Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Titin-Based Nanoparticle Tension Sensors Map High-Magnitude Integrin Forces within Focal Adhesions

(2015) Kornelia Galior et al.   NANO LETTERS

Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration

(2015) Frederic Lagarrigue et al.   Nature Communications

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Traction force microscopy in physics and biology

(2014) Robert W. Style et al.   Soft Matter

The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry

(2013) Qingsen Li et al.   BIOMATERIALS

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cadherin-based intercellular adhesions organize epithelial cell-matrix traction forces

(2013) A. F. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Single Molecular Forces Required to Activate Integrin and Notch Signaling

(2013) X. Wang et al.   SCIENCE

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Biophysical signals controlling cell fate decisions: How do stem cells really feel?

(2012) Patricia Costa et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Scaling of Traction Forces with the Size of Cohesive Cell Colonies

(2012) Aaron F. Mertz et al.   PHYSICAL REVIEW LETTERS

Actin cap associated focal adhesions and their distinct role in cellular mechanosensing

(2012) Dong-Hwee Kim et al.   Scientific Reports

Structure and function of focal adhesions

(2011) Bernhard Wehrle-Haller   CURRENT OPINION IN CELL BIOLOGY

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Measurements of Elastic Moduli of Silicone Gel Substrates with a Microfluidic Device

(2011) Edgar Gutierrez et al.   PLoS One

Distinct developmental roles for direct and indirect talin-mediated linkage to actin

(2010) Ari Franco-Cea et al.   DEVELOPMENTAL BIOLOGY

Studies on the morphology and spreading of human endothelial cells define key inter- and intramolecular interactions for talin1

(2010) Petra M. Kopp et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

(2010) Ana M. Pasapera et al.   JOURNAL OF CELL BIOLOGY

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

The mechanical integrin cycle

(2009) E. Puklin-Faucher et al.   JOURNAL OF CELL SCIENCE

Integrin connections to the cytoskeleton through talin and vinculin

(2008) Wolfgang H. Ziegler et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner

(2008) H. Hirata et al.   JOURNAL OF CELL SCIENCE

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Structural model and functional significance of pH-dependent talin-actin binding for focal adhesion remodeling

(2008) J. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE