to the Talin Rod

(2009) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of High Affinity Interactions in the Talin C Terminus

(2009) Mirko Himmel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Integrin signalling at a glance

(2009) D. S. Harburger et al.   JOURNAL OF CELL SCIENCE

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Overlapping Functions of the Two Talin Homologues inDictyostelium

(2008) Masatsune Tsujioka et al.   EUKARYOTIC CELL

Identification of a repeated domain within mammalian α-synemin that interacts directly with talin

(2008) Ning Sun et al.   EXPERIMENTAL CELL RESEARCH

The Talin Rod IBS2 α-Helix Interacts with the β3 Integrin Cytoplasmic Tail Membrane-proximal Helix by Establishing Charge Complementary Salt Bridges

(2008) Sophie Rodius et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantification of integrin receptor agonism by fluorescence lifetime imaging

(2008) M. Parsons et al.   JOURNAL OF CELL SCIENCE

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter