The integrin adhesome: from genes and proteins to human disease

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Partial Loss of Epithelial Phenotype in Kindlin-1–Deficient Keratinocytes

(2012) Haiyan Qu et al.   AMERICAN JOURNAL OF PATHOLOGY

The ever-expanding spectrum of congenital muscular dystrophies

(2012) Eugenio Mercuri et al.   ANNALS OF NEUROLOGY

Mice carrying a complete deletion of the talin2 coding sequence are viable and fertile

(2012) Emmanuel Debrand et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ZEB2 upregulates integrin α5 expression through cooperation with Sp1 to induce invasion during epithelial–mesenchymal transition of human cancer cells

(2012) Eun-Hee Nam et al.   CARCINOGENESIS

Opening the floodgates: proteomics and the integrin adhesome

(2012) Tamar Geiger et al.   CURRENT OPINION IN CELL BIOLOGY

Vedolizumab for the treatment of ulcerative colitis and Crohn’s disease

(2012) Leon P McLean et al.   Immunotherapy

Gain of glycosylation in integrin α3 causes lung disease and nephrotic syndrome

(2012) Nayia Nicolaou et al.   JOURNAL OF CLINICAL INVESTIGATION

Podocyte Wnt/ß-catenin pathway is activated by integrin-linked kinase in clinical and experimental focal segmental glomerulosclerosis

(2012) Marcelo A. Naves et al.   JOURNAL OF NEPHROLOGY

ZASPopathy with childhood-onset distal myopathy

(2012) Katharina Strach et al.   JOURNAL OF NEUROLOGY

MYC suppresses cancer metastasis by direct transcriptional silencing of αv and β3 integrin subunits

(2012) Hong Liu et al.   NATURE CELL BIOLOGY

Integrin α3Mutations with Kidney, Lung, and Skin Disease

(2012) Cristina Has et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased Expression of Integrin-Linked Kinase Improves Cardiac Function and Decreases Mortality in Dilated Cardiomyopathy Model of Rats

(2012) Rong Gu et al.   PLoS One

Cell Invasion by Neisseria meningitidis Requires a Functional Interplay between the Focal Adhesion Kinase, Src and Cortactin

(2012) Heiko Slanina et al.   PLoS One

ILK Induces Cardiomyogenesis in the Human Heart

(2012) Alexandra Traister et al.   PLoS One

Enhanced radiosensitivity of head and neck squamous cell carcinoma cells by β1 integrin inhibition

(2012) Iris Eke et al.   RADIOTHERAPY AND ONCOLOGY

Contemporary use of glycoprotein IIb/IIIa inhibitors

(2012) Morten Würtz et al.   THROMBOSIS AND HAEMOSTASIS

Integrins as therapeutic targets

(2012) Simon L. Goodman et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of nephropathy candidate genes by comparing sclerosis-prone and sclerosis-resistant mouse strain kidney transcriptomes

(2012) Ashraf El-Meanawy et al.   BMC Nephrology

Quantitative, High-Resolution Proteomics for Data-Driven Systems Biology

(2011) Jürgen Cox et al.   Annual Review of Biochemistry

Absence of preference for social novelty and increased grooming in integrin β3 knockout mice: Initial studies and future directions

(2011) Michelle D. Carter et al.   Autism Research

Glanzmann thrombasthenia: a review of ITGA2B and ITGB3 defects with emphasis on variants, phenotypic variability, and mouse models

(2011) A. T. Nurden et al.   BLOOD

Oncogenic ILK, tumor suppression and all that JNK

(2011) Adam David Durbin et al.   CELL CYCLE

Monoclonal Antibodies and Recombinant Immunoglobulins for the Treatment of Multiple Sclerosis

(2011) Henrik Gensicke et al.   CNS DRUGS

The role of β3-integrins in tumor angiogenesis: context is everything

(2011) Stephen D Robinson et al.   CURRENT OPINION IN CELL BIOLOGY

microRNA-214 contributes to melanoma tumour progression through suppression of TFAP2C

(2011) Elisa Penna et al.   EMBO JOURNAL

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

(2011) Herbert B Schiller et al.   EMBO REPORTS

miR-124a is frequently down-regulated in glioblastoma and is involved in migration and invasion

(2011) Adam Fowler et al.   EUROPEAN JOURNAL OF CANCER

Integrin-mediated uptake of fibronectin-binding bacteria

(2011) Christine Hoffmann et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

IL-8 increases integrin expression and cell motility in human chondrosarcoma cells

(2011) Chun-Yi Lee et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

IGF-I enhances α5β1 integrin expression and cell motility in human chondrosarcoma cells

(2011) Chi-Ming Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis

(2011) Shreeram Akilesh et al.   JOURNAL OF CLINICAL INVESTIGATION

Tailoring of Integrin Ligands: Probing the Charge Capability of the Metal Ion-Dependent Adhesion Site

(2011) Markus Bollinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reconstructing adhesion structures in tissues by cryo-electron tomography of vitrified frozen sections

(2011) Melanie Bokstad et al.   JOURNAL OF STRUCTURAL BIOLOGY

Activation of RhoA in Podocytes Induces Focal Segmental Glomerulosclerosis

(2011) L. Zhu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Focal adhesion kinase regulation of neovascularization

(2011) Kishore K. Wary et al.   MICROVASCULAR RESEARCH

miR-31 Is a Broad Regulator of  1-Integrin Expression and Function in Cancer Cells

(2011) K. Augoff et al.   MOLECULAR CANCER RESEARCH

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

(2011) Jean-Cheng Kuo et al.   NATURE CELL BIOLOGY

Molecular Architecture and Function of Matrix Adhesions

(2011) B. Geiger et al.   Cold Spring Harbor Perspectives in Biology

Cortactin

(2011) Kellye C. Kirkbride et al.   Cell Adhesion & Migration

Major Host Factors Involved in Epithelial Cell Invasion of Campylobacter jejuni: Role of Fibronectin, Integrin Beta1, FAK, Tiam-1, and DOCK180 in Activating Rho GTPase Rac1

(2011) Manja Boehm et al.   Frontiers in Cellular and Infection Microbiology

Systematic analysis, comparison, and integration of disease based human genetic association data and mouse genetic phenotypic information

(2010) Yonqing Zhang et al.   BMC Medical Genomics

A ZASP Missense Mutation, S196L, Leads to Cytoskeletal and Electrical Abnormalities in a Mouse Model of Cardiomyopathy

(2010) Zhaohui Li et al.   Circulation-Arrhythmia and Electrophysiology

Frontiers of microscopy-based research into cell–matrix adhesions

(2010) Ohad Medalia et al.   CURRENT OPINION IN CELL BIOLOGY

Conditional ablation of integrin alpha-6 in mouse epidermis leads to skin fragility and inflammation

(2010) Cristina Niculescu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell

(2010) Katarzyna Bialkowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The switchable integrin adhesome

(2010) R. Zaidel-Bar et al.   JOURNAL OF CELL SCIENCE

TNF-α increases αvβ3 integrin expression and migration in human chondrosarcoma cells

(2010) Chun-Han Hou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Overview of epidermolysis bullosa

(2010) Daisuke SAWAMURA et al.   JOURNAL OF DERMATOLOGY

Genetic Background Strongly Influences the Severity of Glomerulosclerosis in Mice

(2010) Tomohiro NISHINO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography

(2010) Israel Patla et al.   NATURE CELL BIOLOGY

RNA sequencing: advances, challenges and opportunities

(2010) Fatih Ozsolak et al.   NATURE REVIEWS GENETICS

Decoding signalling networks by mass spectrometry-based proteomics

(2010) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human-Restricted Bacterial Pathogens Block Shedding of Epithelial Cells by Stimulating Integrin Activation

(2010) P. Muenzner et al.   SCIENCE

The role of focal adhesion kinase in tumor initiation and progression

(2010) Paolo P. Provenzano et al.   Cell Adhesion & Migration

Efalizumab

(2009) James E Frampton et al.   AMERICAN JOURNAL OF CLINICAL DERMATOLOGY

FAK mediates the activation of cardiac fibroblasts induced by mechanical stress through regulation of the mTOR complex

(2009) Ana Paula Dalla Costa et al.   CARDIOVASCULAR RESEARCH

Kindler Syndrome Pathogenesis and Fermitin Family Homologue 1 (Kindlin-1) Function

(2009) Maria-Anna M.A. D'Souza et al.   DERMATOLOGIC CLINICS

Alopecia in Epidermolysis Bullosa

(2009) Antonella Tosti et al.   DERMATOLOGIC CLINICS

Molecular mechanism of α2β1 integrin interaction with human echovirus 1

(2009) Johanna Jokinen et al.   EMBO JOURNAL

β2Integrin deficiency yields unconventional double-negative T cells distinct from mature classical natural killer T cells in mice

(2009) Tsvetelina Oreshkova et al.   IMMUNOLOGY

Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown

(2009) Sabina E. Winograd-Katz et al.   JOURNAL OF CELL BIOLOGY

Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment

(2009) Minsoo Kim et al.   NATURE

Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells

(2009) Markus Moser et al.   NATURE MEDICINE

A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans

(2009) Nikolay L Malinin et al.   NATURE MEDICINE

Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation

(2009) Lena Svensson et al.   NATURE MEDICINE

Recurrence of focal segmental glomerular sclerosis (FSGS) after renal transplantation

(2009) C. Ponticelli   NEPHROLOGY DIALYSIS TRANSPLANTATION

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase of Integrin-Linked Kinase Activity in Cultured Podocytes upon Stimulation with Plasma from Patients with Recurrent FSGS

(2008) M. Hattori et al.   AMERICAN JOURNAL OF TRANSPLANTATION

LAD-1/variant syndrome is caused by mutations inFERMT3

(2008) Taco W. Kuijpers et al.   BLOOD

SILAC Mouse for Quantitative Proteomics Uncovers Kindlin-3 as an Essential Factor for Red Blood Cell Function

(2008) Marcus Krüger et al.   CELL

Subversion of CtBP1-controlled macropinocytosis by human adenovirus serotype 3

(2008) Beat Amstutz et al.   EMBO JOURNAL

Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death

(2008) M. Zheng et al.   HUMAN MOLECULAR GENETICS

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

(2008) Kaylene J. Simpson et al.   NATURE CELL BIOLOGY

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin β3 expression is regulated by let-7a miRNA in malignant melanoma

(2008) D W Müller et al.   ONCOGENE

Quantitative Multicolor Compositional Imaging Resolves Molecular Domains in Cell-Matrix Adhesions

(2008) Eli Zamir et al.   PLoS One

Precision proteomics: The case for high resolution and high mass accuracy

(2008) M. Mann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Mapping in Human Disease

(2008) D. Altshuler et al.   SCIENCE

Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction

(2008) Siegfried Ussar et al.   PLoS Genetics

Integrin β1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus

(2007) Keizo Kanasaki et al.   DEVELOPMENTAL BIOLOGY

Deleted in liver cancer-1 (DLC-1): A tumor suppressor not just for liver

(2007) Yi-Chun Liao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY