The integrin adhesome network at a glance

Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

(2016) Adam Byron et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome

(2016) Edward R. Horton et al.   EXPERIMENTAL CELL RESEARCH

Tumor promoter PMA enhances kindlin-2 and decreases vimentin recruitment into cell adhesion sites

(2016) Maria Salmela et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Kindlin-2 directly binds actin and regulates integrin outside-in signaling

(2016) Kamila Bledzka et al.   JOURNAL OF CELL BIOLOGY

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition

(2016) Edward R. Horton et al.   JOURNAL OF CELL BIOLOGY

LAR protein tyrosine phosphatase regulates focal adhesions through CDK1

(2016) Adil R. Sarhan et al.   JOURNAL OF CELL SCIENCE

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Cole-Carpenter Syndrome Is Caused by a Heterozygous Missense Mutation in P4HB

(2015) Frank Rauch et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of integrin-mediated adhesions

(2015) Daniel V Iwamoto et al.   CURRENT OPINION IN CELL BIOLOGY

Protein Neighbors and Proximity Proteomics

(2015) Johanna S. Rees et al.   MOLECULAR & CELLULAR PROTEOMICS

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells

(2015) Jila N. Ajeian et al.   Proteomics Clinical Applications

Emerging properties of adhesion complexes: what are they and what do they do?

(2015) Jonathan D. Humphries et al.   TRENDS IN CELL BIOLOGY

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

(2015) Joseph Robertson et al.   Nature Communications

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

(2015) Adam Byron et al.   Nature Communications

Integrin Cytoplasmic Tail Interactions

(2014) Elizabeth M. Morse et al.   BIOCHEMISTRY

A Proteome-Scale Map of the Human Interactome Network

(2014) Thomas Rolland et al.   CELL

Microtubules Regulate Focal Adhesion Dynamics through MAP4K4

(2014) Jiping Yue et al.   DEVELOPMENTAL CELL

GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment

(2014) I.-H. Huang et al.   JOURNAL OF CELL SCIENCE

The integrin adhesome: from genes and proteins to human disease

(2014) Sabina E. Winograd-Katz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Microtubule-Dependent Modulation of Adhesion Complex Composition

(2014) Daniel H. J. Ng et al.   PLoS One

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

(2014) Z. Guo et al.   Science Signaling

Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol

(2014) Jan-Erik Hoffmann et al.   eLife

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

Dynamic Regulation of the Structure and Functions of Integrin Adhesions

(2013) Haguy Wolfenson et al.   DEVELOPMENTAL CELL

Mechanosensitivity and compositional dynamics of cell–matrix adhesions

(2013) Herbert B Schiller et al.   EMBO REPORTS

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Effect of Actomyosin Relaxation on the Dynamic Properties of Focal Adhesion Proteins

(2013) Irena Lavelin et al.   PLoS One

Opening the floodgates: proteomics and the integrin adhesome

(2012) Tamar Geiger et al.   CURRENT OPINION IN CELL BIOLOGY

Efficiently mining protein interaction dependencies from large text corpora

(2012) Johannes Köster et al.   Integrative Biology

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

(2012) Adam Byron et al.   PROTEOMICS

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

MatrixDB, a database focused on extracellular protein–protein and protein–carbohydrate interactions

(2009) Emilie Chautard et al.   BIOINFORMATICS

Interferometric fluorescent super-resolution microscopy resolves 3D cellular ultrastructure

(2009) G. Shtengel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

Investigating complexity of protein–protein interactions in focal adhesions

(2008) Tanmay P. Lele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Integrated network analysis platform for protein-protein interactions

(2008) Jianmin Wu et al.   NATURE METHODS