A talin mutant that impairs talin-integrin binding in platelets decelerates  IIb 3 activation without pathological bleeding

Platelets lacking PIP5KI  have normal integrin activation but impaired cytoskeletal-membrane integrity and adhesion

(2013) Y. Wang et al.   BLOOD

Integrin αIIbβ3

(2013) Kamila Bledzka et al.   CIRCULATION RESEARCH

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Agonist stimulation, talin-1, and kindlin-3 are crucial for αIIbβ3 activation in a human megakaryoblastic cell line, CMK

(2012) Tsuyoshi Nakazawa et al.   EXPERIMENTAL HEMATOLOGY

Rap1-Rac1 Circuits Potentiate Platelet Activation

(2011) Lucia Stefanini et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The kinetics of  IIb 3 activation determines the size and stability of thrombi in mice: implications for antiplatelet therapy

(2010) M. Stolla et al.   BLOOD

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

(2010) Petra M. Kopp et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Recreation of the terminal events in physiological integrin activation

(2010) Feng Ye et al.   JOURNAL OF CELL BIOLOGY

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

The structure of an integrin/talin complex reveals the basis of inside-out signal transduction

(2009) Nicholas J Anthis et al.   EMBO JOURNAL

Structural Determinants of Integrin Binding to the Talin Rod

(2009) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin  IIb 3 in platelets

(2008) S. M. Cifuni et al.   BLOOD

Talin at a glance

(2008) D. R. Critchley et al.   JOURNAL OF CELL SCIENCE