Mechanical regulation of a molecular clutch defines force transmission and transduction in response to matrix rigidity

Alternative Mechanisms for Talin to Mediate Integrin Function

(2015) Benjamin Klapholz et al.   CURRENT BIOLOGY

Regulation of integrin-mediated adhesions

(2015) Daniel V Iwamoto et al.   CURRENT OPINION IN CELL BIOLOGY

Molecular mechanism of vinculin activation and nanoscale spatial organization in focal adhesions

(2015) Lindsay B. Case et al.   NATURE CELL BIOLOGY

Extracellular rigidity sensing by talin isoform-specific mechanical linkages

(2015) Katharina Austen et al.   NATURE CELL BIOLOGY

Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex

(2015) Jocelyn Étienne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disease implications of the Hippo/YAP pathway

(2015) Steven W. Plouffe et al.   TRENDS IN MOLECULAR MEDICINE

Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing

(2015) Mukund Gupta et al.   Nature Communications

Force-dependent vinculin binding to talin in live cells: a crucial step in anchoring the actin cytoskeleton to focal adhesions

(2014) Hiroaki Hirata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Geometry Regulates Traction Stresses in Adherent Cells

(2014) Patrick W. Oakes et al.   BIOPHYSICAL JOURNAL

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Image Analysis for the Quantitative Comparison of Stress Fibers and Focal Adhesions

(2014) Alberto Elosegui-Artola et al.   PLoS One

Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation

(2014) Mingxi Yao et al.   Scientific Reports

The Yin-Yang of Rigidity Sensing: How Forces and Mechanical Properties Regulate the Cellular Response to Materials

(2013) Ingmar Schoen et al.   Annual Review of Materials Research

Determinants of Maximal Force Transmission in a Motor-Clutch Model of Cell Traction in a Compliant Microenvironment

(2013) Benjamin L. Bangasser et al.   BIOPHYSICAL JOURNAL

Master Equation-Based Analysis of a Motor-Clutch Model for Cell Traction Force

(2013) Benjamin L. Bangasser et al.   Cellular and Molecular Bioengineering

Vinculin–actin interaction couples actin retrograde flow to focal adhesions, but is dispensable for focal adhesion growth

(2013) Ingo Thievessen et al.   JOURNAL OF CELL BIOLOGY

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Integrin-dependent force transmission to the extracellular matrix by  -actinin triggers adhesion maturation

(2013) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Force Fluctuations within Focal Adhesions Mediate ECM-Rigidity Sensing to Guide Directed Cell Migration

(2012) Sergey V. Plotnikov et al.   CELL

Finding the weakest link – exploring integrin-mediated mechanical molecular pathways

(2012) Pere Roca-Cusachs et al.   JOURNAL OF CELL SCIENCE

Mechanical waves during tissue expansion

(2012) Xavier Serra-Picamal et al.   Nature Physics

Talin Contains A C-Terminal Calpain2 Cleavage Site Important In Focal Adhesion Dynamics

(2012) Neil Bate et al.   PLoS One

Cells test substrate rigidity by local contractions on submicrometer pillars

(2012) S. Ghassemi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction In Vivo by Repeated Talin Stretch-Relaxation Events Depends upon Vinculin

(2011) Felix Margadant et al.   PLOS BIOLOGY

Substrate Stiffness and Cell Area Predict Cellular Traction Stresses in Single Cells and Cells in Contact

(2010) Joseph P. Califano et al.   Cellular and Molecular Bioengineering

Stretchy Proteins on Stretchy Substrates: The Important Elements of Integrin-Mediated Rigidity Sensing

(2010) Simon W. Moore et al.   DEVELOPMENTAL CELL

Forcing Switch from Short- to Intermediate- and Long-lived States of the αA Domain Generates LFA-1/ICAM-1 Catch Bonds

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New PI(4,5)P2- and membrane proximal integrin–binding motifs in the talin head control β3-integrin clustering

(2009) Frédéric Saltel et al.   JOURNAL OF CELL BIOLOGY

Demonstration of catch bonds between an integrin and its ligand

(2009) Fang Kong et al.   JOURNAL OF CELL BIOLOGY

Clustering of  5 1 integrins determines adhesion strength whereas  v 3 and talin enable mechanotransduction

(2009) P. Roca-Cusachs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Micropatterning of Single Endothelial Cell Shape Reveals a Tight Coupling between Nuclear Volume in G1 and Proliferation

(2008) Pere Roca-Cusachs et al.   BIOPHYSICAL JOURNAL

Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods

(2008) Wei Chen et al.   Cellular and Molecular Bioengineering

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE

Traction forces and rigidity sensing regulate cell functions

(2008) Marion Ghibaudo et al.   Soft Matter