The kindlin family: functions, signaling properties and implications for human disease
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The kindlin family: functions, signaling properties and implications for human disease
Authors
Keywords
-
Journal
JOURNAL OF CELL SCIENCE
Volume 129, Issue 1, Pages 17-27
Publisher
The Company of Biologists
Online
2016-01-04
DOI
10.1242/jcs.161190
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Kindlin-2 interacts with and stabilizes EGFR and is required for EGF-induced breast cancer cell migration
- (2015) Baohui Guo et al. CANCER LETTERS
- Kindlin-2 induced by TGF-β signaling promotes pancreatic ductal adenocarcinoma progression through downregulation of transcriptional factor HOXB9
- (2015) Jun Zhan et al. CANCER LETTERS
- EMMPRIN regulatesβ1 integrin-mediated adhesion through Kindlin-3 in human melanoma cells
- (2015) Julie Delyon et al. EXPERIMENTAL DERMATOLOGY
- Kindlin-3–mediated integrin adhesion is dispensable for quiescent but essential for activated hematopoietic stem cells
- (2015) Raphael Ruppert et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Optimal T Cell Activation and B Cell Antibody Responses In Vivo Require the Interaction between Leukocyte Function–Associated Antigen-1 and Kindlin-3
- (2015) Vicky Louise Morrison et al. JOURNAL OF IMMUNOLOGY
- Kindlin-2: A novel prognostic biomarker for patients with hepatocellular carcinoma
- (2015) Yong-Sheng Ge et al. PATHOLOGY RESEARCH AND PRACTICE
- Expression of Kindlin-1 in human hepatocellular carcinoma and its prognostic significance
- (2015) Hua-Xing Ma et al. TUMOR BIOLOGY
- Kindlin-2 inhibited the growth and migration of colorectal cancer cells
- (2015) Yuanyuan Ren et al. TUMOR BIOLOGY
- A novel tumor suppressor function of Kindlin-3 in solid cancer
- (2015) Ibtissem Djaafri et al. Oncotarget
- Kindlin-2 inhibits serous epithelial ovarian cancer peritoneal dissemination and predicts patient outcomes
- (2014) Caixia Ren et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Kindlin-3 enhances breast cancer progression and metastasis by activating Twist-mediated angiogenesis
- (2014) Khalid Sossey-Alaoui et al. FASEB JOURNAL
- C-terminal COOH of Integrin β1 Is Necessary for β1 Association with the Kindlin-2 Adapter Protein
- (2014) Paul Fitzpatrick et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular Basis of Kindlin-2 Binding to Integrin-linked Kinase Pseudokinase for Regulating Cell Adhesion
- (2014) Koichi Fukuda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Differences in binding to the ILK complex determines kindlin isoform adhesion localization and integrin activation
- (2014) C. Huet-Calderwood et al. JOURNAL OF CELL SCIENCE
- RhoA activation by CNFy restores cell-cell adhesion in kindlin-2-deficient keratinocytes
- (2014) Yinghong He et al. JOURNAL OF PATHOLOGY
- In VivoAssessment of Protease Dynamics in Cutaneous Wound Healing by Degradomics Analysis of Porcine Wound Exudates
- (2014) Fabio Sabino et al. MOLECULAR & CELLULAR PROTEOMICS
- The bone marrow niche for haematopoietic stem cells
- (2014) Sean J. Morrison et al. NATURE
- Kindlin-1 controls Wnt and TGF-β availability to regulate cutaneous stem cell proliferation
- (2014) Emanuel Rognoni et al. NATURE MEDICINE
- Loss of beta2-integrin-mediated cytoskeletal linkage reprogrammes dendritic cells to a mature migratory phenotype
- (2014) Vicky Louise Morrison et al. Nature Communications
- Novel Automated Tracking Analysis of Particles Subjected to Shear Flow: Kindlin-3 Role in B Cells
- (2013) Frances Willenbrock et al. BIOPHYSICAL JOURNAL
- Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism
- (2013) E. Pluskota et al. BLOOD
- The 2 integrin-kindlin-3 interaction is essential for T-cell homing but dispensable for T-cell activation in vivo
- (2013) V. L. Morrison et al. BLOOD
- miR-200b suppresses invasiveness and modulates the cytoskeletal and adhesive machinery in esophageal squamous cell carcinoma cells via targeting Kindlin-2
- (2013) Hai-Feng Zhang et al. CARCINOGENESIS
- The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3
- (2013) Feng Ye et al. CURRENT BIOLOGY
- A feedback regulation between Kindlin-2 and GLI1 in prostate cancer cells
- (2013) Jianchao Gao et al. FEBS LETTERS
- Kindlin 2 promotes breast cancer invasion via epigenetic silencing of the microRNA200 gene family
- (2013) Yu Yu et al. INTERNATIONAL JOURNAL OF CANCER
- Kindlin-1 expression is involved in migration and invasion of pancreatic cancer
- (2013) PRAWEJ MAHAWITHITWONG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Novel focal adhesion protein kindlin-2 promotes the invasion of gastric cancer cells through phosphorylation of integrin β1 and β3
- (2013) Zhanlong Shen et al. JOURNAL OF SURGICAL ONCOLOGY
- Kindlin-2 Mediates Activation of TGF- /Smad Signaling and Renal Fibrosis
- (2013) X. Wei et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- RNAi screens in mice identify physiological regulators of oncogenic growth
- (2013) Slobodan Beronja et al. NATURE
- Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma
- (2013) Prawej Mahawithitwong et al. PANCREAS
- Kindlin 2 Regulates Myogenic Related Factor Myogenin via a Canonical Wnt Signaling in Myogenic Differentiation
- (2013) Yu Yu et al. PLoS One
- Kindlin-1 Regulates Integrin Dynamics and Adhesion Turnover
- (2013) Coert Margadant et al. PLoS One
- Kindlin-3 regulates integrin activation and adhesion reinforcement of effector T cells
- (2013) F. A. Moretti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1
- (2013) Hitesh Patel et al. Nature Communications
- Leukocyte adhesion deficiencies
- (2012) Suhair Hanna et al. Annals of the New York Academy of Sciences
- Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
- (2012) C. T. Lefort et al. BLOOD
- Induction of senescence pathways in Kindler syndrome primary keratinocytes
- (2012) E. Piccinni et al. BRITISH JOURNAL OF DERMATOLOGY
- Kindlin-2 promotes genome instability in breast cancer cells
- (2012) Ting Zhao et al. CANCER LETTERS
- Kindlin 2 forms a transcriptional complex with β-catenin and TCF4 to enhance Wnt signalling
- (2012) Yu Yu et al. EMBO REPORTS
- Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails
- (2012) Kamila Bledzka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Molecular Mechanism for the Requirement of PAT-4 (Integrin-linked Kinase (ILK)) for the Localization of UNC-112 (Kindlin) to Integrin Adhesion Sites
- (2012) Hiroshi Qadota et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Kindlin-3 Mediates Integrin αLβ2 Outside-in Signaling, and It Interacts with Scaffold Protein Receptor for Activated-C Kinase 1 (RACK1)
- (2012) Chen Feng et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Regulation of Cell Adhesion and Migration by Kindlin-3 Cleavage by Calpain
- (2012) Yongzhong Zhao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Comparative phenotypic analysis of the two major splice isoforms of phosphatidylinositol phosphate kinase type I in vivo
- (2012) K. R. Legate et al. JOURNAL OF CELL SCIENCE
- Functional differences between kindlin-1 and kindlin-2 in keratinocytes
- (2012) A. Bandyopadhyay et al. JOURNAL OF CELL SCIENCE
- Proteomic Cornerstones of Hematopoietic Stem Cell Differentiation: Distinct Signatures of Multipotent Progenitors and Myeloid Committed Cells
- (2012) Daniel Klimmeck et al. MOLECULAR & CELLULAR PROTEOMICS
- Sorting nexin 17 prevents lysosomal degradation of β1 integrins by binding to the β1-integrin tail
- (2012) Ralph Thomas Böttcher et al. NATURE CELL BIOLOGY
- Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
- (2012) Jun Zhan et al. PLoS One
- Kindlin-1 and -2 Have Overlapping Functions in Epithelial Cells
- (2011) Yinghong He et al. AMERICAN JOURNAL OF PATHOLOGY
- Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer
- (2011) Zhanlong Shen et al. AMERICAN JOURNAL OF SURGERY
- The integrin coactivator Kindlin-2 plays a critical role in angiogenesis in mice and zebrafish
- (2011) E. Pluskota et al. BLOOD
- SnapShot: Hair Follicle Stem Cells
- (2011) Wei-Meng Woo et al. CELL
- Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
- (2011) Piul Rabbani et al. CELL
- Nonmyelinating Schwann Cells Maintain Hematopoietic Stem Cell Hibernation in the Bone Marrow Niche
- (2011) Satoshi Yamazaki et al. CELL
- Inherited epidermolysis bullosa: New diagnostic criteria and classification
- (2011) Lizbeth R.A. Intong et al. CLINICS IN DERMATOLOGY
- Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
- (2011) Ammad Aslam Khan et al. Evolutionary Bioinformatics
- Kindler syndrome: Extension of FERMT1 mutational spectrum and natural history
- (2011) Cristina Has et al. HUMAN MUTATION
- Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption
- (2011) Sarah Schmidt et al. JOURNAL OF CELL BIOLOGY
- Kindlin-2 regulates podocyte adhesion and fibronectin matrix deposition through interactions with phosphoinositides and integrins
- (2011) H. Qu et al. JOURNAL OF CELL SCIENCE
- Role of the Focal Adhesion Protein Kindlin-1 in Breast Cancer Growth and Lung Metastasis
- (2011) Soraya Sin et al. JNCI-Journal of the National Cancer Institute
- 1 integrin cytoplasmic tyrosines promote skin tumorigenesis independent of their phosphorylation
- (2011) A. Meves et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Kindlin-2 Expression in Arsenite- and Cadmium-transformed Bladder Cancer Cell Lines and in Archival Specimens of Human Bladder Cancer
- (2011) Sherine Talaat et al. UROLOGY
- Kindlin-2 controls sensitivity of prostate cancer cells to cisplatin-induced cell death
- (2010) Xiaowei Gong et al. CANCER LETTERS
- Key Roles for Transforming Growth Factor β in Melanocyte Stem Cell Maintenance
- (2010) Emi K. Nishimura et al. Cell Stem Cell
- Kindlin-2 is expressed in malignant mesothelioma and is required for tumor cell adhesion and migration
- (2010) Zhengwen An et al. INTERNATIONAL JOURNAL OF CANCER
- Tyrosine Phosphorylation of Integrin β3Regulates Kindlin-2 Binding and Integrin Activation
- (2010) Kamila Bledzka et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Integrin Co-activator Kindlin-3 Is Expressed and Functional in a Non-hematopoietic Cell, the Endothelial Cell
- (2010) Katarzyna Bialkowska et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans
- (2010) Bernhard Bielesz et al. JOURNAL OF CLINICAL INVESTIGATION
- Role of Kindlin-2 in Fibroblast Functions: Implications for Wound Healing
- (2010) Yinghong He et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- The final steps of integrin activation: the end game
- (2010) Sanford J. Shattil et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Loss-of-Function FERMT1 Mutations in Kindler Syndrome Implicate a Role for Fermitin Family Homolog-1 in Integrin Activation
- (2009) Joey E. Lai-Cheong et al. AMERICAN JOURNAL OF PATHOLOGY
- The role of kindlins in cell biology and relevance to human disease
- (2009) J.E. Lai-Cheong et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- The tale of transforming growth factor-beta (TGFβ) signaling: A soigné enigma
- (2009) Arindam Chaudhury et al. IUBMB LIFE
- Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects
- (2009) David S. Harburger et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Integrin αIIbβ3 Activation in Chinese Hamster Ovary Cells and Platelets Increases Clustering Rather than Affinity
- (2009) Thomas A. Bunch JOURNAL OF BIOLOGICAL CHEMISTRY
- Kindlin-3 is required for β2 integrin–mediated leukocyte adhesion to endothelial cells
- (2009) Markus Moser et al. NATURE MEDICINE
- A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans
- (2009) Nikolay L Malinin et al. NATURE MEDICINE
- Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation
- (2009) Lena Svensson et al. NATURE MEDICINE
- The Tail of Integrins, Talin, and Kindlins
- (2009) M. Moser et al. SCIENCE
- LAD-1/variant syndrome is caused by mutations inFERMT3
- (2008) Taco W. Kuijpers et al. BLOOD
- Kindlin-3: a new gene involved in the pathogenesis of LAD-III
- (2008) A. Mory et al. BLOOD
- Kindlin-2 is required for myocyte elongation and is essential for myogenesis
- (2008) James J Dowling et al. BMC CELL BIOLOGY
- TGFβ in Cancer
- (2008) Joan Massagué CELL
- Kindlin-2 Is an Essential Component of Intercalated Discs and Is Required for Vertebrate Cardiac Structure and Function
- (2008) James J. Dowling et al. CIRCULATION RESEARCH
- RNA interference screening in Drosophila primary cells for genes involved in muscle assembly and maintenance
- (2008) J. Bai et al. DEVELOPMENT
- Integrin Trafficking Regulated by Rab21 Is Necessary for Cytokinesis
- (2008) Teijo Pellinen et al. DEVELOPMENTAL CELL
- Kindlin-2 controls bidirectional signaling of integrins
- (2008) E. Montanez et al. GENES & DEVELOPMENT
- Kindlin-2 (Mig-2): a co-activator of β3integrins
- (2008) Yan-Qing Ma et al. JOURNAL OF CELL BIOLOGY
- Skin stem cells: rising to the surface
- (2008) Elaine Fuchs JOURNAL OF CELL BIOLOGY
- Colocalization of Kindlin-1, Kindlin-2, and Migfilin at Keratinocyte Focal Adhesion and Relevance to the Pathophysiology of Kindler Syndrome
- (2008) J.E. Lai-Cheong et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- A Suppressive Role of Mitogen Inducible Gene-2 in Mesenchymal Cancer Cell Invasion
- (2008) X. Shi et al. MOLECULAR CANCER RESEARCH
- Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling
- (2008) Ilaria Malanchi et al. NATURE
- Kindlin-3 is essential for integrin activation and platelet aggregation
- (2008) Markus Moser et al. NATURE MEDICINE
- Loss of Kindlin-1 Causes Skin Atrophy and Lethal Neonatal Intestinal Epithelial Dysfunction
- (2008) Siegfried Ussar et al. PLoS Genetics
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now