Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

Hyperammonemia and proteostasis in cirrhosis

(2018) Srinivasan Dasarathy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Branched-chain amino acid metabolism in cancer

(2018) Elitsa A. Ananieva et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Acute effects of phenylbutyrate on glutamine, branched-chain amino acid and protein metabolism in skeletal muscles of rats

(2017) Milan Holecek et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Branched-chain amino acid supplementation in treatment of liver cirrhosis: Updated views on how to attenuate their harmful effects on cataplerosis and ammonia formation

(2017) Milan Holeček   NUTRITION

Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions

(2017) Milan Holeček   Journal of Cachexia Sarcopenia and Muscle

Novel metabolic and physiological functions of branched chain amino acids: a review

(2017) Shihai Zhang et al.   Journal of Animal Science and Biotechnology

Branched-chain amino acids differently modulate catabolic and anabolic states in mammals: a pharmacological point of view

(2016) Francesco Bifari et al.   BRITISH JOURNAL OF PHARMACOLOGY

Alterations in protein and amino acid metabolism in rats fed a branched-chain amino acid- or leucine-enriched diet during postprandial and postabsorptive states

(2016) Milan Holecek et al.   Nutrition & Metabolism

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: a meta-analysis

(2015) Ling Chen et al.   Nutrition Journal

Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis

(2015) João Pedroso et al.   Nutrients

Glutamine deficiency in extracellular fluid exerts adverse effects on protein and amino acid metabolism in skeletal muscle of healthy, laparotomized, and septic rats

(2014) Milan Holecek et al.   AMINO ACIDS

Management of protein-energy wasting in non-dialysis-dependent chronic kidney disease: reconciling low protein intake with nutritional therapy

(2013) Csaba P Kovesdy et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Human Mild Traumatic Brain Injury Decreases Circulating Branched-Chain Amino Acids and Their Metabolite Levels

(2013) Cameron B. Jeter et al.   JOURNAL OF NEUROTRAUMA

Evidence of a vicious cycle in glutamine synthesis and breakdown in pathogenesis of hepatic encephalopathy–therapeutic perspectives

(2013) Milan Holecek   METABOLIC BRAIN DISEASE

Dietary management of urea cycle disorders: European practice

(2013) S. Adam et al.   MOLECULAR GENETICS AND METABOLISM

Branched-chain amino acid supplementation: impact on signaling and relevance to critical illness

(2013) John S. A. Mattick et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

DNA damage in an animal model of maple syrup urine disease

(2012) Giselli Scaini et al.   MOLECULAR GENETICS AND METABOLISM

Effects of Diets Supplemented with Branched-Chain Amino Acids on the Performance and Fatigue Mechanisms of Rats Submitted to Prolonged Physical Exercise

(2012) Gina Falavigna et al.   Nutrients

The effects of branched-chain amino acid granules on the accumulation of tissue triglycerides and uncoupling proteins in diet-induced obese mice

(2011) Mie Arakawa et al.   ENDOCRINE JOURNAL

Alterations in protein metabolism and amino acid concentrations in rats fed by a high-protein (casein-enriched) diet – Effect of starvation

(2011) Milan Holecek et al.   FOOD AND CHEMICAL TOXICOLOGY

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle

(2010) Milan Holecek et al.   AMINO ACIDS

Phenylbutyrate therapy for maple syrup urine disease

(2010) Nicola Brunetti-Pierri et al.   HUMAN MOLECULAR GENETICS

Three targets of branched-chain amino acid supplementation in the treatment of liver disease

(2010) Milan Holecek   NUTRITION

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

EFFECT OF EXERCISE ON GLUTAMINE SYNTHESIS AND TRANSPORT IN SKELETAL MUSCLE FROM RATS

(2009) Ronaldo VT dos Santos et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Effects of streptozotocin-induced diabetes in domestic pigs with focus on the amino acid metabolism

(2009) M Jensen-Waern et al.   LABORATORY ANIMALS

Dietary branched chain amino acids ameliorate injury-induced cognitive impairment

(2009) J. T. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus

(2008) Teiji Kuzuya et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Can Glutamine Enable the Critically Ill to Cope Better With Infection?

(2008) Gil Hardy et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION