The mechanical response of talin

Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity

(2016) Abhishek Kumar et al.   JOURNAL OF CELL BIOLOGY

Vinculin and Talin

(2016) Alice Zemljic-Harpf et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Dynamics of Equilibrium Folding and Unfolding Transitions of Titin Immunoglobulin Domain under Constant Forces

(2015) Hu Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Vinculin controls talin engagement with the actomyosin machinery

(2015) Paul Atherton et al.   Nature Communications

Talin Dependent Mechanosensitivity of Cell Focal Adhesions

(2014) Jie Yan et al.   Cellular and Molecular Bioengineering

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

(2014) Matthew J. Paszek et al.   NATURE

Actomyosin-dependent formation of the mechanosensitive talin–vinculin complex reinforces actin anchoring

(2014) Corina Ciobanasu et al.   Nature Communications

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

Talin Autoinhibition Is Required for Morphogenesis

(2013) Stephanie J. Ellis et al.   CURRENT BIOLOGY

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

(2013) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural studies on full-length talin1 reveal a compact auto-inhibited dimer: Implications for talin activation

(2013) Benjamin T. Goult et al.   JOURNAL OF STRUCTURAL BIOLOGY

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

(2012) Neil Bate et al.   PLoS One

Improved High-Force Magnetic Tweezers for Stretching and Refolding of Proteins and Short DNA

(2011) Hu Chen et al.   BIOPHYSICAL JOURNAL

Differential Mechanical Stability of Filamin A Rod Segments

(2011) Hu Chen et al.   BIOPHYSICAL JOURNAL

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

Central Region of Talin Has a Unique Fold That Binds Vinculin and Actin

(2010) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Biochemical and Structural Properties of the Integrin-Associated Cytoskeletal Protein Talin

(2009) David R. Critchley   Annual Review of Biophysics

Structural Determinants of Integrin Binding to the Talin Rod

(2009) Alexandre R. Gingras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of an Interdomain Complex That Regulates Talin Activity

(2009) Benjamin T. Goult et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

How Force Might Activate Talin's Vinculin Binding Sites: SMD Reveals a Structural Mechanism

(2008) Vesa P. Hytönen et al.   PLoS Computational Biology