Integrin inactivators: balancing cellular functions in vitro and in vivo

A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells

(2013) Jianchao Gao et al.   FEBS LETTERS

Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation

(2013) Weizhi Liu et al.   MOLECULAR CELL

Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation

(2012) C. T. Lefort et al.   BLOOD

Distinct Roles of Talin and Kindlin in Regulating Integrin α5β1 Function and Trafficking

(2012) Coert Margadant et al.   CURRENT BIOLOGY

Mechanical control of integrin-mediated adhesion and signaling

(2012) David Boettiger   CURRENT OPINION IN CELL BIOLOGY

Assembly and disassembly of cell matrix adhesions

(2012) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

Integrin αIIbβ3Inside-out Activation

(2012) Lisa Kurtz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RSK2 Protein Suppresses Integrin Activation and Fibronectin Matrix Assembly and Promotes Cell Migration

(2012) Joanna E. Gawecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis of the junctional anchorage of the cerebral cavernous malformations complex

(2012) Alexandre R. Gingras et al.   JOURNAL OF CELL BIOLOGY

Talin activates integrins by altering the topology of the β transmembrane domain

(2012) Chungho Kim et al.   JOURNAL OF CELL BIOLOGY

Targeting and transport: How microtubules control focal adhesion dynamics

(2012) Samantha Stehbens et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

(2012) Masamichi Nagae et al.   JOURNAL OF CELL BIOLOGY

FAK promotes recruitment of talin to nascent adhesions to control cell motility

(2012) Christine Lawson et al.   JOURNAL OF CELL BIOLOGY

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

(2012) Florian Steinberg et al.   JOURNAL OF CELL BIOLOGY

Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells

(2012) M. Baldassarre et al.   JOURNAL OF CELL SCIENCE

A functional genetic screen reveals new regulators of  1-integrin activity

(2012) T. Pellinen et al.   JOURNAL OF CELL SCIENCE

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

United we stand – integrating the actin cytoskeleton and cell–matrix adhesions in cellular mechanotransduction

(2012) Ulrich S. Schwarz et al.   JOURNAL OF CELL SCIENCE

SHARPIN is a key regulator of immune and inflammatory responses

(2012) Zhe Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer

(2012) Reetta Virtakoivu et al.   MOLECULAR BIOLOGY OF THE CELL

Targeting filamin A reduces K-RAS–induced lung adenocarcinomas and endothelial response to tumor growth in mice

(2012) Rajesh K Nallapalli et al.   Molecular Cancer

Integrins β1 and β3 exhibit distinct dynamic nanoscale organizations inside focal adhesions

(2012) Olivier Rossier et al.   NATURE CELL BIOLOGY

Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail

(2012) Ralph Thomas Böttcher et al.   NATURE CELL BIOLOGY

The Primacy of β1 Integrin Activation in the Metastatic Cascade

(2012) Hisashi Kato et al.   PLoS One

Distinct Recycling of Active and Inactive β1 Integrins

(2012) Antti Arjonen et al.   TRAFFIC

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the  IIb 3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

(2011) S. Kunishima et al.   BLOOD

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Rab25 and CLIC3 Collaborate to Promote Integrin Recycling from Late Endosomes/Lysosomes and Drive Cancer Progression

(2011) Marta A. Dozynkiewicz et al.   DEVELOPMENTAL CELL

Identification of Integrin β Subunit Mutations That Alter Affinity for Extracellular Matrix Ligand

(2011) Timmy Kendall et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Osteoblast mineralization requires β1 integrin/ICAP-1–dependent fibronectin deposition

(2011) Molly Brunner et al.   JOURNAL OF CELL BIOLOGY

Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking

(2011) S. Tiwari et al.   JOURNAL OF CELL SCIENCE

Filamin depletion blocks endoplasmic spreading and destabilizes force-bearing adhesions

(2011) Christopher D. Lynch et al.   MOLECULAR BIOLOGY OF THE CELL

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A

(2011) A. J. Ehrlicher et al.   NATURE

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Migfilin and Filamin as Regulators of Integrin Activation in Endothelial Cells and Neutrophils

(2011) Mitali Das et al.   PLoS One

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Ubiquitination of α5β1 Integrin Controls Fibroblast Migration through Lysosomal Degradation of Fibronectin-Integrin Complexes

(2010) Viola Hélène Lobert et al.   DEVELOPMENTAL CELL

Unique and redundant functions of integrins in the epidermis

(2010) Coert Margadant et al.   FASEB JOURNAL

Tyrosine Phosphorylation of Integrin β3Regulates Kindlin-2 Binding and Integrin Activation

(2010) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NPIY motif in the integrin  1 tail dictates the requirement for talin-1 in outside-in signaling

(2010) B. Nieves et al.   JOURNAL OF CELL SCIENCE

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

(2010) Yingjie Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Newly identified tumor-associated role of human Sharpin

(2010) Jinyoung Jung et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Integrin expression profiling identifies integrin alpha5 and beta1 as prognostic factors in early stage non-small cell lung cancer

(2010) Anne-Marie C Dingemans et al.   Molecular Cancer

The final steps of integrin activation: the end game

(2010) Sanford J. Shattil et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion

(2010) J Nevo et al.   ONCOGENE

Filamins in cell signaling, transcription and organ development

(2010) Alex-Xianghua Zhou et al.   TRENDS IN CELL BIOLOGY

Integrins and Extracellular Matrix in Mechanotransduction

(2010) M. A. Schwartz   Cold Spring Harbor Perspectives in Biology

Regulation of integrin activity and signalling

(2009) Carl G. Gahmberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

An Activating β1 Integrin Mutation Increases the Conversion of Benign to Malignant Skin Tumors

(2009) Manuela Ferreira et al.   CANCER RESEARCH

Interplay between cell adhesion and growth factor receptors: from the plasma membrane to the endosomes

(2009) Johanna Ivaska et al.   CELL AND TISSUE RESEARCH

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

(2009) F. J. Conti et al.   DEVELOPMENT

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin

(2009) Ulla Pentikäinen et al.   JOURNAL OF MOLECULAR BIOLOGY

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

Filamins Regulate Cell Spreading and Initiation of Cell Migration

(2009) Massimiliano Baldassarre et al.   PLoS One

Structure of an integrin  IIb 3 transmembrane-cytoplasmic heterocomplex provides insight into integrin activation

(2009) J. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Mechanically Activated Integrin Switch Controls  5 1 Function

(2009) J. C. Friedland et al.   SCIENCE

Genetic perturbation of the putative cytoplasmic membrane-proximal salt bridge aberrantly activates  4 integrins

(2008) Y. Imai et al.   BLOOD

 2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding

(2008) H. Takala et al.   BLOOD

Kindlin-2 controls bidirectional signaling of integrins

(2008) E. Montanez et al.   GENES & DEVELOPMENT

Cell adaptive response to extracellular matrix density is controlled by ICAP-1–dependent β1-integrin affinity

(2008) Angélique Millon-Frémillon et al.   JOURNAL OF CELL BIOLOGY

Integrin αIIbβ3 in a Membrane Environment Remains the Same Height after Mn2+ Activation when Observed by Cryoelectron Tomography

(2008) Feng Ye et al.   JOURNAL OF MOLECULAR BIOLOGY

Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

(2008) Colin K. Choi et al.   NATURE CELL BIOLOGY

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

(2008) Kaylene J. Simpson et al.   NATURE CELL BIOLOGY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction

(2008) Siegfried Ussar et al.   PLoS Genetics