Research progress on branched-chain amino acid aminotransferases

Effects of the addition of leucine on flavor and quality of sausage fermented by Lactobacillus fermentum YZU-06 and Staphylococcus saprophyticus CGMCC 3475

(2023) Rui Liu et al.   Frontiers in Microbiology

Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism‐Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu

(2023) Guangyu Hu et al.   Advanced Science

Identification of 14 Differentially-Expressed Metabolism-Related Genes as Potential Targets of Gastric Cancer by Integrated Proteomics and Transcriptomics

(2022) Yongxin Zhang et al.   Frontiers in Cell and Developmental Biology

Regulation of the Leucine Metabolism in Mortierella alpina

(2022) Robin Sonnabend et al.   Journal of Fungi

Targeting BCAT1 combined with α-ketoglutarate triggers metabolic synthetic lethality in glioblastoma

(2022) Bo Zhang et al.   CANCER RESEARCH

The Critical Role of the Branched Chain Amino Acids (BCAAs) Catabolism-Regulating Enzymes, Branched-Chain Aminotransferase (BCAT) and Branched-Chain α-Keto Acid Dehydrogenase (BCKD), in Human Pathophysiology

(2022) Aikaterini Dimou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of inhibitors against mycobacterium branched‐chain amino acid aminotransferases through in silico screening and experimental evaluation

(2022) M.T. Pham et al.   LETTERS IN APPLIED MICROBIOLOGY

Circular RNA VPS18 Promotes Glioblastoma Progression by Regulating miR-1229-3p/BCAT1 Axis

(2022) Qianliang Huang et al.   NEUROTOXICITY RESEARCH

Small Molecule Inhibitors in Adult High-Grade Glioma: From the Past to the Future

(2022) Wenda Huang et al.   Frontiers in Oncology

Characterization of a lactic acid bacteria using branched-chain amino acid transaminase and protease from Jinhua Ham and application in myofibrillar protein model

(2022) Rui Liu et al.   MEAT SCIENCE

BCAT1 redox function maintains mitotic fidelity

(2022) Liliana Francois et al.   Cell Reports

BCATc inhibitor 2 ameliorated mitochondrial dysfunction and apoptosis in oleic acid-induced non-alcoholic fatty liver disease model

(2022) Zhuo Lu et al.   Frontiers in Pharmacology

BCAT1, as a prognostic factor for HCC, can promote the development of liver cancer through activation of the AKT signaling pathway and EMT

(2022) Yifeng Ding et al.   JOURNAL OF MOLECULAR HISTOLOGY

DROUGHT-INDUCED BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE enhances drought tolerance in rice

(2022) Jae Sung Shim et al.   PLANT PHYSIOLOGY

Branched-chain amino acid transaminase 1 inhibition attenuates childhood asthma in mice by effecting airway remodeling and autophagy

(2022) Jing Li et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Evaluation of therapeutic strategies targeting BCAA catabolism using a systems pharmacology model

(2022) Veronika Voronova et al.   Frontiers in Pharmacology

Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

(2021) Li Yi et al.   Aging-US

Oxoeicosanoid receptor inhibition alleviates acute myocardial infarction through activation of BCAT1

(2021) Qiong Lai et al.   BASIC RESEARCH IN CARDIOLOGY

System Xc−: a key regulatory target of ferroptosis in cancer

(2021) Man-ru Liu et al.   INVESTIGATIONAL NEW DRUGS

Chronically elevated branched chain amino acid levels are pro-arrhythmic

(2021) Vincent Portero et al.   CARDIOVASCULAR RESEARCH

Branched-chain amino acid metabolism is regulated by ERRα in primary human myotubes and is further impaired by glucose loading in type 2 diabetes

(2021) Rasmus J. O. Sjögren et al.   DIABETOLOGIA

Long non‐coding RNA TMPO‐AS1 facilitates the progression of colorectal cancer cells via sponging miR‐98‐5p to upregulate BCAT1 expression

(2021) Jinjun Ye et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Duplication and Functional Divergence of Branched-Chain Amino Acid Biosynthesis Genes in Aspergillus nidulans

(2021) Joel T. Steyer et al.   mBio

Detection of Circulating Tumor DNA Methylation in Diagnosis of Colorectal Cancer

(2021) Fei Xu et al.   Clinical and Translational Gastroenterology

An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human

(2021) Yoichi Toyokawa et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The Branched-chain Amino Acid Transaminase 1 -23C/G Polymorphism Confers Protection Against Acute Coronary Syndrome

(2020) Julian Ramírez-Bello et al.   Revista de Investigacion Clinica-Clinical and Translational Investigation

BCAT1 Overexpression Promotes Proliferation, Invasion, and Wnt Signaling in Non-Small Cell Lung Cancers

(2020) Xiumin Lin et al.   OncoTargets and Therapy

Identification of m6A-related genes and m6A RNA methylation regulators in pancreatic cancer and their association with survival

(2020) Yan Geng et al.   Annals of Translational Medicine

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

(2020) Kang Wang et al.   CELL DEATH AND DIFFERENTIATION

BCAT1 binds the RNA-binding protein ZNF423 to activate autophagy via the IRE1-XBP-1-RIDD axis in hypoxic PASMCs

(2020) Wei Xin et al.   Cell Death & Disease

Branched-chain amino acid aminotransferase-1 regulates self-renewal and pluripotency of mouse embryonic stem cells through Ras signaling

(2020) Shaohui Chen et al.   Stem Cell Research

Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression

(2019) Russell E. Ericksen et al.   Cell Metabolism

Novel Blood Biomarkers that Correlate with Cognitive Performance and Hippocampal Volumetry: Potential for Early Diagnosis of Alzheimer’s Disease

(2019) Fred Hudd et al.   JOURNAL OF ALZHEIMERS DISEASE

Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1

(2019) Diana Antunes et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Leucine biosynthesis is required for infection-related morphogenesis and pathogenicity in the rice blast fungus Magnaporthe oryzae

(2019) Yawei Que et al.   CURRENT GENETICS

Expanding the genetic and phenotypic spectrum of branched‐chain amino acid transferase 2 deficiency

(2019) Ina Knerr et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Biochemical and structural characterization of a highly active branched-chain amino acid aminotransferase from Pseudomonas sp. for efficient biosynthesis of chiral amino acids

(2019) Xinxin Zheng et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Branched-chain amino acids sustain pancreatic cancer growth by regulating lipid metabolism

(2019) Ji Hyeon Lee et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Metabolic engineering of Escherichia coli for d-pantothenic acid production

(2019) Bo Zhang et al.   FOOD CHEMISTRY

The Effects of BCAAs on Insulin Resistance in Athletes

(2019) Jian SHOU et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

(2018) Huajie Li et al.   BIOSCIENCE REPORTS

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Adverse Childhood Experiences, Epigenetic Measures, and Obesity in Youth

(2018) Joan Kaufman et al.   JOURNAL OF PEDIATRICS

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study

(2018) Kara Wegermann et al.   PLoS One

Gabapentin Can Suppress Cell Proliferation Independent of the Cytosolic Branched-Chain Amino Acid Transferase 1 (BCAT1)

(2018) Nina Grankvist et al.   BIOCHEMISTRY

A Novel highly thermostable branched-chain amino acid aminotransferase from the crenarchaeon Vulcanisaeta moutnovskia

(2017) Tatiana N. Stekhanova et al.   ENZYME AND MICROBIAL TECHNOLOGY

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes

(2017) Adriana Espinosa-Cantú et al.   GENETICS

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes

(2017) Adriana Espinosa-Cantú et al.   GENETICS

Transcriptional hallmarks of cancer cell lines reveal an emerging role of branched chain amino acid catabolism

(2017) Ieva Antanavičiūtė et al.   Scientific Reports

Experimental and computational studies on the unusual substrate specificity of branched-chain amino acid aminotransferase from Thermoproteus uzoniensis

(2016) Ekaterina Yu. Bezsudnova et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chemical Mechanism of the Branched-Chain Aminotransferase IlvE from Mycobacterium tuberculosis

(2016) Tathyana M. Amorim Franco et al.   BIOCHEMISTRY

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia

(2016) Emma L. Ashby et al.   NEUROCHEMICAL RESEARCH

A subfamily of PLP-dependent enzymes specialized in handling terminal amines

(2015) Davide Schiroli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene

(2015) X. L. Wang et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Branched-chain amino acid catabolism is a conserved regulator of physiological ageing

(2015) Johannes Mansfeld et al.   Nature Communications

Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae

(2015) Joanne M. Kingsbury et al.   PLoS Genetics

Cytosolic Branched Chain Aminotransferase (BCATc) Regulates mTORC1 Signaling and Glycolytic Metabolism in CD4+T Cells

(2014) Elitsa A. Ananieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The feasibility of assessing branched-chain amino acid metabolism in cellular models of prostate cancer with hyperpolarized [1-13C]-ketoisocaproate

(2014) Kelvin L. Billingsley et al.   MAGNETIC RESONANCE IMAGING

Effects of Leucine Supplementation and Serum Withdrawal on Branched-Chain Amino Acid Pathway Gene and Protein Expression in Mouse Adipocytes

(2014) Abderrazak Kitsy et al.   PLoS One

An overview of amines as nutritional supplements to counteract cancer cachexia

(2014) Patrícia Lopes de Campos-Ferraz et al.   Journal of Cachexia Sarcopenia and Muscle

The specificity and kinetic mechanism of branched-chain amino acid aminotransferase fromEscherichia colistudied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis

(2013) Xuejing Yu et al.   FEBS Journal

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

Genome-Wide Analysis of Branched-Chain Amino Acid Levels in Arabidopsis Seeds

(2013) R. Angelovici et al.   PLANT CELL

Identifying Candidate Genes for Type 2 Diabetes Mellitus and Obesity through Gene Expression Profiling in Multiple Tissues or Cells

(2013) Junhui Chen et al.   Journal of Diabetes Research

The Branched-Chain Amino Acid Aminotransferase Encoded by ilvE Is Involved in Acid Tolerance in Streptococcus mutans

(2012) B. Santiago et al.   JOURNAL OF BACTERIOLOGY

Biosynthesis of branched-chain amino acids is essential for effective symbioses between betarhizobia and Mimosa pudica

(2012) W.-M. Chen et al.   MICROBIOLOGY-SGM

Impaired branched chain amino acid metabolism alters feeding behavior and increases orexigenic neuropeptide expression in the hypothalamus

(2011) Megan N Purpera et al.   JOURNAL OF ENDOCRINOLOGY

Catabolism of Branched Chain Amino Acids Supports Respiration but Not Volatile Synthesis in Tomato Fruits

(2011) Andrej Kochevenko et al.   Molecular Plant

Mechanism of De Novo Branched-Chain Amino Acid Synthesis as an Alternative Electron Sink in Hypoxic Aspergillus nidulans Cells

(2010) M. Shimizu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Branched-chain and aromatic amino acid catabolism into aroma volatiles in Cucumis melo L. fruit

(2010) Itay Gonda et al.   JOURNAL OF EXPERIMENTAL BOTANY

Characterization of the Branched-Chain Amino Acid Aminotransferase Enzyme Family in Tomato

(2010) G. S. Maloney et al.   PLANT PHYSIOLOGY

The 1.9 Å structure of the branched-chain amino-acid transaminase (IlvE) fromMycobacterium tuberculosis

(2009) L. W. Tremblay et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Branched-chain Amino Acid Metabolon

(2009) Mohammad Mainul Islam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY