SHANK proteins limit integrin activation by directly interacting with Rap1 and R-Ras

Direct Interaction between TalinB and Rap1 is necessary for adhesion of Dictyostelium cells

(2016) Katarzyna Plak et al.   BMC CELL BIOLOGY

Adult restoration of Shank3 expression rescues selective autistic-like phenotypes

(2016) Yuan Mei et al.   NATURE

CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency

(2016) Michael Bidinosti et al.   SCIENCE

OSBP-related protein 3 (ORP3) coupling with VAMP-associated protein A regulates R-Ras activity

(2015) Marion Weber-Boyvat et al.   EXPERIMENTAL CELL RESEARCH

Integrin endosomal signalling suppresses anoikis

(2015) Jonna Alanko et al.   NATURE CELL BIOLOGY

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

(2015) Lara J. Duffney et al.   Cell Reports

Mutually Exclusive Roles of SHARPIN in Integrin Inactivation and NF-κB Signaling

(2015) Nicola De Franceschi et al.   PLoS One

The PSD protein ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia-associated mutation

(2014) Stefanie Grabrucker et al.   EXPERIMENTAL NEUROLOGY

Clinical and genomic evaluation of 201 patients with Phelan–McDermid syndrome

(2014) Sara M. Sarasua et al.   HUMAN GENETICS

Talin1 phosphorylation activates β1 integrins: a novel mechanism to promote prostate cancer bone metastasis

(2014) J-K Jin et al.   ONCOGENE

Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood

(2014) Aaron D. Levy et al.   Frontiers in Neuroanatomy

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice

(2014) Xiaoming Wang et al.   Molecular Autism

A blueprint for research on Shankopathies: A view from research on autism spectrum disorder

(2013) Salvatore Carbonetto   Developmental Neurobiology

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

SHANK3Gene Mutations Associated with Autism Facilitate Ligand Binding to the Shank3 Ankyrin Repeat Region

(2013) Marie Germaine Mameza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1–IQGAP1 complex

(2013) Guillaume Jacquemet et al.   JOURNAL OF CELL BIOLOGY

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

(2013) Kihoon Han et al.   NATURE

Talins and kindlins: partners in integrin-mediated adhesion

(2013) David A. Calderwood et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrin inactivators: balancing cellular functions in vitro and in vivo

(2013) Daniel Bouvard et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular mechanisms of dendrite stability

(2013) Anthony J. Koleske   NATURE REVIEWS NEUROSCIENCE

SHARPIN Regulates Uropod Detachment in Migrating Lymphocytes

(2013) Jeroen Pouwels et al.   Cell Reports

SHANK3 haploinsufficiency: a “common” but underdiagnosed highly penetrant monogenic cause of autism spectrum disorders

(2013) Catalina Betancur et al.   Molecular Autism

A functional genetic screen reveals new regulators of  1-integrin activity

(2012) T. Pellinen et al.   JOURNAL OF CELL SCIENCE

Autism-Associated Mutations in ProSAP2/Shank3 Impair Synaptic Transmission and Neurexin-Neuroligin-Mediated Transsynaptic Signaling

(2012) M. H. Arons et al.   JOURNAL OF NEUROSCIENCE

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Focal Adhesion Kinase Promotes Integrin Adhesion Dynamics Necessary for Chemotropic Turning of Nerve Growth Cones

(2011) J. P. Myers et al.   JOURNAL OF NEUROSCIENCE

SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism

(2011) C M Durand et al.   MOLECULAR PSYCHIATRY

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

RGMa modulates T cell responses and is involved in autoimmune encephalomyelitis

(2011) Rieko Muramatsu et al.   NATURE MEDICINE

Requirement for Plk2 in Orchestrated Ras and Rap Signaling, Homeostatic Structural Plasticity, and Memory

(2011) Kea Joo Lee et al.   NEURON

High-Resolution Quantification of Focal Adhesion Spatiotemporal Dynamics in Living Cells

(2011) Mathew E. Berginski et al.   PLoS One

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

Mammary-derived growth inhibitor (MDGI) interacts with integrin α-subunits and suppresses integrin activity and invasion

(2010) J Nevo et al.   ONCOGENE

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structure of the Talin Head Reveals a Novel Extended Conformation of the FERM Domain

(2010) Paul R. Elliott et al.   STRUCTURE

Kindlin-1 and -2 Directly Bind the C-terminal Region of β Integrin Cytoplasmic Tails and Exert Integrin-specific Activation Effects

(2009) David S. Harburger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic changes in Rap1 activity are required for cell retraction and spreading during mitosis

(2009) V. T. Dao et al.   JOURNAL OF CELL SCIENCE

Simple and rapid process for single cell micro-patterning

(2009) Ammar Azioune et al.   LAB ON A CHIP

Novel de novo SHANK3 mutation in autistic patients

(2008) Julie Gauthier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments

(2008) Patrick T. Caswell et al.   JOURNAL OF CELL BIOLOGY

The R-Ras interaction partner ORP3 regulates cell adhesion

(2008) M. Lehto et al.   JOURNAL OF CELL SCIENCE

Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro

(2008) Stefan Plantman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE