An overview of branched-chain amino acid aminotransferases: functional differences between mitochondrial and cytosolic isozymes in yeast and human

BCAT1 overexpression regulates proliferation and c‑Myc/GLUT1 signaling in head and neck squamous cell carcinoma

(2021) Hongming Wang et al.   ONCOLOGY REPORTS

BCAT1 decreases the sensitivity of cancer cells to cisplatin by regulating mTOR-mediated autophagy via branched-chain amino acid metabolism

(2021) Lifang Luo et al.   Cell Death & Disease

Regulation of branched-chain amino acid metabolism by hypoxia-inducible factor in glioblastoma

(2020) Bo Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease

(2020) M. Harris et al.   FREE RADICAL BIOLOGY AND MEDICINE

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

(2020) Jin-Tao Li et al.   NATURE CELL BIOLOGY

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Mitochondrial Compartmentalization Confers Specificity to the 2-Ketoacid Recursive Pathway: Increasing Isopentanol Production in Saccharomyces cerevisiae

(2020) Sarah K. Hammer et al.   ACS Synthetic Biology

Identification of eight novel mutations in 11 Chinese patients with maple syrup urine disease

(2020) Wei-Hua Sun et al.   World Journal of Pediatrics

Effect of the Ala234Asp replacement in mitochondrial branched-chain amino acid aminotransferase on the production of BCAAs and fusel alcohols in yeast

(2020) Jirasin Koonthongkaew et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer

(2020) Yu Song et al.   BMC CANCER

Branched-chain amino acid aminotransferase 2 regulates ferroptotic cell death in cancer cells

(2020) Kang Wang et al.   CELL DEATH AND DIFFERENTIATION

Differential expression of the BCAT isoforms between breast cancer subtypes

(2020) Mai Ahmed Shafei et al.   Breast Cancer

Overexpression of branched-chain amino acid aminotransferases rescues the growth defects of cells lacking the Barth syndrome-related gene TAZ1

(2019) Diana Antunes et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Role of branched-chain amino acid–catabolizing enzymes in intertissue signaling, metabolic remodeling, and energy homeostasis

(2019) Dipsikha Biswas et al.   FASEB JOURNAL

Metabolic engineering advances and prospects for amino acid production

(2019) Volker F. Wendisch   METABOLIC ENGINEERING

Computational Design of Multisubstrate Enzyme Specificity

(2019) Antony D. St-Jacques et al.   ACS Catalysis

Characterization of a New Saccharomyces cerevisiae Isolated From Hibiscus Flower and Its Mutant With L-Leucine Accumulation for Awamori Brewing

(2019) Takayuki Abe et al.   Frontiers in Genetics

Expanding the genetic and phenotypic spectrum of branched‐chain amino acid transferase 2 deficiency

(2019) Ina Knerr et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Data mining of the expression and regulatory role of BCAT1 in hepatocellular carcinoma

(2019) Haifan Zou et al.   Oncology Letters

Inborn errors of enzymes in glutamate metabolism

(2019) Lynne Rumping et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

(2018) Huajie Li et al.   BIOSCIENCE REPORTS

Circulating tumor cells undergoing EMT provide a metric for diagnosis and prognosis of patients with hepatocellular carcinoma

(2018) Lu-Nan Qi et al.   CANCER RESEARCH

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Overexpression of BCAT1 is a prognostic marker in gastric cancer

(2018) Yuan Xu et al.   HUMAN PATHOLOGY

LncRNA CRNDE promotes hepatocellular carcinoma cell proliferation, invasion, and migration through regulating miR-203/ BCAT1 axis

(2018) Degang Ji et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study

(2018) Kara Wegermann et al.   PLoS One

The overexpression of cucumber (Cucumis sativus L.) genes that encode the branched-chain amino acid transferase modulate flowering time in Arabidopsis thaliana

(2018) Jeong Hwan Lee et al.   PLANT CELL REPORTS

Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the YeastSaccharomyces cerevisiae

(2017) James González et al.   GENETICS

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes

(2017) Adriana Espinosa-Cantú et al.   GENETICS

Uncovering the role of branched-chain amino acid transaminases in Saccharomyces cerevisiae isobutanol biosynthesis

(2017) Sarah K. Hammer et al.   METABOLIC ENGINEERING

MicroRNA-218 inhibits tumor growth and increases chemosensitivity to CDDP treatment by targeting BCAT1 in prostate cancer

(2017) Wenjing Zhu et al.   MOLECULAR CARCINOGENESIS

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

(2017) V Thewes et al.   ONCOGENE

Abscisic acid-regulated protein degradation causes osmotic stress-induced accumulation of branched-chain amino acids in Arabidopsis thaliana

(2017) Tengfang Huang et al.   PLANTA

BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases

(2017) Adonia E. Papathanassiu et al.   Nature Communications

The Impact of Single Amino Acids on Growth and Volatile Aroma Production by Saccharomyces cerevisiae Strains

(2017) Samantha Fairbairn et al.   Frontiers in Microbiology

Diversification of Transcriptional Regulation Determines Subfunctionalization of Paralogous Branched Chain Aminotransferases in the YeastSaccharomyces cerevisiae

(2017) James González et al.   GENETICS

Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes

(2017) Adriana Espinosa-Cantú et al.   GENETICS

BCAT1 is a New MR Imaging-related Biomarker for Prognosis Prediction in IDH1-wildtype Glioblastoma Patients

(2017) Hye Rim Cho et al.   Scientific Reports

Increasing isobutanol yield by double-gene deletion of PDC6 and LPD1 in Saccharomyces cerevisiae

(2016) Aili Zhang et al.   CHINESE JOURNAL OF CHEMICAL ENGINEERING

BCAT1, a key prognostic predictor of hepatocellular carcinoma, promotes cell proliferation and induces chemoresistance to cisplatin

(2016) Yi-Hu Zheng et al.   LIVER INTERNATIONAL

Metabolic engineering of Saccharomyces cerevisiae for the overproduction of short branched-chain fatty acids

(2016) Ai-Qun Yu et al.   METABOLIC ENGINEERING

Altered Expression of Human Mitochondrial Branched Chain Aminotransferase in Dementia with Lewy Bodies and Vascular Dementia

(2016) Emma L. Ashby et al.   NEUROCHEMICAL RESEARCH

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

A global genetic interaction network maps a wiring diagram of cellular function

(2016) M. Costanzo et al.   SCIENCE

Evolution of Mitochondria as Signaling Organelles

(2015) Navdeep S. Chandel   Cell Metabolism

Functional roles of a predicted branched chain aminotransferase encoded by the LkBAT1 gene of the yeast Lachancea kluyveri

(2015) Javier Montalvo-Arredondo et al.   FUNGAL GENETICS AND BIOLOGY

BCAT1 overexpression is an indicator of poor prognosis in patients with urothelial carcinomas of the upper urinary tract and urinary bladder

(2015) I-Wei Chang et al.   HISTOPATHOLOGY

Isolation and characterization of awamori yeast mutants with l -leucine accumulation that overproduce isoamyl alcohol

(2015) Hiroshi Takagi et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Hypervalinemia and hyperleucine-isoleucinemia caused by mutations in the branched-chain-amino-acid aminotransferase gene

(2015) X. L. Wang et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

BCAT1 expression associates with ovarian cancer progression: possible implications in altered disease metabolism

(2015) Zhi-Qiang Wang et al.   Oncotarget

Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae

(2015) Joanne M. Kingsbury et al.   PLoS Genetics

Yeast: the soul of beer’s aroma—a review of flavour-active esters and higher alcohols produced by the brewing yeast

(2014) Eduardo J. Pires et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Metabolic engineering of Saccharomyces cerevisiae for the production of isobutanol and 3-methyl-1-butanol

(2014) Seong-Hee Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Glutamate as a neurotransmitter in the healthy brain

(2014) Y. Zhou et al.   JOURNAL OF NEURAL TRANSMISSION

Metabolic Engineering of Microorganisms for the Production of Higher Alcohols

(2014) Y. J. Choi et al.   mBio

The specificity and kinetic mechanism of branched-chain amino acid aminotransferase fromEscherichia colistudied with a new improved coupled assay procedure and the enzyme's potential for biocatalysis

(2013) Xuejing Yu et al.   FEBS Journal

Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics

(2013) Linn Fagerberg et al.   MOLECULAR & CELLULAR PROTEOMICS

Over-expression of BCAT1, a c-Myc target gene, induces cell proliferation, migration and invasion in nasopharyngeal carcinoma

(2013) Wen Zhou et al.   Molecular Cancer

A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis

(2013) Paola Picotti et al.   NATURE

Compartmentalization of metabolic pathways in yeast mitochondria improves the production of branched-chain alcohols

(2013) José L Avalos et al.   NATURE BIOTECHNOLOGY

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

(2013) Martje Tönjes et al.   NATURE MEDICINE

EngineeringSaccharomyces cerevisiaefermentative pathways for the production of isobutanol

(2013) Ebele Ofuonye et al.   Biofuels-UK

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Crystal Structures of Complexes of the Branched-Chain Aminotransferase from Deinococcus radiodurans with  -Ketoisocaproate and L-Glutamate Suggest the Radiation Resistance of This Enzyme for Catalysis

(2012) C.-D. Chen et al.   JOURNAL OF BACTERIOLOGY

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation

(2012) Jonathon Hull et al.   JOURNAL OF NEUROCHEMISTRY

Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study

(2012) Glyn Howatson et al.   Journal of the International Society of Sports Nutrition

Intake of branched-chain amino acids influences the levels of MAFbx mRNA and MuRF-1 total protein in resting and exercising human muscle

(2011) Marcus Borgenvik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ixr1p and the control of the Saccharomyces cerevisiae hypoxic response

(2011) Ángel Vizoso-Vázquez et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The effect of branched chain amino acids on psychomotor performance during treadmill exercise of changing intensity simulating a soccer game

(2011) Piotr Wiśnik et al.   Applied Physiology Nutrition and Metabolism

Pyridoxal phosphate enzymology

(2011) Michael D. Toney   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Increased isobutanol production in Saccharomyces cerevisiae by overexpression of genes in valine metabolism

(2011) Xiao Chen et al.   Biotechnology for Biofuels

Saccharomyces cerevisiae Bat1 and Bat2 Aminotransferases Have Functionally Diverged from the Ancestral-Like Kluyveromyces lactis Orthologous Enzyme

(2011) Maritrini Colón et al.   PLoS One

Trends and challenges in the microbial production of lignocellulosic bioalcohol fuels

(2010) Christian Weber et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A branched-chain aminotransferase may regulate hormone levels by affecting KNOX genes in plants

(2009) Feng Gao et al.   PLANTA

Gene expression in human NAFLD

(2008) Dario Greco et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Monitoring the influence of high-gravity brewing and fermentation temperature on flavour formation by analysis of gene expression levels in brewing yeast

(2008) S. M. G. Saerens et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Regulatory Control of Human Cytosolic Branched-Chain Aminotransferase by Oxidation and S-Glutathionylation and Its Interactions with Redox Sensitive Neuronal Proteins†

(2008) Myra E. Conway et al.   BIOCHEMISTRY

Linking gene regulation and the exo-metabolome: A comparative transcriptomics approach to identify genes that impact on the production of volatile aroma compounds in yeast

(2008) Debra Rossouw et al.   BMC GENOMICS