Defect of branched-chain amino acid metabolism promotes the development of Alzheimer’s disease by targeting the mTOR signaling

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Restoration of metabolic health by decreased consumption of branched-chain amino acids

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Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer

(2017) Prasenjit Dey et al.   NATURE

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer

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Branched-chain amino acids and Alzheimer’s disease: a Mendelian randomization analysis

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Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease

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Impaired Amino Acid Transport at the Blood Brain Barrier Is a Cause of Autism Spectrum Disorder

(2016) Dora C. Tărlungeanu et al.   CELL

The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging

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Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

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Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial

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(2016) Rebecca G. Canter et al.   NATURE

Human gut microbes impact host serum metabolome and insulin sensitivity

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A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

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Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells

(2016) Tsung-Ho Ying et al.   Scientific Reports

Amyloid biomarkers in Alzheimer's disease

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Brain metabolic dysfunction at the core of Alzheimer's disease

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Alzheimer’s Disease and Type 2 Diabetes: Multiple Mechanisms Contribute to Interactions

(2014) Anusha Jayaraman et al.   Current Diabetes Reports

Repurposing Diabetes Drugs for Brain Insulin Resistance in Alzheimer Disease

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Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development

(2014) Jared R Mayers et al.   NATURE MEDICINE

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

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Mutations in BCKD-kinase Lead to a Potentially Treatable Form of Autism with Epilepsy

(2012) G. Novarino et al.   SCIENCE

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

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(2011) Thomas J Wang et al.   NATURE MEDICINE

Branched-Chain Amino Acid Supplementation Promotes Survival and Supports Cardiac and Skeletal Muscle Mitochondrial Biogenesis in Middle-Aged Mice

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Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY