Extracellular rigidity sensing by talin isoform-specific mechanical linkages

Mechanics regulates ATP-stimulated collective calcium response in fibroblast cells

(2015) Josephine Lembong et al.   Journal of the Royal Society Interface

Talin determines the nanoscale architecture of focal adhesions

(2015) Jaron Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanical Feedback through E-Cadherin Promotes Direction Sensing during Collective Cell Migration

(2014) Danfeng Cai et al.   CELL

How to Measure Molecular Forces in Cells: A Guide to Evaluating Genetically-Encoded FRET-Based Tension Sensors

(2014) Anna-Lena Cost et al.   Cellular and Molecular Bioengineering

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Mechanical control of the sense of touch by β-spectrin

(2014) Michael Krieg et al.   NATURE CELL BIOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

A DNA-based molecular probe for optically reporting cellular traction forces

(2014) Brandon L Blakely et al.   NATURE METHODS

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Mechanics in Neuronal Development and Repair

(2013) Kristian Franze et al.   Annual Review of Biomedical Engineering

The Yin-Yang of Rigidity Sensing: How Forces and Mechanical Properties Regulate the Cellular Response to Materials

(2013) Ingmar Schoen et al.   Annual Review of Materials Research

Fluorescence-Based Force/Tension Sensors: A Novel Tool to Visualize Mechanical Forces in Structural Proteins in Live Cells

(2013) Jun Guo et al.   ANTIOXIDANTS & REDOX SIGNALING

Forces in Tissue Morphogenesis and Patterning

(2013) Carl-Philipp Heisenberg et al.   CELL

Fluid Shear Stress on Endothelial Cells Modulates Mechanical Tension across VE-Cadherin and PECAM-1

(2013) Daniel E. Conway et al.   CURRENT BIOLOGY

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

(2013) Alex Carisey et al.   CURRENT BIOLOGY

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy

(2013) G. Zoldak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How vinculin regulates force transmission

(2013) D. W. Dumbauld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

New isoform-specific monoclonal antibodies reveal different sub-cellular localisations for talin1 and talin2

(2012) Uta Praekelt et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

E-cadherin is under constitutive actomyosin-generated tension that is increased at cell-cell contacts upon externally applied stretch

(2012) N. Borghi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Auto- and cross-power spectral analysis of dual trap optical tweezer experiments using Bayesian inference

(2012) Yann von Hansen et al.   REVIEW OF SCIENTIFIC INSTRUMENTS

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

The Complex Folding Network of Single Calmodulin Molecules

(2011) J. Stigler et al.   SCIENCE

Extracellular Matrix Degradation and Remodeling in Development and Disease

(2011) P. Lu et al.   Cold Spring Harbor Perspectives in Biology

Automated segmentation and tracking for large-scale analysis of focal adhesion dynamics

(2010) T. WÜRFLINGER et al.   JOURNAL OF MICROSCOPY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Structural Diversity in Integrin/Talin Interactions

(2010) Nicholas J. Anthis et al.   STRUCTURE

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

(2009) F. J. Conti et al.   DEVELOPMENT

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Protein-DNA chimeras for single molecule mechanical folding studies with the optical tweezers

(2008) Ciro Cecconi et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology

High Resolution Traction Force Microscopy Based on Experimental and Computational Advances

(2007) Benedikt Sabass et al.   BIOPHYSICAL JOURNAL